Gross histopathological effects of an extract of Agave attenuata on the epithelium of the digestive tract of Bulinus africanus

Brackenbury, Therese D.

doi:10.1080/00034989958267

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…The continuous crawling out from the test extract solution of snails exposed to sub lethal concentration is taken as an irritative and avoidance behavior as described by Evans et al [ 34 ] and Brackenbury [ 35 ] for bulinid snails. The ability of the snails to crawl out of the test extract solution and then aggregate at the water-air interface in snails exposed to sub-lethal concentration, where their body is not in close and continuous contact to the plant extract, is similar to observation described by Adetunji and Salawu [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits

et al. 2014

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BackgroundThe negative impact of synthetic molluscicides on the environment and their high cost necessitated search for an alternative approach of using plant extracts for the control of schistosomiasis. The objective of this study was, therefore, to evaluate aqueous and ethyl acetate crude extracts of Glinus lotoides fruits for their cercariacidal activity and molluscicidal effect against schistosome snail intermediate hosts.MethodsAssessment of the molluscicidal activity against Biomphalaria pfeifferi was made by immersion method in accordance with WHO guideline. The results of mortality were statistically analyzed using probit analysis. The attenuating effect of the plant on Schistosoma mansoni cercariae was determined using establishment of adult worms as a parasitological parameter post exposure.ResultsThe 24 and 48 hour-LC50 values for the aqueous extract of G. lotoides fruits were 47.1 and 44.1 mg/L, respectively, whereas that of ethyl acetate were 66.1 and 59.6 mg/L, respectively. The 24 and 48 hour LC90 values for the aqueous extract of G. lotoides fruits were 56.96 and 51.0 mg/L, respectively, while that of ethyl acetate were 77.2 and 70.0 mg/L, respectively. The in vitro cercariacidal activity was determined after 2 hrs of exposure to the aqueous plant extract. It was found out that the LC50 and LC90 values were 18.7 and 41.7 mg/L, respectively. Besides, infectivity of Schistosoma mansoni cercariae to mice was determined by exposing mice to cercariae pre-treated with the sub-lethal concentrations (3.7, 11.6 and 18.7 mg/L) of the aqueous extract. A significant reduction in worm burden in mice was obtained at 11.6 mg/L (p < 0.05). Moreover, the reduction in number of worms recovered was highly significant at 18.7 mg/L (p < 0.001).ConclusionsThe results showed that G. lotoides has molluscicidal activity against B. pfeifferi snails and cercariacidal activity against S. mansoni. Yet, further comprehensive evaluation is recommended for the possible use of G. lotoides against B. pfeifferi and the schistosome parasite.

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Section: Discussionmentioning

confidence: 99%

Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits

et al. 2014

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“…Previous literature reports showed the presence in the plant of steroidal saponins [13–15]. The plant may provide a substitute for niclosamide and be used safely for snail control by rural communities [16] and has been proposed as a contact poison for Bulinus africanus [17]. …”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Biological Studies of Agave attenuata

Zubaır

Rasool

Riaz

et al. 2012

IJMS

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The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10.541–39.35 GAE, mg/100 g) and total flavonoid contents (43.35–304.8 CE, mg/100 g). The extract and some of its fractions showed moderate antimicrobial effects. Leaves extract and fractions also exhibited a good antioxidant potential when measured by DPPH radical scavenging activity and inhibition of lipid peroxidation assays. The hemolytic effect of the plant was found to be in a range of 1.01%–2.64%. From the present study it is concluded that this plant could be used as a source of natural antioxidants and functional food nutraceutical applications.

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Laboratory assessment of molluscicidal activity of crude aqueous and ethanolic extracts of Dalbergia sissoo plant parts against Biomphalaria pfeifferi

Adenusi

Odaibo

2008

Travel Medicine and Infectious Disease

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Gross histopathological effects of an extract of Agave attenuata on the epithelium of the digestive tract of Bulinus africanus

Cited by 5 publications

References 11 publications

Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits

Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits

Phytochemical and Biological Studies of Agave attenuata

Laboratory assessment of molluscicidal activity of crude aqueous and ethanolic extracts of Dalbergia sissoo plant parts against Biomphalaria pfeifferi

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