Grip training improves handgrip strength, cognition, and brain white matter in minor acute ischemic stroke patients

Shang, Xin-yuan; Meng, Xian‐Yue; Xiao, Xinxing; Xie, Zongwu; Yuan, Xin

doi:10.1016/j.clineuro.2021.106886

Cited by 13 publications

(22 citation statements)

References 40 publications

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“…A detailed description of key characteristics for the 11 studies [7,8,12,[20][21][22][23][24][25][26][27] incorporated is given in Table 1. There were 824 subjects, 405 in the experimental group and 419 in the control group.…”

Section: Study Characteristics and Quality Assessmentmentioning

confidence: 99%

Aerobic exercises and cognitive function in post-stroke patients: A systematic review with meta-analysis

et al. 2022

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Objective: To study the effect of aerobic exercise on cognitive function of post-stroke patients, especially to identify specific interventions that the most likely to maximize cognitive benefits of stroke patients. Methods: According to the PRISMA principle, the databases of Web of Science, EMBASE, PubMed and Cochrane library were searched to collect randomized controlled trial data of aerobic exercise on cognitive function intervention of post-stroke patients. The Cochrane bias risk evaluation instrument was used to assess the methodological quality of included studies. Review Manager 5.4.1 software was used to analyze heterogeneity and potential publication bias. Results: A total of 11 criteria studies that satisfied the association between aerobic exercise and cognitive function following stroke were selected to be included in the review. Global cognition ability was significantly improved after aerobic exercise intervention (0.51; 95% confidence interval [CI] 0.16–0.86; P = .004), moderate intensity had the largest effect size on improving global cognition ability (0.98; 95% CI 0.48–1.47; P = .0001), none of cognitive flexibility, working memory, selective attention and conflict resolution showed the significant difference from zero. Conclusion: Aerobic exercise has a good impact on enhancing the cognitive dysfunction of patients after stroke, which stroke patients were found to benefit the most from moderate-intensity exercise. However, our studies did not found that aerobic exercise had an active result on cognitive flexibility, working memory, selective attention and contention resolution.

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Section: Study Characteristics and Quality Assessmentmentioning

confidence: 99%

Aerobic exercises and cognitive function in post-stroke patients: A systematic review with meta-analysis

et al. 2022

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“…Higher levels of these peptides have been correlated with greater physical fitness and increased GMV [58], and more importantly, studies showed that resistance activities could stimulate the release of BDNF and evoke neuroplastic changes in frontal and hippocampal regions, which may further translate into cognitive improvements [63][64][65]. Therefore, cytokine-induced alterations in GMV may represent a mechanism through which muscular fitness influences cognition and mental status, yet further research is needed [66].…”

Section: Discussionmentioning

confidence: 99%

Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank

Jiang

Westwater

Noble

et al. 2022

BMC Med

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Background Grip strength is a widely used and well-validated measure of overall health that is increasingly understood to index risk for psychiatric illness and neurodegeneration in older adults. However, existing work has not examined how grip strength relates to a comprehensive set of mental health outcomes, which can detect early signs of cognitive decline. Furthermore, whether brain structure mediates associations between grip strength and cognition remains unknown. Methods Based on cross-sectional and longitudinal data from over 40,000 participants in the UK Biobank, this study investigated the behavioral and neural correlates of handgrip strength using a linear mixed effect model and mediation analysis. Results In cross-sectional analysis, we found that greater grip strength was associated with better cognitive functioning, higher life satisfaction, greater subjective well-being, and reduced depression and anxiety symptoms while controlling for numerous demographic, anthropometric, and socioeconomic confounders. Further, grip strength of females showed stronger associations with most behavioral outcomes than males. In longitudinal analysis, baseline grip strength was related to cognitive performance at ~9 years follow-up, while the reverse effect was much weaker. Further, baseline neuroticism, health, and financial satisfaction were longitudinally associated with subsequent grip strength. The results revealed widespread associations between stronger grip strength and increased grey matter volume, especially in subcortical regions and temporal cortices. Moreover, grey matter volume of these regions also correlated with better mental health and considerably mediated their relationship with grip strength. Conclusions Overall, using the largest population-scale neuroimaging dataset currently available, our findings provide the most well-powered characterization of interplay between grip strength, mental health, and brain structure, which may facilitate the discovery of possible interventions to mitigate cognitive decline during aging.

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“…The isolated aerobic training programs involved: aerobic training [31,42,48,49], high-intensity training [37,39,53,57], and yoga training [43,67]. On the other hand, the control groups participated in programs involving singletask gait training with a treadmill [45,62], performing conventional exercises [29,31,38,39,42,43,46,48,49,55,63,64,67], daily routines [30,41,61,65], which included mobilization of upper and lower limbs, stretching and muscle strengthening with elastic bands and walking [51,52]. An overview of the study and participant characteristics is listed in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Regarding the use of neuropsychological instruments at baseline, of the 23 studies that used a combined rehabilitation training program, only 13 assessed cognitive function as shown in online supplementary material 3, with cases using a single test [29,41,50,61,63,65], two tests [38,44,46,51,59,64], and three tests [52]. In the 11 studies using an isolated rehabilitation training program, 10 assessed cognitive function, either using a single test [37,48,53,57,67], two tests [39,49,55], three tests [31], or four tests [42].…”

Section: Cognitive Function Outcome Measuresmentioning

confidence: 99%

Duration and Efficiency of Combined versus Isolated Aerobic Training Interventions in Post-Stroke Cognition: A Systematic Review

Maeneja,

Ferreira,

Abreu

2024

Port J Public Health

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Background: This study aimed to evaluate the effects of physical activity on the cognition of patients with stroke, comparing the effectiveness of using isolated or combined rehabilitation, as well as the duration and intensity of training, to identify the characteristics of optimal training programs for post-stroke cognitive rehabilitation. Methods: For this systematic review, we followed PRISMA guidelines and searched Web of Science, Scopus, PEDRo, SPORTdiscus, PubMed, Trial Registries, and Google Scholar for studies published between 2013 and April 12, 2023. We included randomized controlled trials (RCTs) of interventions that measured the effect of physical activity on cognition in patients with stroke. We restricted our search to reports published in the English language. Evidence from the RCTs was synthesized. The risk of bias was assessed using the Cochrane risk of bias tool. Results: Of the 1,755 records identified, 34 were eligible, and data were available, with mainly low to moderate risk of general bias. The combined rehabilitation training programs proved more efficient when compared with isolated rehabilitation training programs in several cognitive domains. A moderate-intensity, 12-week intervention duration, with three weekly sessions, proved adequate. Discussion: It seems that combined rehabilitation training programs are efficient for patients with stroke as these alter neuroplastic conditions due to synergistic or additional onset of action. Future research should investigate combined rehabilitation training programs, with follow-up, to assess how long the recorded improvements last. The protocol of this study is registered in PROSPERO, number CRD42021248533.

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Grip training improves handgrip strength, cognition, and brain white matter in minor acute ischemic stroke patients

Cited by 13 publications

References 40 publications

Aerobic exercises and cognitive function in post-stroke patients: A systematic review with meta-analysis

Aerobic exercises and cognitive function in post-stroke patients: A systematic review with meta-analysis

Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank

Duration and Efficiency of Combined versus Isolated Aerobic Training Interventions in Post-Stroke Cognition: A Systematic Review

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