Group B Streptococcal Infections in Newborns

Mullaney, Dorothy M.

doi:10.1111/j.1552-6909.2001.tb00012.x

Cited by 18 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nosocomial infections are an important cause of morbidity and mortality in neonates (16,33). Antibiotics are widely used for the treatment of suspected or confirmed neonatal infections due to an immature immune system.…”

mentioning

confidence: 99%

Population Pharmacokinetics of Arbekacin, Vancomycin, and Panipenem in Neonates

Kimura¹,

Sunakawa

Matsuura

et al. 2004

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Population Pharmacokinetics of Arbekacin, Vancomycin, and Panipenem in Neonates

Kimura¹,

Sunakawa

Matsuura

et al. 2004

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…However, GBS is the most common cause of bacterial infections in human newborns, leading to diseases such as pneumonia, sepsis and meningitis [48–50]. GBS is also an emerging pathogen of adult humans; individuals at risk include the elderly, immunocompromised and those with diabetes and malignancies [51–54].…”

Section: Streptococcus Agalactiaementioning

confidence: 99%

Aspects of Eukaryotic-Like Signaling in Gram-Positive Cocci: A Focus on Virulence

Burnside

Rajagopal

2011

Future Microbiol.

View full text Add to dashboard Cite

Living organisms adapt to the dynamic external environment for their survival. Environmental adaptation in prokaryotes is thought to be primarily accomplished by signaling events mediated by two-component systems, consisting of histidine kinases and response regulators. However, eukaryotic-like serine/threonine kinases (STKs) have recently been described to regulate growth, antibiotic resistance and virulence of pathogenic bacteria. This article summarizes the role of STKs and their cognate phosphatases (STPs) in Gram-positive cocci that cause invasive infections in humans. Given that a large number of inhibitors to eukaryotic STKs are approved for use in humans, understanding how serine/threonine phosphorylation regulates virulence and antibiotic resistance will be beneficial for the development of novel therapeutic strategies against bacterial infections.

show abstract

“…LOD (7-89 days of age) is characterized by bloodstream infection with a high incidence of meningeal involvement. The source of causative GBS for LOD is still not completely understood, but community or nosocomial acquisition as well as vertical transmission and prematurity may be implicated (Gagneur et al, 2009;Lin et al, 2003;Mullaney, 2001;Schrag et al, 2000). The vast majority of LOD episodes are caused by a homogeneous capsular type III genetic clone, defined by multilocus sequence typing (MLST) as sequence type (ST) 17 (Gherardi et al, 2007;Jones et al, 2003;Manning et al, 2009;Tazi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of group B streptococcal meningitis in children beyond the neonatal period from Angola

Florindo

Gomes

Rato

et al. 2011

Journal of Medical Microbiology

View full text Add to dashboard Cite

Streptococcus agalactiae is a major pathogen of neonates and immunocompromised adults. Prior studies have demonstrated that, beyond the neonatal period, S. agalactiae rarely causes invasive infections in children. However, during 2004However, during -2005, S. agalactiae was the causative agent of 60 meningitis episodes in children aged 3 months to 12 years from Angola. To identify and study the specific causative genetic lineages of S. agalactiae childhood meningitis, which lack characterization to date, we conducted an extensive molecular analysis of the recovered isolates (n521). This constitutes what we believe to be the first molecular study of the population structure of invasive S. agalactiae isolates from Africa. A low genetic diversity was observed among the isolates, where the majority belonged to clonal complex (CC) 17 presenting the capsular subtype III-2 (86 % of cases) and marked by the intron group II GBSi1, which has previously been observed to be associated with neonatal hosts. The predominance of single-locus variants of sequence type (ST) 17 suggested the local diversification of this hypervirulent clone, which displayed novel alleles of the fbsB and sip virulence genes. The absence of the scpB-lmb region in two S. agalactiae isolates with the Ia/ST23 genotype is more typical of cattle than human isolates. Globally, these data provide novel information about the enhanced invasiveness of the CC17 genetic lineage in older children and suggest the local diversification of this clone, which may be related to the future emergence of a novel epidemic clone in Angola.

show abstract

Group B Streptococcal Infections in Newborns

Cited by 18 publications

References 24 publications

Population Pharmacokinetics of Arbekacin, Vancomycin, and Panipenem in Neonates

Population Pharmacokinetics of Arbekacin, Vancomycin, and Panipenem in Neonates

Aspects of Eukaryotic-Like Signaling in Gram-Positive Cocci: A Focus on Virulence

Molecular epidemiology of group B streptococcal meningitis in children beyond the neonatal period from Angola

Contact Info

Product

Resources

About