Group 4 metallocenes in bioorganometallic chemistry

Erker, Gerhard

doi:10.1016/j.jorganchem.2006.11.023

Cited by 22 publications

(9 citation statements)

References 86 publications

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“…Three excellent reviews that lay the foundations of the subject have already been published, [1][2][3] one written in German. Leading reviews on various aspects of bioorganometallic chemistry, although more specialised in their subject matter, include a general review on organometallic pharmaceuticals, 4 and reviews on the pharmaceutical applications of ferrocenes, 5 group 4 metallocenes, 6 CO releasing compounds 7 and ruthenium-arene anticancer compounds, 8 on organometallics in radiopharmacy, 9 supramolecular organometallics 10 and receptors. 11 Ge´rard Jaouen has also edited the first book on the topic which covers all the diverse and interdisciplinary topics within the field.…”

Section: Introductionmentioning

confidence: 99%

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

2009

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In undergraduate level organometallic chemistry courses students are usually taught that organometallic compounds are toxic and unstable in air and water. While this is true of many complexes, some are also non-toxic and stable in air and water. Indeed, bioorganometallic chemistry, the study of biomolecules or biologically active molecules that contain at least one carbon directly bound to a metal, is a thriving subject, and air and water stability is a general pre-requisite. This interdisciplinary field is located at the borderline between chemistry, biochemistry, biology and medicine. In this tutorial review, various aspects of bioorganometallic chemistry are introduced, with the main emphasis on medicinal organometallic compounds. Organometallic therapeutics for cancer, HIV and malaria and other medicinal applications are described. It is also shown how rational ligand design has led to new improved therapies much in the same way that an organometallic chemist working in catalysis will design new ligands for improved activities.

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Section: Introductionmentioning

confidence: 99%

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

2009

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“…Many of these putative drugs are centered on classical organometallic motifs, e.g. metallocenes [53,54], metalarene complexes [55], metal carbonyl, and carbene complexes [56]. Discovery of the antiproliferative and antitumor activity of cisplatin and its derivatives initiated the investigation for the possible therapeutic applications of other metal-based drugs, often organometallic compounds [57][58][59][60][61][62][63], and more particularly organotin(IV) compounds [64][65][66][67][68][69].…”

Section: Introductionmentioning

confidence: 99%

Self-assembly and antitumor activity of an organotin coordination polymer containing a helical structure based on copper cyanide and phenanthroline ligand

Etaiw

Abdou

Faheim

2015

Journal of Coordination Chemistry

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“…8 Some significant general developments will be described in this review. At the same time this compilation will be used to highlight some recent progress achieved by the M€ unster group in the areas of bio-organometallic chemistry, 9 ansa-metallocenes 8a and frustrated Lewis pair chemistry. 10 Bio-Organometallic Chemistry of Group 4 Metallocenes:…”

Section: Introductionmentioning

confidence: 99%

Bio-Organometallic Chemistry, ansa-Metallocenes, and Frustrated Lewis Pairs: Functional Group Chemistry at the Group 4 Bent Metallocenes

Erker

2011

Organometallics

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Functional group chemistry at the group 4 bent metallocenes is still a challenge, due to the special features of these early-metal systems. Nevertheless, an increasing number of reactions and protocols is being developed for attaching organic functional groups at the bent-metallocene frameworks and for carrying out reactions with them. Here some bio-organometallic bent metallocene systems are discussed. Chemical transformations are presented and discussed, including olefin metathesis and even variants of the Mannich reaction. It is shown that intramolecular [2 þ 2] cycloaddition reactions between alkenyl substituents at the Cp or indenyl rings under dynamic topochemical reaction control can lead to ansa-metallocenes. Frustrated Lewis pair chemistry provides tools, for example, for reduction reactions under very mild conditions.

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Group 4 metallocenes in bioorganometallic chemistry

Cited by 22 publications

References 86 publications

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

Self-assembly and antitumor activity of an organotin coordination polymer containing a helical structure based on copper cyanide and phenanthroline ligand

Bio-Organometallic Chemistry, ansa-Metallocenes, and Frustrated Lewis Pairs: Functional Group Chemistry at the Group 4 Bent Metallocenes

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