Grid-Based Spatial Index Method for Location-Based Nearest Neighbour Search

Myint, Aung Zaw; Tun, Khin Mo Mo

doi:10.18178/ijfcc.2020.9.2.563

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…For each simulation of a 90 days period, we computed the changes in the number and distribution of cancer cells. We characterized the spatial cell distribution using the uniformity index (UI) [44][45][46]. High UI indicates a homogeneous distribution all over the simulation field, whereas low UI is an indication for cluster formation.…”

Section: The Effect Of Cell Speed and Persistence On Tumor Progressionmentioning

confidence: 99%

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

et al. 2023

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Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a mathematical model wherein cells migrate in two-dimensional space, divide, die or intravasate into the vasculature. Exploring a wide range of speed and persistence combinations, we find that tumor growth positively correlates with increasing speed and higher persistence. As a biologically relevant example, we focused on Golgi fragmentation, a phenomenon often linked to alterations of cell migration. Golgi fragmentation was induced by depletion of Giantin, a Golgi matrix protein, the downregulation of which correlates with poor patient survival. Applying the experimentally obtained migration and invasion traits of Giantin depleted breast cancer cells to our mathematical model, we predict that loss of Giantin increases the number of intravasating cells. This prediction was validated, by showing that circulating tumor cells express significantly less Giantin than primary tumor cells. Altogether, our computational model identifies cell migration traits that regulate tumor progression and uncovers a role of Giantin in breast cancer progression.

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Section: The Effect Of Cell Speed and Persistence On Tumor Progressionmentioning

confidence: 99%

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

et al. 2023

View full text Add to dashboard Cite

show abstract

“…For each simulation of a 90 days period, we computed the changes in the number and distribution of cancer cells. We characterized the spatial cell distribution using the uniformity index (UI) (41)(42)(43). High UI indicates a homogeneous distribution all over the simulation field, whereas low UI is an indication for cluster formation.…”

Section: The Effect Of Cell Speed and Persistence On Tumor Progressionmentioning

confidence: 99%

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

Ghannoum

Fantini

Zahoor

et al. 2022

Preprint

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Few studies so far have investigated the impact of different cell migration traits on tumor progression. To address this, we developed a mathematical model wherein cells migrate in two-dimensional space, divide, die or intravasate into the vasculature. Exploring a wide range of speed and persistence combinations, we find that tumor growth positively correlates with increasing speed and higher persistence. As a biologically relevant example, we focused on Golgi fragmentation induced by depletion of Giantin, a Golgi matrix protein, the downregulation of which correlates with poor patient survival. Applying the migration and invasion traits of Giantin depleted cells to our mathematical model, we predict that loss of Giantin increases the number of intravasating cells. This prediction was validated, by showing that circulating tumor cells express significantly less Giantin than primary tumor cells. Altogether, our computational model identifies cell migration traits that regulate tumor progression and uncovers a role of Giantin in breast cancer progression.

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Understanding Cyber Forensics and Some of Its Tools

Cheluvamurthy¹,

Shashikala²

2019

SSRN Journal

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Grid-Based Spatial Index Method for Location-Based Nearest Neighbour Search

Cited by 3 publications

References 4 publications

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

Understanding Cyber Forensics and Some of Its Tools

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