Physico-chemical characteristics of 74 boreholes from communities within Densu Basin were assessed following procedures outlined in Standard Methods for the Examination of Water and Wastewater. The aim was to assess the status of the boreholes water quality for any contamination for management action to ensure the quality of health of the people in the area. The water quality parameters analyzed included conductivity, pH, turbidity, color, major ions, nutrients, and metals. The study showed that most of the physico-chemical constituents were within the WHO guideline limits. pH values ranged from 6.0 to 8.21, while conductivity varied between 117 and 3,500 lS/cm and turbidity from 0.6 to 19.0 NTU. However, a few of the parameters fell outside the limits prescribed by the World Health Organization (WHO 2004). Fourteen, 9, and 7% of the boreholes exceeded the WHO guideline values for nitrate (NO 3 ), fluoride (F -) and iron (Fe), respectively. Locations where high concentration of Fe and Mn occurred, efforts must be made to remove them to discourage the use of surface waters which may be contaminated by harmful bacteria.