Griseofulvin‐Induced Red and Hot Ears

Abstract

Dear Editor,Griseofulvin is a natural product, first isolated in 1939 from Penicillium griseofulvum and was first commercially introduced in 1959. It is a polyketide that is derived from acetyl and malonyl coenzyme A precursor molecules to form dehydrogriseofulvin. 1 It inhibits microtubule assembly, affects the formation of the mitotic spindle, and finally inhibits mitosis in dermatophytes. 2 Griseofulvin is mainly used for dermatophytes; however, other uses include anti-inflammatory, cardiovascular, antitumor, and antiviral activity. 3 It has mainly gastrointestinal side effects, but other adverse effects can also be noticed, such as photosensitivity, urticaria, and petechia. 4