Group B Streptococcal Neonatal Infection

Brown, George L.; Tull, A. H.

doi:10.1097/00006250-198003001-00043

Cited by 14 publications

(3 citation statements)

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“…Group B P-haemolytic streptococci were the most important aerobic bacteria found in the women with PROM. As group B strcptococci are frequently implicated in maternal and especially severe neonatal infections (Baker & Barret 1973;Bobitt & Ledger 1976;Bobitt 1980) Monif 1974) has been reported previously. This finding is not supported by our isolation of CMV from only one patient with PROM and one control subject.…”

Section: Discussionmentioning

confidence: 82%

“…fragilis is the most frequently isolated anaerobic species in obstetric and gynaecologic infections (Ledger et al 1971 ;Chow et al 1975). The occurrence of B. fragilis in manifest or occult obstetric infections is interesting, since this encountered in healthy pregnant women, the attack rate being rather low (Baker & Barret 1973), Bobitt & Ledger (1976) have suggested that a prerequisite for maternal or neonatal infection with group B streptococci is a heavy cervico-vaginal growth of the microorganism, whch is found in about 25% of the carriers (Bobitt 1980). A possible relation between ascending group B streptococcal infection and PROM has been postulated in previous reports (Bobitt & Ledger 1976;Evaldson et a/.…”

Section: Discussionmentioning

confidence: 99%

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Premature rupture of the membranes and ascending infection

Evaldson

Malmborg²,

Nord³

1982

BJOG

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The association of premature rupture of the membranes (PROM) and ascending infection was investigated in 15 women. Bacteriological, histological and immunofluorescence methods were used to study infection at various levels in the birth canal. In most of the women the membranes as well as the placentae showed heavy bacterial invasion. Bacterial distribution within the membranes showed a choriodecidual preponderance. Ascending infection appears to follow the choriodecidual route and may be a primary pathogenetic event in many instances of PROM. The anaerobe Bacteroides fragilis, which is very infrequently isolated in normal pregnant women, was found in five out of 15 women. Two infants had congenital pneumonia caused by group B streptococci and Huemophilus influenrue respectively. The neonatal outcome with PROM may be influenced by the efficiency of the individual defence mechanisms including the antimicrobial capacity of amniotic fluid.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Premature rupture of the membranes and ascending infection

Evaldson

Malmborg²,

Nord³

1982

BJOG

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“…This may prove to be a limitation of the DLA test since about 40 % of the women who are lightly colonized may escape detection. However, it has been shown that only women who are heavily colonized often deliver heavily GBS-colonized infants subjecting them to a higher risk of developing early-onset GBS disease (Ancona et al , 1980; Bobitt et al , 1980; Boyer et al , 1983; Park et al , 2001). The advantage of antigen detection methods over culture is that non-viable GBS, which may result because of the use of antibiotics or feminine hygiene products, can be detected while the culture remains negative.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of chromogenic medium and direct latex agglutination test for detection of group B streptococcus in vaginal specimens from pregnant women in Lebanon and Kuwait

Ghaddar

Anastasiadis

Jiser

et al. 2014

Journal of Medical Microbiology

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This study was undertaken to evaluate chromogenic medium and a direct latex agglutination test (DLA) for detection of Group B Streptococcus (GBS) in the vaginal specimens of pregnant women, and to ascertain the prevalence of GBS in this population in Kuwait and Lebanon. Vaginal swabs, collected from women at 35-37 weeks of gestation, were cultured on 5 % sheep blood agar (SBA), colistin nalidixic acid agar (CNA), Strept B Select chromogenic agar (SBS) as well as Lim enrichment broth in 168 cases in Lebanon while only SBA was used for 1391 samples in Kuwait. In addition, vaginal samples from 102 GBS-positive and 20 GBS-negative women near the time of delivery were collected in Kuwait for evaluation of the DLA test. During the study period, the prevalence of GBS colonization was determined to be 20.7 % (288/1391) in Kuwait while 18.4 % (31) of 168 pregnant women in Lebanon had vaginal cultures positive for GBS. By direct plating of vaginal swabs on the three media used, the isolation rates of GBS were 51.6, 64.5 and 77.4 % on SBA, CNA and SBS, respectively, which increased to 90.35, 93.1 and 96.8 %, respectively, following subculture in Lim broth after 18 h of incubation. The sensitivity of the DLA test was found to be dependent on the density of GBS colonization, resulting in 100 % sensitivity and 100 % specificity for heavy (.10 2 c.f.u. per swab) and moderately heavy (50-100 c.f.u. per swab) growth of GBS. However, for vaginal specimens yielding ,50 c.f.u. per swab, the sensitivity, specificity, positive and negative predictive values of the DLA test were 100, 55.5, 63.6 and 100 %, respectively. In conclusion, a chromogenic agar, such as SBS, and a DLA test can be used for rapid detection of GBS in pregnant women. The DLA test, in particular, could prove to be a useful tool for immediate detection of GBS in women near delivery so that intrapartum antibiotic prophylaxis can be initiated.

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