“…Such uncertain fits could be penalized when ranking compounds on concentration-response curve quality and the generated EC 50 value. To prevent useful compounds from being discarded may require a degree of manual intervention in viewing the curves, assessing the variability of EC 50 values and the position of the estimation of the degree of activation [62] . In contrast, compounds with high affinity (lower values of K x ) and lower values of a would have more complete curves (see Fig.…”
Section: Addressing the Challenges Of Activator Discoverymentioning
“…Such uncertain fits could be penalized when ranking compounds on concentration-response curve quality and the generated EC 50 value. To prevent useful compounds from being discarded may require a degree of manual intervention in viewing the curves, assessing the variability of EC 50 values and the position of the estimation of the degree of activation [62] . In contrast, compounds with high affinity (lower values of K x ) and lower values of a would have more complete curves (see Fig.…”
Section: Addressing the Challenges Of Activator Discoverymentioning
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