In this paper, we discuss nano sensor-integrated system model for metabolic syndrome estimation with workflow management system. We also represent function modules which can measure the heat metabolism in cell level and analyze it to distinguish condition of cell and human system. As for the evaluation of proposed system, we composed prototype workflows that automate each step of metabolism estimation simulation experiment processes with Kepler Extension model that is useful for distributed collaborative simulation. Through the experimental results, we conclude that the proposed system enhanced distributed workflow execution performance according to the cell metabolism simulation model.