Grignard Reaction

Abstract

The Grignard reaction refers to the reaction of Grignard reagents with many kinds of electrophiles, including CO 2 to form carboxylic acid and nitriles or acyl halides to form ketones, carbonyl compounds to form alcohols. Because the Grignard reagent is equivalent to a carbanion, the preparation of Grignard reagent must be carried out in an anhydrous solvent that can dissolve but not react with the generated carbanion species. This reaction has wide application in organic synthesis and is one of the most popular reactions to form carbon‐carbon bonds.