Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens

Davies, Gareth; Vincent, John P.; Packer, Martin J.; Murray, David C.

doi:10.1016/j.slasd.2021.11.004

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Addressing the Challenges Of Activator Discovery1

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2023

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Cited by 3 publications

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“…Such uncertain fits could be penalized when ranking compounds on concentration-response curve quality and the generated EC 50 value. To prevent useful compounds from being discarded may require a degree of manual intervention in viewing the curves, assessing the variability of EC 50 values and the position of the estimation of the degree of activation [62] . In contrast, compounds with high affinity (lower values of K x ) and lower values of a would have more complete curves (see Fig.…”

Section: Addressing the Challenges Of Activator Discoverymentioning

confidence: 99%