Grisan derivatives in pure and mixed monomolecular films

Monomolecular films of compounds with potential dermophilic and prophylactic properties. Esters of dihydroxyacetone

“…Specific details of the film balance, ancillary equipment, and general methods employed in our monolayer studies have already been described (2,(4)(5)(6).…”

“…During the past few years, we have been concerned with the development of agents exerting perdurable insect-repellent and other types of prophylactic activity subsequent to topical or systemic administration (1)(2)(3)(4)(5)(6). Currently, our efforts are focused on compounds designed to provide long-lasting prophylactic efficacy by rneails of the gradual release of an active component from a precursor-type molecule anchored to the epidermal surface (3).…”

Antidermatophytic Properties of Griseofulvin Derivatives with Potential Systemic Insect-Repellent Activity

“…The synthesis and physicochemical evaluation of a number of grisan and coumaranone derivatives designed as potential systemic insect repellents have been reported (1)(2)(3). In this communication, the in uitro antidermatophytic properties of these compounds were evaluated with the expectation that the data could I (grineofulvin) I 0 provide a basis for their quantitative determination in dermal tissue.…”

Synthesis of phenolic esters with potential long-lasting insect-repellent properties

“…Since our efforts are directed toward the development of prophylactic agents effective against pathogenic (or physical) impairments inflicted through the skin, the effect of some of these compounds upon monomolecular films of representative dermal constituents has also been evaluated (2)(3)(4).…”

“…In the course of the synthetic work two compounds (10 and 11) were obtained which, not being esters, cannot release undecanoic acid. They constitute excellent control entities (pseudo precursor-type molecules), however, for our evaluation of relative intrinsic repellencies and of relative dermophilic characteristics; in fact, they are better suited for the task than the ones originally designed for this purpose (1,3,4, and 5).…”