“…This peculiarity raises the question as to whether bone ongrowth might be accelerated if the roughness, i.e., the peak-to-valley contrast, was to be increased on the surface of the grit blast implant itself rather than by coating. Much understanding has been gained from a wide range of experimental work addressing the surface geomorphology of implants tested in the femur, tibia, ulna, and mandible of animals [3, 6-17, 19, 21, 23-25, 27-30, 33, 34] as well as from orthopedic and oral surgery in human clinical studies [1,4,5,18,20,26], and from bioengineering studies in vitro [32] and biological examination of cell attraction to roughened surfaces in vitro [2]. Despite an ongoing proliferation of reports, however, controversy remains on how to design the implant surface most conducive to osseointegration and apposition of remodeled bone matrix to the implant.…”