Group 1 allergens, transported by mold spores, induce asthma exacerbation in a mouse model

Hernández-Ramírez, Guadalupe; Pazos-Castro, Diego; Torrijos, Elisa Gómez; Yuste-Montalvo, Alma; Romero-Sahagun, Alejandro; González-Klein, Zulema; Jimeno-Nogales, Lucía; Escribese, María M.; Ortega, A.; Nuñez‐Borque, Emilio; Orvay, L Bustamante; Esteban, Vanesa; Brito, Francisco Feo; Barber, Domingo; Tomé-Amat, Jaime; Garrido‐Arandia, María; Díaz‐Perales, Araceli

doi:10.1111/all.14347

Cited by 9 publications

(8 citation statements)

References 8 publications

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“…Alternaria alternata spores from the surface of straw have been shown to carry the same allergens as grass pollen and probably inducing allergen-mediated exacerbations in allergic asthma patients. 28 Besides exposure to allergens, de novo sensitization to Aspergillus fumigatus is also becoming recognized as a risk factor for asthma patients. From baseline to follow-up over a 10-year observation period, asthmatic patients acquired noticeably increased frequencies for specific IgE levels to rAsp f 1.…”

Section: Recent De Velopments In a S Thma-rel Ated G Ene Smentioning

confidence: 99%

“…A wave of exacerbations of allergic asthma can be observed in fall, when grass has undergone senescence and turned to straw, where mold lives. Alternaria alternata spores from the surface of straw have been shown to carry the same allergens as grass pollen and probably inducing allergen‐mediated exacerbations in allergic asthma patients 28 …”

Section: Environmental Risk Factors For the Development Of Asthmamentioning

confidence: 99%

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Advances and recent developments in asthma in 2020

Cevhertas

Öğülür

Maurer

et al. 2020

Allergy

117

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In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis, and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping, and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/ multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers, are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2, and COVID-19.

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Section: Recent De Velopments In a S Thma-rel Ated G Ene Smentioning

confidence: 99%

Section: Environmental Risk Factors For the Development Of Asthmamentioning

confidence: 99%

Advances and recent developments in asthma in 2020

Cevhertas

Öğülür

Maurer

et al. 2020

Allergy

117

View full text Add to dashboard Cite

show abstract

“…Thus, the development of logistic regression models for predicting the daily concentrations of airborne spores could also aid to predict symptoms or improve the diagnosis of fungi-induced airway diseases [ 82 ]. Hernandez-Ramirez et al [ 84 ] described a co-exposure event for grass pollen-allergic patients based on a correlation between high levels of Alternaria spores and asthmatic exacerbations suffered by the patient population when pollen was no longer present. After the identification of Phl p 1-like proteins in grass straw and their ability to bind over the surface of Alternaria spores, the authors suggested that mold spores may act as allergen carriers favoring the development of co-sensitization between Alternaria and other aeroallergens-like group 1 allergens ( Figure 3 a).…”

Section: The Trojan Horse: Alternaria As An Inductor Of Other Allergiesmentioning

confidence: 99%

Alternaria as an Inducer of Allergic Sensitization

Hernández-Ramírez

Barber

Tomé-Amat

et al. 2021

JoF

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Alternaria alternata is a saprophytic mold whose spores are disseminated in warm dry air, the typical weather of the Mediterranean climate region (from 30° to 45°), with a peak during the late summer and early autumn. Alternaria spores are known to be biological contaminants and a potent source of aeroallergens. One consequence of human exposure to Alternaria is an increased risk of developing asthma, with Alt a 1 as its main elicitor and a marker of primary sensitization. Although the action mechanism needs further investigation, a key role of the epithelium in cytokine production, TLR-activated alveolar macrophages and innate lymphoid cells in the adaptive response was demonstrated. Furthermore, sensitization to A. alternata seems to be a trigger for the development of co-sensitization to other allergen sources and may act as an exacerbator of symptoms and an elicitor of food allergies. The prevalence of A. alternata allergy is increasing and has led to expanding research on the role of this fungal species in the induction of IgE-mediated respiratory diseases. Indeed, recent research has allowed new perspectives to be considered in the assessment of exposure and diagnosis of fungi-induced allergies, although more studies are needed for the standardization of immunotherapy formulations.

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“…Food allergens brought in contact by non-oral routes contribute to allergic sensitization. In fact, epidemiological studies in humans indicate that non-oral contact with food allergens is correlated with the risk of a child developing food allergy [ 58 , 59 , 60 ]. In addition, symptomatic food allergy is often observed when a child eats the allergenic food for the first time, which is consistent with a previous sensitization phenomenon by non-oral routes [ 31 ].…”

Section: Oral Mucosa In Food Allergymentioning

confidence: 99%

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

Gómez‐Casado

Sánchez-Solares

Izquierdo

et al. 2021

Foods

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Most prevalent food allergies during early childhood are caused by foods with a high allergenic protein content, such as milk, egg, nuts, or fish. In older subjects, some respiratory allergies progressively lead to food-induced allergic reactions, which can be severe, such as urticaria or asthma. Oral mucosa remodeling has been recently proven to be a feature of severe allergic phenotypes and autoimmune diseases. This remodeling process includes epithelial barrier disruption and the release of inflammatory signals. Although little is known about the immune processes taking place in the oral mucosa, there are a few reports describing the oral mucosa-associated immune system. In this review, we will provide an overview of the recent knowledge about the role of the oral mucosa in food-induced allergic reactions, as well as in severe respiratory allergies or food-induced autoimmune diseases, such as celiac disease.

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Group 1 allergens, transported by mold spores, induce asthma exacerbation in a mouse model

Cited by 9 publications

References 8 publications

Advances and recent developments in asthma in 2020

Advances and recent developments in asthma in 2020

Alternaria as an Inducer of Allergic Sensitization

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

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