Gross Ascttes Complicating Hydatidiform Mole

Hooper, Allyssa; Mascarenhas, Anita M.; O'Sullivan, J. V.

doi:10.1111/j.1471-0528.1966.tb06099.x

Cited by 11 publications

(6 citation statements)

References 4 publications

(1 reference statement)

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“…we also checked the articles listed in their references. This search yielded seven english articles describing a total of seven patients with OHSS accompanying molar pregnancy [4][5][6][7][8][9][10]. Table 1 summarizes the patients including the present case.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…OHSS has been reported to be associated with multifetal pregnancy and pregnancy complicated with hypothyroidism, with the former exhibiting high levels of hCG, and the latter having high levels of thyroid stimulating hormone acting similarly to hCG [3]. Molar pregnancy is another example [4][5][6][7][8][9][10]. we present a patient with molar pregnancy in whom OHSS occurred, and it worsened after pregnancy termination.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Ovary hyperstimulation syndrome accompanying molar pregnancy: case report and review of the literature

Suzuki

Matsubara

Uchida

et al. 2014

Arch Gynecol Obstet

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Section: Methods and Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Ovary hyperstimulation syndrome accompanying molar pregnancy: case report and review of the literature

Suzuki

Matsubara

Uchida

et al. 2014

Arch Gynecol Obstet

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“…The pregnancy pathology with the highest HCG values is the mole pregnancy; however, even within this entity the prevalence of OHSS is low. Three cases have been published to our knowledge (Hooper et al, 1966;Moneta et al, 1974;Cappa et al, 1976). The clinical pictures were associated with ascites, and at least one of these cases showed a severe complication by disseminated intravascular coagulation and renal failure (Cappa et al, 1976).…”

Section: Discussionmentioning

confidence: 95%

Ovarian hyperstimulation syndrome (OHSS) in a spontaneous pregnancy with fetal and placental triploidy: information about the general pathophysiology of OHSS

Ludwig¹,

Gembruch²,

Bauer³

et al. 1998

Human Reproduction

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An ovarian hyperstimulation syndrome (OHSS) in spontaneous pregnancies is a very rare event. Hence, clinicians might make wrong decisions, such as laparotomy, because of suspicion of an ovarian carcinoma, or severe complications such as renal insufficiency may develop because the diagnosis and treatment of OHSS are delayed. Here we report a case of a woman in the 15th week of gestation, presenting with a partial hydatidiform mole and a triploidy of fetus and placenta, with an ongoing and severe OHSS even after legal induced abortion. A low vascular endothelium growth factor (VEGF) concentration (50 ng/ml) was measured when human chorionic gonadotrophin (HCG) exceeded 1000 IU/l and was followed by VEGF concentrations >900 ng/ml, when the OHSS developed. The literature on spontaneous pregnancies associated with OHSS is reviewed, and possible reasons for the clinical course presented in this study and the reviewed reports are discussed. The findings in this case contribute to our theory that VEGF is a causative factor of OHSS, but has no impact on the course of this disease.

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“…It may be caused by elevated circulating levels of hCG or TSH mimicking FSH action on granulosa cells; in fact, it been reported in case of hydatiform mole [3][4][5], multiple pregnancy [2], hypothyroidism [6][7][8][9][10][11][12][13][14] or TSH-secreting pituitary adenoma [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…The syndrome is characterized by bilateral, multiple ovarian cysts, ascites, abdominal distension and discomfort, hypoproteinemia, oliguria and electrolyte imbalance. It may be associated to elevated endogenous levels of hCG, as in case of multiple pregnancy [2] or hydatiform mole [3][4][5], or to elevated circulating TSH, as in case of hypothyroidism [6][7][8][9][10][11][12][13][14] or TSH-producing pituitary adenomas [15,16]. hCG or TSH, in fact, maybe responsible for a cross-activation of the FSH receptor (FSHR) on granulosa cells, and may finally cause the cystic evolution of ovarian follicles and the appearance of multiple ovarian cysts.…”

Section: Introductionmentioning

confidence: 99%

Ovarian hyper-stimulation syndrome after spontaneous conception

Lussiana

Guani

Restagno

et al. 2009

Gynecological Endocrinology

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Ovarian hyperstimulation syndrome (OHSS) is rather frequent (1-5%) in women submitted to superovulation with gonadotropins for in vitro fertilisation (IVF), whereas it is very rare in case of spontaneous ovulation. Spontaneous OHSS (sOHSS) was previously described to be associated to hydatiform mole, multiple conception, hypothyroidism in pregnancy. It may also depend on activating mutations of the FSH receptor (FSHR) gene that cause ovarian hyper-responsiveness to circulating FSH or even cross-responsiveness of FSHR to hormones having a structure similar to FSH, such as hCG or TSH. We report, herein, a case of sOHSS in a woman who conceived spontaneously. We checked the presence of all possible factors that could explain the onset of the syndrome, and we evidenced hypothyroidism and abnormally elevated hCG levels in the second trimester of pregnancy. The thorough molecular biology study of FSHR gene did not detect exonic mutations, but revealed the presence of intronic mutations whose role in the onset of sOHSS is still uncertain.

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Gross Ascttes Complicating Hydatidiform Mole

Cited by 11 publications

References 4 publications

Ovary hyperstimulation syndrome accompanying molar pregnancy: case report and review of the literature

Ovary hyperstimulation syndrome accompanying molar pregnancy: case report and review of the literature

Ovarian hyperstimulation syndrome (OHSS) in a spontaneous pregnancy with fetal and placental triploidy: information about the general pathophysiology of OHSS

Ovarian hyper-stimulation syndrome after spontaneous conception

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