Ground-glass Cells in Hepatocellular Carcinoma

Stromeyer, F. Wayne; Kamal, G Ishak; Gerber, Michael A.; Mathew, T.

doi:10.1093/ajcp/74.3.254

Cited by 59 publications

(11 citation statements)

References 2 publications

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“…Fine eosinophilic globules were identified in the cytoplasm of hepatocytes in low numbers of WD‐HCC in our study. Cytoplasmic inclusions described in human HCC include Mallory Bodies, accumulation of α1‐antitrypsin, fibrinogen, or hyaline bodies . These inclusions are unrelated to hepatocellular dysfunction, but rather seem to be a manifestation of metabolic errors in neoplastic cells…”

Section: Discussionmentioning

confidence: 99%

Retrospective study of cytologic features of well‐differentiated hepatocellular carcinoma in dogs

Masserdotti¹,

Drigo

2012

Veterinary Clinical Pathol

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Section: Discussionmentioning

confidence: 99%

Retrospective study of cytologic features of well‐differentiated hepatocellular carcinoma in dogs

Masserdotti¹,

Drigo

2012

Veterinary Clinical Pathol

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“…In approximately 1/2 of cases, the tumor cells can have round amphophilic cytoplasmic inclusions, termed “pale bodies” [2] (Figure 1(d)). The exact composition of pale bodies is unclear, but they are immunoreactive for fibrinogen [10, 65, 73, 74], as well as other acute phase proteins [10] suggesting they contain a mixture of proteins that may reflect a fundamental defect in protein folding or secretion. Hyaline bodies (cytoplasmic inclusions that are eosinophilic and tend to be smaller than pale bodies) are also present in nearly half of FLC cases [2].…”

Section: Tumor Findingsmentioning

confidence: 99%

“…Cholestasis is often present in FLC [10], with canalicular bile plugging the most common cholestatic pattern. Because of the frequent cholestasis, FLC commonly has copper deposition [2, 10, 69, 73, 75, 76]. Of note, copper accumulation is also common in ordinary HCC that is cholestatic and is not a defining feature of FLC [77].…”

Section: Tumor Findingsmentioning

confidence: 99%

Fibrolamellar Carcinoma: 2012 Update

Torbenson

2012

Scientifica

146

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Fibrolamellar carcinomas are a unique type of primary liver cancer. They occur most commonly in children and young adults. Their etiology remains a mystery, as they are not associated with chronic liver disease. Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. The most important prognostic feature is whether the tumor is resectable. Histologically, the tumor is made up of large cells that contain abundant mitochondria. The nuclei of the tumor cells have prominent nucleoli. The tumor cells induce the formation of extensive intratumoral fibrosis, which often grows in parallel, or lamellar bands. The tumor cells clearly show hepatocellular features but are also unique in showing both biliary and neuroendocrine differentiation. The uniqueness of fibrolamellar carcinoma extends to their molecular findings. While the genetic abnormalities that lead to fibrolamellar carcinomas are not yet known, studies have shown that they lack mutations in the genes most commonly mutated in typical hepatocellular carcinoma (TP53 and CTNNB1). In this paper, the clinical, pathological, and basic science literature on fibrolamellar carcinoma is comprehensively reviewed. Key areas of needed research are also discussed.

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“…[2][3][4] Pediatric patients with inoperable HCC remain largely unresponsive to chemotherapy, and these children have a very poor prognosis. 5,6 The fibrolamellar (FL) variant of HCC (FL-HCC) was described originally in 1956 by Edmonson as a distinct pathologic variant 7 that also has been referred to as eosinophilic HCC with lamellar fibrosis, 8 polygonal cell with fibrous stroma, 9 HCC with increased stromal fibrosis, 10 eosinophilic glassy cell hepatoma, 8 and fibrolamellar oncocytic hepatoma. 8 In 1980, two simultaneous reports described the clinical entity of FL-HCC in association with patients who had a higher resection rate and better survival compared with patients who had the typical pathologic variant of HCC.…”

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confidence: 99%

Fibrolamellar hepatocellular carcinoma in children and adolescents

Katzenstein¹,

Krailo²,

Malogolowkin³

et al. 2003

Cancer

195

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BACKGROUND Children with hepatocellular carcinoma (HCC) were treated on a prospective, randomized trial and were then analyzed to determine whether children with the fibrolamellar (FL) histologic variant of HCC have a more favorable presentation, increased surgical resectability, greater response to therapy, and improved outcome compared with children who have typical HCC. METHODS Forty‐six patients were enrolled on Pediatric Intergroup Hepatoma Protocol INT‐0098 (Pediatric Oncology Group Study 8945/Children's Cancer Group Study 8881) between August 1989 and December 1992. After undergoing initial surgery or biopsy, children with Stage I HCC (n = 8 patients), Stage III HCC (n = 25 patients), and Stage IV HCC (n = 13 patients) were assigned randomly, regardless of histology, to receive treatment either with cisplatin, vincristine, and fluorouracil (n = 20 patients) or with cisplatin and continuous‐infusion doxorubicin (n = 26 patients). RESULTS Ten of 46 patients (22%) had the fibrolamellar variant of HCC (FL‐HCC). For the entire cohort, the estimated 5‐year event free survival (EFS) rate (± standard deviation) was 17% ± 6%. There was no difference in outcome among patients who were treated with either regimen. The 5‐year EFS rate for patients with FL‐HCC was no different the rate for patients with typical HCC (30% ± 15% vs. 14% ± 6%, respectively; P = 0.18), although the median survival was longer in patients with FL‐HCC. There was no difference in the number of patients with advanced‐stage disease, the incidence of surgical resectability at diagnosis, or the response to treatment between patients with FL‐HCC and patients with typical HCC. CONCLUSIONS Children with FL‐HCC do not have a favorable prognosis and do not respond any differently to current therapeutic regimens than patients with typical HCC. Children with initially resectable HCC have a good prognosis irrespective of histologic subtype, whereas outcomes are poor uniformly for children with advanced‐stage disease. The use of novel chemotherapeutic agents and the incorporation of other treatment modalities are indicated to improve the dismal survival of pediatric patients with all histologic variants of advanced‐stage HCC. Cancer 2003;97:2006–12. © 2003 American Cancer Society. DOI 10.1002/cncr.11292

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Ground-glass Cells in Hepatocellular Carcinoma

Cited by 59 publications

References 2 publications

Retrospective study of cytologic features of well‐differentiated hepatocellular carcinoma in dogs

Retrospective study of cytologic features of well‐differentiated hepatocellular carcinoma in dogs

Fibrolamellar Carcinoma: 2012 Update

Fibrolamellar hepatocellular carcinoma in children and adolescents

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