Grip Strength in Patients with Gastrointestinal Diseases

Abstract

We sought to elucidate factors contributing to the grip strength (GS) decline in patients with gastrointestinal diseases (Ga-Ds, n = 602, 379 males, median age = 72 years). The GS decline in males and females was defined as <28 kg and <18 kg, respectively, following the current Asian guidelines. The median GS (male) was 28.8 kg, and GS decline (male) was found in 169 patients (44.6%). The median GS (female) was 17.5 kg, and GS decline (female) was found in 122 patients (54.7%). Advanced cancer was identified in 145 patients (24.1%). In terms of the univariate analysis of parameters of the GS decline, age (p < 0.0001), gender (p = 0.0181), body mass index (BMI, p = 0.0002), ECOG-PS (p < 0.0001), SARC-F score (p < 0.0001), hemoglobin value (p < 0.0001), total lymphocyte count (p < 0.0001), serum albumin value (p < 0.0001), C reactive protein (CRP) value (p < 0.0001), and estimated glomerular filtration rate were statistically significant. In terms of the multivariate analysis, age (p < 0.0001), BMI (p = 0.0223), hemoglobin value (p = 0.0186), serum albumin value (p = 0.0284), the SARC-F score (p = 0.0003), and CRP value (p < 0.0001) were independent parameters. In conclusion, the GS decline in patients with Ga-Ds is closely associated with not only the primary factor (i.e., aging) but also secondary factors such as inflammatory factors and nutritional factors.

Accurate SARC-F Score in Patients with Liver Disease

“…are classified as secondary sarcopenia [3,4]. Nutrient metabolism is often altered in patients with gastrointestinal diseases, and nutrient requirements and dietary intake differ from those of healthy individuals [5][6][7][8][9]. In other words, gastrointestinal diseases are considered representative of secondary sarcopenia [10,11].…”

Prognostic Nutritional Index Correlates with Liver Function and Prognosis in Chronic Liver Disease Patients

“…Malnutrition is a condition in which the intake or absorption of nutrients essential for development and the prevention of disease is inadequate [ 1 , 2 ]. Compared to healthy individuals, patients with gastrointestinal diseases often have altered nutrient metabolism [ 3 , 4 , 5 , 6 , 7 ]. In particular, patients with chronic liver diseases (CLDs) frequently become malnourished [ 8 ].…”