Ground-glass opacity heralding invasive lung adenocarcinoma with prodromal dermatomyositis: a case report

Beel, Andrew J.; Demos, David S.; Chung, Alfred; Liao, Charles; Lui, Natalie S.

doi:10.1186/s13019-018-0705-x

Cited by 7 publications

(5 citation statements)

References 61 publications

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“…However, in the present case, pulmonary manifestations were observed many years before the incidence of DM symptoms. Nevertheless, in other similar reported cases, pulmonary diseases were diagnosed after the occurrence of DM (3,13).…”

Section: Discussionmentioning

confidence: 85%

Early pulmonary manifestations of dermatomyositis: A case report

Mozdourian

Javidarabshahi

2020

ircmj

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Introduction: Dermatomyositis (DM) is an idiopathic connective tissue disease with a wide range of systemic manifestations. Progressive proximal skeletal muscle weakness and symmetric and inflammatory infiltrates are the main clinical and histological features of DM. Case presentation: In this study, we report the case of a 43-year-old male with DM and early pulmonary manifestations. A 50 mg/g daily dose of prednisolone was administered for the case. The symptoms of muscle weakness improved after 2 weeks. Commonly, pulmonary diseases occur after the occurrence of other connective tissue diseases. However, in the present case, pulmonary manifestations were observed many years before the incidence of DM symptoms. Conclusions: The DM with pulmonary involvement is associated with worse outcomes; accordingly, a higher rate of mortality is reported among these patients. Based on the literature, the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are reliable markers for the diagnosis of DM, along with lung problems.

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Section: Discussionmentioning

confidence: 85%

Early pulmonary manifestations of dermatomyositis: A case report

Mozdourian

Javidarabshahi

2020

ircmj

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“…The association of DM with malignancies has been consistently reported since 1916 with standardized incidence ratios (SIRs) typically ranging from 3 to 6. [ 3 4 ] DM is more commonly reported in older patients with small cell and squamous cell carcinoma of the lung when compared to other malignancies and age group. [ 5 ] The other malignancies commonly found to be associated with DM were colorectal, cervical, ovarian cancer, and non-Hodgkin lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…A histological classification of 48 cases of DM-associated lung malignancies reported in the literature till 2017 found small cell carcinoma in 43.8%, followed by squamous cell carcinoma (16.7%), adenocarcinoma (16.7%), neuroendocrine (6.3%), undifferentiated (4.2%), and others (12.5%). [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Dermatomyositis associated with adenocarcinoma of the lung: A case report

Palakkuzhiyil¹,

Namitha²,

Rakhesh³

et al. 2019

J Family Med Prim Care

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The association of dermatomyositis and underlying malignancies, especially small cell and squamous cell carcinoma of the lung, has been recognized a long time ago. We report the case of a 63-year-old male chronic smoker with adenocarcinoma lung associated with dermatomyositis. The occurrence of dermatomyositis should be considered as a potential presentation of paraneoplastic syndromes and physicians encountering similar clinical situations should perform extensive diagnostic work-up to exclude underlying neoplastic lesions.

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“…Furthermore, the autoimmune articular paracancrotic alterations occur in up to 4% of LC cases [4]. Paraneoplastic syndrome (PNPS) is not immediately associated with a primary neoplasm and its metastases; however, it is generated by the complex inflammatory systemic and local distant alterations, often in the form of the rheumatic and tumor overlap [5,6].The PNPS attending LC manifests itself by rheumatoid-like arthritis (RLA) [7], reducing the survival rate of patients with this malignant tumor [8][9][10], while a successful LC treatment (surgery, radiation chemotherapy) may be followed by the RLA signs' disappearance [11,12]. By contrast to the "primary" rheumatoid arthritis (RA), the RLA mostly affects middle and large joints (for instance, glenohumeral one), has an acute or sub-acute onset and involves a periarticular swelling [13].…”

Section: Introductionmentioning

confidence: 99%

Паранеопластический Ревматоидоподобный Артрит При Раке Легкого

Syniachenko¹,

Iermolaieva²,

Степко³

et al. 2021

PJS

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Background. Paraneoplastic syndrome (PNPS) associated with lung cancer (LC) is characterized by rheumatological, dermatological, endocrinological, neurological, nephrologic and other manifestations. PNPS has become an urgent problem of mo dern oncology, but specifics of its course and immediate tumor process have not been investigated enough. The purpose was to estimate the clinical laboratory manifestations of paraneoplastic (neoplasmic) rheumatoid-like arthritis (RLA) within the context of its associations with LC individual signs. Materials and methods. PNPS was detected in 258 (16%) patients with LC and RLA in 41 (16%) cases of PNPS. These patients (29 men and 15 women with an average age of 57 years) made up the main group of this study, and other 217 patients with PNPS (177 men and 40 women with an average age of 59 years) were included into the comparison group. Ano ther control group was formed by 105 patients (22 men and 83 women aged 46 years) with primary rheumatoid arthritis (RA) without LC. Results. LC with RLA is characterized by the accelerated midlobar localization of tumor process (7.4 times more often), its small-cell variant (5.3 times more often) with a low degree of diffe rentiation, the presence of exudative pleurisy, neoplasms germinating into esophagus and metastases growing into the skeleton (pubic, iliac, femoral and sacral bone, jaw and spine). By contrast to the RA, RLA is characterized by oligoarthritis, enthesopathies, seronegativity by the rheumatoid factor and antibodies to cyclic citrulline peptide, less manifested activity and stages of the articular syndrome (by 1/4), higher damage rate of radiocarpal joints (1.8 times), shoulder joints (4.8 times), metacarpal (2.4 times) and metatarsophalangeal (2.5 times) joints, absence of osteousuras, intra-articular chondromic bodies, Steidi and Goff bo dies. Conclusions. Formation of paraneoplastic RLA is observed in every sixth patient with PNPS caused by LC, which is accompanied by specific features not only of tumor process, but also by joint syndrome in comparison with the primary RA. The obtained data necessitate the further investigation in order to develop criteria for early diagnosis of RLA and informative prognostic factors for the further course of LC.

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Ground-glass opacity heralding invasive lung adenocarcinoma with prodromal dermatomyositis: a case report

Cited by 7 publications

References 61 publications

Early pulmonary manifestations of dermatomyositis: A case report

Early pulmonary manifestations of dermatomyositis: A case report

Dermatomyositis associated with adenocarcinoma of the lung: A case report

Паранеопластический Ревматоидоподобный Артрит При Раке Легкого

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