Group B streptococcal disease in infants: a case control study

Heath, Paul T; Balfour, Gail; Tighe, Helen; Verlander, Neville Q.; Lamagni, Theresa; Efstratiou, Androulla

doi:10.1136/adc.2008.148874

Cited by 61 publications

(49 citation statements)

References 23 publications

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“…In a case control study that included 138 cases and 305 controls,27 it was indicated that the majority of cases (74%) presented in the first week of life, and 89% of them occurred during the first day of life.…”

Section: Discussionmentioning

confidence: 99%

Maternal and neonatal risk factors for early-onset group B streptococcal disease: a case control study

Al-Kadri

Bamuhair²,

Johani³

et al. 2013

IJWH

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ObjectivesTo identify the prominent maternal and neonatal risk factors associated with early-onset group B streptococcus (EOGBS) disease in neonates and to determine their importance by comparing them with a control group.SettingNeonatal unit at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.PatientsCases were infants <7 days of age with invasive group B streptococcus (GBS) disease diagnosed between January 1, 2000 and December 31, 2009. Controls were healthy infants born in the same hospital during the same period having the same birth weight and gestational age category.Main outcome measuresMaternal risk factors for developing EOGBS disease, feto–maternal and neonatal clinical data, their morbidities, mortalities, and length of hospital stay.ResultsA total of 99 cases and 200 controls were included. The majority of cases presented in the first 72 hours of life (62/99 [63.9%]), of which 87/99 (89.7%) had at least one clinical risk factor for the development of EOGBS disease. Mothers of neonates with EOGBS disease were more likely to have GBS bacteriuria (odds ratio [OR] 10.76, 95% confidence interval [CI] 1.24–93.42), infection in the peripartum period (OR 8.92, CI 2.87–27.68), and temperature ≥38°C (OR 7.10, CI 2.50–20.17). GBS disease was associated with premature rupture of membranes and fetal tachycardia (P<0.01 for both). Neonates with EOGBS disease were more likely to have respiratory distress disease and convulsions, require tube feeding, and have longer hospital stays compared with the controls (P<0.01 for all). Stepwise multiple logistic regression has identified three risk factors that were associated with the highest tendency for the development of EOGBS disease. These were lack of antenatal attendance (OR =0.30 and CI 0.98–0.88), rupture of membranes (OR =9.62 and CI 3.1–29.4), and antibiotic use in labor (OR =0.16 and CI 0.38–0.67).ConclusionA number of maternal risk factors were significantly associated with EOGBS disease. Taking these factors into consideration may result in preventing the occurrence of EOGBS disease, improve maternal and neonatal medical care, decrease their hospital stay, and reduce unnecessary hospital resource utilization.

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Section: Discussionmentioning

confidence: 99%

Maternal and neonatal risk factors for early-onset group B streptococcal disease: a case control study

Al-Kadri

Bamuhair²,

Johani³

et al. 2013

IJWH

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“…Intrapartum fever was the commonest risk factor (31%) for EOD and more frequent than in some other studies (19%) . EOD often starts in utero , which means that IAP is a really pre‐emptive therapy.…”

Section: Discussionmentioning

confidence: 80%

Group B streptococcal disease and genotypes in Australian infants

Zurynski

Gilbert

2015

J Paediatrics Child Health

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“…[32] But such routine neonatal prophylaxis has not gained wide support and its benefi t remain uncertain. In a UK study of invasive GBS disease, [13,36] 89% of early onset cases were identifi ed on day1. Of those developing clinical features on day 1, 97.6% were noted by 12 hours of age.…”

Section: Management Of Newborn Infantmentioning

confidence: 99%

Prevention of perinatal group B streptococcal infections: A review with an Indian perspective

Narava

Rajaram

Ramadevi

et al. 2014

Indian Journal of Medical Microbiology

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Group B Streptococcus (GBS) is an important cause of maternal and neonatal morbidity and mortality in many parts of the world. Asymptomatic colonisation of the vagina and rectum with Group B streptococci is common in pregnancy. Maternal colonisation of GBS can vary depending on ethnicity and geographical distribution. Vertical transmission of this organism from mother to foetus may lead to neonatal GBS disease. Intra-partum use of antibiotics in these women has led to a decrease in the rate of early onset but not late onset GBS disease. Identification of women with GBS is the key factor in the prevention of perinatal GBS disease. There are different screening strategies available to identify women at risk of perinatal GBS disease. Clinicians continue to face the challenge of choosing between preventive strategies to reduce the impact of perinatal GBS disease. Controversy exists regarding the ideal preventive strategy. In India, the mortality and morbidity associated with the GBS disease remains largely a under-recognised problem. This comprehensive review summarises the salient features of GBS disease and discusses the epidemiology, risk factors, screening strategies, intra-partum antibiotic prophylaxis with an Indian perspective and how it compares with the Western nations.

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Group B streptococcal disease in infants: a case control study

Abstract: Independent of birth weight, a number of maternal, birth and neonatal factors are significantly associated with GBS disease. The management of babies with GBS disease results in an appreciable use of hospital resources.

Cited by 61 publications

References 23 publications

Maternal and neonatal risk factors for early-onset group B streptococcal disease: a case control study

Maternal and neonatal risk factors for early-onset group B streptococcal disease: a case control study

Group B streptococcal disease and genotypes in Australian infants

Prevention of perinatal group B streptococcal infections: A review with an Indian perspective

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