Group C Streptococcal Osteomyelitis

Barson, William J.

doi:10.1097/01241398-198605000-00016

Cited by 15 publications

(7 citation statements)

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“…However, more recent studies revealed that S. dysgalactiae subsp. equisimilis overlaps with the infection spectrum of S. pyogenes, including localized infections such as tonsillitis and superficial skin infections (2,12,16,51) and severe invasive infections such as arthritis, osteomy-elitis, pleuropneumonia, peritonitis, intra-abdominal and epidural abscesses, meningitis, endocarditis, puerperal septicemia, neonatal infections, necrotizing fasciitis, myositis, and streptococcal toxic shock syndrome, as well as the nonsuppurative sequelae and rheumatic fever (2,4,9,12,13,26,27,(36)(37)(38)44). A proportional increase in human infections caused by S. dysgalactiae subsp.…”

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Delineation of Streptococcus dysgalactiae, Its Subspecies, and Its Clinical and Phylogenetic Relationship to Streptococcus pyogenes

Jensen

Kilian

2012

J Clin Microbiol

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The taxonomic status and structure of Streptococcus dysgalactiae have been the object of much confusion. Bacteria belonging to this species are usually referred to as Lancefield group C or group G streptococci in clinical settings in spite of the fact that these terms lack precision and prevent recognition of the exact clinical relevance of these bacteria. The purpose of this study was to develop an improved basis for delineation and identification of the individual species of the pyogenic group of streptococci in the clinical microbiology laboratory, with a special focus on S. dysgalactiae. We critically reexamined the genetic relationships of the species S. dysgalactiae, Streptococcus pyogenes, Streptococcus canis, and Streptococcus equi, which may share Lancefield group antigens, by phylogenetic reconstruction based on multilocus sequence analysis (MLSA) and 16S rRNA gene sequences and by emm typing combined with phenotypic characterization. Analysis of concatenated sequences of seven genes previously used for examination of viridans streptococci distinguished robust and coherent clusters. S. dysgalactiae consists of two separate clusters consistent with the two recognized subspecies dysgalactiae and equisimilis. Both taxa share alleles with S. pyogenes in several housekeeping genes, which invalidates identification based on single-locus sequencing. S. dysgalactiae, S. canis, and S. pyogenes constitute a closely related branch within the genus Streptococcus indicative of recent descent from a common ancestor, while S. equi is highly divergent from other species of the pyogenic group streptococci. The results provide an improved basis for identification of clinically important pyogenic group streptococci and explain the overlapping spectrum of infections caused by the species associated with humans.

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confidence: 99%

Delineation of Streptococcus dysgalactiae, Its Subspecies, and Its Clinical and Phylogenetic Relationship to Streptococcus pyogenes

Jensen

Kilian

2012

J Clin Microbiol

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“…11 Although Lemierre Syndrome caused solely by this pathogen has not been reported in the past, there have been reports of endocarditis, pneumonia, arthritis, cellulitis, and osteomyelitis. [11][12][13][14] Because group C streptococcus is highly sensitive to b-lactam antibiotics, this patient was discharged from the hospital on a treatment regimen including IV ceftriaxone. Ceftriaxone was chosen over other penicillin derivatives because of its convenient once-a-day dosing.…”

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confidence: 99%

Lemierre Syndrome Caused by Group C Streptococcus

Blossom¹,

Shah²,

Armitage³

2005

Infectious Diseases in Clinical Practice

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“…These observations, plus the well-documented propensity of group C streptococci to cause bacteremia and life-threatening invasive disease in humans (2,11,13,14,29,35,39,42,43), prompted the present study. Because of the preeminent role of M protein in virulence of group A streptococci, we directed our attention to this molecule.…”

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confidence: 99%

M proteins of group C streptococci isolated from patients with acute pharyngitis

1996

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We studied 15 strains of group C streptococci (Streptococcus equisimilis) isolated from the throats of college students with acute pharyngitis and 5 strains isolated from patients with noninfectious problems. Nineteen of the 20 strains resisted phagocytic killing during incubation in normal human blood, suggesting that they might express M proteins. Genomic DNA from all 20 strains hybridized with a probe corresponding to the carboxyterminal one-third of the group A M-protein gene emm24, a region that is highly conserved among M proteins of group A and group G streptococci. The DNA sequences of the N-terminal (variable) regions of the M-protein-encoding genes from two disease-associated group C isolates and one control isolate were determined. The predicted amino acid sequences of the two pharyngitis strains were identical and were 88% homologous to the amino acid sequence of a group G M-protein gene. The predicted terminal amino acid sequence of the control strain does not correspond to any such sequences in the GenBank database. All three strains studied possess the conserved region domain common to class I group A M-protein types epidemiologically associated with rheumatic fever. These studies demonstrate the presence of M proteins in strains of S. equisimilis isolated in cases of endemically occurring acute pharyngitis. Certain of these proteins are similar to those of group G streptococci, while others may represent new M types. The similarity in structure and function between M proteins of nonrheumatogenic serogroups and those of rheumatogenic group A streptococci suggests that factors other than or in addition to M protein per se are likely involved in the pathogenesis of rheumatic fever.

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Group C Streptococcal Osteomyelitis

Cited by 15 publications

References 0 publications

Delineation of Streptococcus dysgalactiae, Its Subspecies, and Its Clinical and Phylogenetic Relationship to Streptococcus pyogenes

Delineation of Streptococcus dysgalactiae, Its Subspecies, and Its Clinical and Phylogenetic Relationship to Streptococcus pyogenes

Lemierre Syndrome Caused by Group C Streptococcus

M proteins of group C streptococci isolated from patients with acute pharyngitis

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