Group A Streptococcus Epidemiology and Vaccine Implications

Rapid Emergence of emm84 among Invasive Streptococcus pyogenes Infections in Finland

“…The sudden upsurge of infections caused by emm84 strains presumably reflects the population's lack of immunity against this uncommon strain type. Type M/emm84 is not included in the 26-valent or hexavalent M-protein-based vaccine approaches, which may need to be reevaluated and adapted to future changes in type prevalence to ensure the efficacy of the vaccine (3,10,16,19). Our findings further emphasize the importance of global emm type surveillance and outcome analyses.…”

The antibacterial and antifungal analysis of crude extracts from the leaves and bark of Pimenta species found in Jamaica

“…Streptococcus A (Group A Streptococcus, GAS) was susceptible to the effect of the P. jamaicensis crude extracts, however, the hexane extract was the most active, while the crude ethyl acetate and methanol extracts were partially active against Streptococcus B. Streptococcus A is usually spread via mucus from the nose, throat or via skin, and is often treated with antibiotics. Over 500,000 deaths have been reported per year for GAS related diseases (Cohen-Poradosu and Kasper, 2007). The P. jamaicensis leaf hexane extract could be an effective natural astringent or disinfectant which could aid with growth control of Streptococcus A. Streptococcus B or Streptococcus agalactiae (Group B Streptococcus, GBS) are bacteria also found commonly in the human body that may cause infections, especially with pregnant women and newborns.…”

Clinical implications of antibiotic resistance: risk of systemic infection fromStaphylococcusandStreptococcus

“…Pharyngitis and impetigo are the most common infections attributed to GAS today, but it can also occasionally lead to purulent and nonpurulent skin infections including cellulitis. It accounts for 15% to 30% of childhood cases of acute pharyngitis and 10% of adult cases (23). Therapy for these infections is primarily aimed to prevent both suppurative (tonsillopharyngeal cellulitis or abscess, otitis media, sinusitis, and necrotizing fasciitis) and nonsuppurative sequelae (acute rheumatic fever, poststreptococcal glomerulonephritis, and streptococcal toxic shock syndrome).…”