A new method of constructing quasitriangular group-cograded multiplier Hopf algebras is provided. For a multiplier Hopf dual pairing σ between regular multiplier Hopf algebras A and B, we introduce the concept of a σ -compatible pairing ( , , σ ), where and are actions of the twisted semi-direct group S (G) of a group G on A and B, respectively. We construct a twisted double group-cograded multiplier Hopf algbera D (A, B; σ, , ). Furthermore, if there is a canonical multiplier in M(B ⊗ A) we show existence of quasitriangular structure on D (A, B; σ, , ). As an application, special cases and examples are given.