Grignard Exchange Reaction Using a Microflow System:  From Bench to Pilot Plant

Wakami, Hideo; Yoshida, Jun‐ichi

doi:10.1021/op0501500

Cited by 114 publications

(61 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To study the heat exchange principles, a very rapid and exothermic reaction was selected consisting of a Grignard reagent reacting with an acyl chloride (see Scheme 1). Such Grignard reactions are interesting to study [10,21]. For example, Cahiez and Laboue described the reaction of acyl chlorides and Grignard reagents in the presence of catalytic amounts of manganese chloride and copper (I) chloride [22].…”

Section: Concrete Chemical Examplementioning

confidence: 99%

Development of an Industrial Multi‐Injection Microreactor for Fast and Exothermic Reactions – Part II

et al. 2008

View full text Add to dashboard Cite

A Grignard reaction performed in a microreactor is presented. The reaction is of type A (highly exothermic and very rapid) and has a low yield which is attributed to a hot spot formed in the mixing zone of the reactor. The reaction yield could be significantly increased by applying the multi-injection principle, leading to better thermal control in the microreactor. Nevertheless, the microreactor plays a major role in reducing the magnitude of the hot spot. Knowing this, it was possible to design and construct an industrial microreactor with significant advantages such as modularity, high flow rate operation, and low investment expenditure (pumps and flow controller minimization).

show abstract

Section: Concrete Chemical Examplementioning

confidence: 99%

Development of an Industrial Multi‐Injection Microreactor for Fast and Exothermic Reactions – Part II

et al. 2008

View full text Add to dashboard Cite

show abstract

“…However, efficient temperature control is possible using a flow microreactor system, and this process can be carried out continuously without a problem. [41] A 24 h continuous operation of the test plant generated about 15 kg (94 % yield) of the product. This result demonstrates that flow microreactor systems are sufficiently useful for production of chemical substances in industry.…”

Section: Wwwchemsuschemorgmentioning

confidence: 99%

Green and Sustainable Chemical Synthesis Using Flow Microreactors

2010

Self Cite

View full text Add to dashboard Cite

Several features that allow flow microreactors contribute to green and sustainable chemical synthesis are presented: (1) For extremely fast reactions, kinetics often cannot be used because of the lack of homogeneity of the reaction environment when they are conducted in batch macroreactors. Better controllability, by virtue of fast mixing based on short diffusion paths in microreactors, however, leads to a higher selectivity of the products, based on kinetics considerations. Therefore, less waste is produced. (2) Reactions involving highly unstable intermediates usually require very low temperatures when they are conducted in macrobatch reactors. By virtue of short residence times, flow microreactors enable performing such reactions at ambient temperatures, avoiding cryogenic conditions and minimizing the energy required for cooling. (3) By virtue of the precise residence time control, flow microreactors allow to avoid the use of auxiliary substances such as protecting groups, enabling highly atom- and step-economical straightforward syntheses. The development of several test plants based on microreaction technology has proved that flow microreactor synthesis can be applied to the green and sustainable production of chemical substances on industrial scales. (4) Microreactor technology enables on-demand and on-site synthesis, which leads to less energy for transportation and easy recycling of substances.

show abstract

“…Grignard reactions also belong to the most frequently applied organometallic reactions [50] and are well investigated in microreactors [51,52]. They are very rapid reactions (Type A) with highly exothermic heat release (see Scheme 4).…”

Section: Grignard Reaction With Multi-injection Principle For Temperamentioning

confidence: 99%

Harsh Reaction Conditions in Continuous‐Flow Microreactors for Pharmaceutical Production

2009

View full text Add to dashboard Cite

Enhanced transport phenomena are essential for chemical reactions in continuous-flow microstructured equipment with transitional flow regimes. The geometry and cross-section of the smallest channel determines the flow regime, pressure loss, and energy dissipation in the microchannel. Mixing and heat transfer are greatly influenced by the flow regime. Controlled reaction conditions lead to enhanced safety, especially for harsh reaction conditions at elevated temperatures or high concentrations. Safety and operational limits of these regimes are presented for optimized process intensification, with examples of nitration and organometallic reactions.

show abstract

Grignard Exchange Reaction Using a Microflow System: From Bench to Pilot Plant

Cited by 114 publications

References 15 publications

Development of an Industrial Multi‐Injection Microreactor for Fast and Exothermic Reactions – Part II

Development of an Industrial Multi‐Injection Microreactor for Fast and Exothermic Reactions – Part II

Green and Sustainable Chemical Synthesis Using Flow Microreactors

Harsh Reaction Conditions in Continuous‐Flow Microreactors for Pharmaceutical Production

Contact Info

Product

Resources

About