Group-a Streptococcal Infection in the Newborn

Lehtonen, O.-P.; Ruuskanen, Olli; Kero, Pentti; Hollo, Outi; Erkkola, Risto; Salmi, Tuula

doi:10.1016/s0140-6736(84)91667-2

Cited by 15 publications

(2 citation statements)

References 3 publications

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“…While Keefer et al (2) found GAS bacteraemia cases in all age groups, this disease has been reported in more recent times mainly in elderly patients (many with underlying conditions) and infrequently in younger patients with underlying conditions such as leukemia or intravenous drug abuse (14,15,26,32). The formerly feared neonatal GAS bacteraemia has only been reported a few times in the modern medical literature (33,34). In our material all age groups were represented with no clear differences between sexes (Figure 1), and in contrast to Keefer et al (2), who reported many cases of puerperal infection, we registered only one such case.…”

Section: Discussionmentioning

confidence: 43%

Spectrum of disease in bacteraemic patients during aStreptococcus pyogenes serotype M-1 epidemic in Norway in 1988

Bucher

Martín

et al. 1992

Eur. J. Clin. Microbiol. Infect. Dis.

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All 87 known cases of bacteraemia due to Streptococcus pyogenes (beta-haemolytic group A streptococci) occurring during the peak of a nationwide outbreak in Norway (population 4.2 million) between January and June 1988 were reviewed. Clinical features varied widely and appeared largely to be dependent on the patients' age. The case fatality rate ranged from 11% in the age group under 30 years to 44% in patients over 60 years. Clinical complications such as shock, severe renal or respiratory failure or serious local infection occurred particularly in 30-to 59-year old individuals. Shock was manifest in 32% of the patients and carried a 68% case fatality rate. Chronic heart disease in the elderly and pneumonia seemed to be associated with a fatal outcome. In the 25 patients (29%) who died the disease showed a fulminant course, 80% dying within 48 hours after admission. However, 56% of the patients had experienced symptoms for more than two days before admission, suggesting that early diagnosis and treatment might possibly have prevented the development of a serious disease. This study revealed a wide spectrum of clinical manifestations in bacteraemia cases in a unique epidemiological situation caused largely by a single serotype of Streptococcus pyogenes; 89% of the 27 preserved bacteraemia strains carried the M-1 antigen. The observations call attention to the ability of these organisms to cause fulminant clinical illness, indicating a probable increase in both invasiveness and toxicity of group A streptococci responsible for the epidemic.

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Section: Discussionmentioning

confidence: 43%

Spectrum of disease in bacteraemic patients during aStreptococcus pyogenes serotype M-1 epidemic in Norway in 1988

Bucher

Martín

et al. 1992

Eur. J. Clin. Microbiol. Infect. Dis.

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“…Enterococci, Listeria, Klebsiella and a-haemolytic streptococci each accounted for 2-3% of the cases, the figures being essentially the same as in the previous five-year period. Apart from a small outbreak of group A streptococci in one hospital (13), these bacteria were not encountered. There were two cases of group G streptococci.…”

Section: Resultsmentioning

confidence: 93%

Neonatal Septicaemia in Finland 1981–85

Vesikari

Isolauri

et al. 1989

Acta Paediatrica

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A survey of blood culture-confirmed neonatal septicaemia was carried out in seven delivery hospitals in 1981-85, for a second successive five-year period. The total number of cases was 377, to compare with 410 in the previous five-year period. Group B streptococcus (GBS) was throughout the major pathogen (29%), followed by Staphylococcus aureus (15%) and Escherichia coli (14%), while Staphylococcus epidermidis (10%) has emerged as a significant new causative agent. Septicaemia with very early onset was predominant: 49% of the cases had onset within the first 24 hours; in the majority the symptoms were present from birth. GBS was responsible for 49% of the cases detected in the first 24 hours of life. The overall mortality was 20% as compared to 23% in the previous five-year period, whereas in the very early onset septicaemia mortality was now 18%, down from the preceding 30%. Despite the modest progress, GBS septicaemia with very early onset remains a significant problem, and effective preventive measures are needed.

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Infectious Diseases

Pathology of the Human Placenta

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Group-a Streptococcal Infection in the Newborn

Cited by 15 publications

References 3 publications

Spectrum of disease in bacteraemic patients during aStreptococcus pyogenes serotype M-1 epidemic in Norway in 1988

Spectrum of disease in bacteraemic patients during aStreptococcus pyogenes serotype M-1 epidemic in Norway in 1988

Neonatal Septicaemia in Finland 1981–85

Infectious Diseases

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