Gross and Microscopic Lesions of the Ovaries of Camels from Abattoirs in Eastern Province of Kingdom of Saudi Arabia

Al-Afaleq, A. I.; Homeida, Abdel Gadir M.; Barakat, S.E.M.; Moqbel, M.S.

doi:10.4236/ojpathology.2022.121001

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sex cord-stromal tumors in dromedary camels are extremely rare. Only one case of granulosa cell tumor in a 14-yearold female dromedary camel has been documented (Ali et al, 2013), but not reported, in a subsequently published retrospective research on 210 adult she-camels with ovarian lesions in the Kingdom of Saudi Arabia (Al-Afaleq et al, 2021). However, the prevalence of ovarian tumors in dromedary camels in Egypt was revealed to be 6.8% (34/500); of the recorded cases, sex cord-stromal tumors were found in 14 camels (Elshazly et al, 2019).…”

Section: Introductionmentioning

confidence: 96%

An Update in Histopathology and Immunohistochemistry of Ovarian Sex Cord-Stromal Camel Tumors

Elmaghraby¹,

El-Mashad²,

Moustafa³

et al. 2023

AAVS

View full text Add to dashboard Cite

Background: Sex cord-stromal tumors of the ovary are a rare and heterogeneous group of benign and malignant neoplasms with a wide range of histological characteristics. The current study investigated ovarian sex cord-stromal tumors in dromedary camels slaughtered at Egyptian slaughterhouses between January 2019 and February 2022. The study included 180 female single-humped camels in which all data on the animal's age, location, and gross tumor lesions were documented, and positive ovaries were collected for further histological and immunohistochemical examination.Results: Interestingly, our results diagnosed 15 cases of sex cord-stromal tumors (8.30 %) in the ovary of dromedary camels included; adult granulosa cell tumor (0.55 %), interstitial cell tumor (0.55 %), thecoma or fibrothecoma (1.10 %), steroid cell tumor-NOS (0.55 %), and granulosa-theca cell tumor (5.55 %). Specifically, all cases had distinctive histomorphological appearance characteristics for benign tumors, except adult granulosa cell tumor, which had sarcomatous changes and other features reliable for malignancy. Importantly, granulosa-theca cell tumor exhibited a wide spectrum of histologic patterns as micro/macrofollicular, trabecular, diffuse sheets and Call-Exner bodies; or uncommon patterns as solid follicular, luteinized, insular, tubule-like, and Sertoli-like. Immunohistochemically, the results indicated that vimentin was markedly expressed in the majority of sex cord-stromal tumors (SCSTs), and melan A was typically positive in the steroid-secreting tumors; while inhibin was less sensitive than vimentin for recognizing SCSTs. Conclusions: Diagnosis of sex cord-stromal tumors in camels often present a challenge familiarity with characteristics of the different histopathologic pattern where, in the current study, the granulosa-theca cell tumor was the most frequently diagnosed tumor. Additionally, the use of vimentin and melan A are reliable markers in the differential diagnosis of sex cord-stromal tumors in the ovary of dromedary camels.

show abstract

Section: Introductionmentioning

confidence: 96%