GrgA as a potential target of selective antichlamydials

Zhang, Huirong; Vellappan, Sangeevan; Tang, May; Bao, Xiaofeng; Fan, Huizhou

doi:10.1101/437285

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Activators Targeting the σ2 Domain1

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2020

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“…GrgA is specific to Chlamydia species, and has not been found in any other organism. Therefore, it might be a good target for developing highly selective anti-chlamydial drugs ( Zhang et al, 2019 ).…”

Section: Activators Targeting the σ2 Domainmentioning

confidence: 99%

The σ Subunit-Remodeling Factors: An Emerging Paradigms of Transcription Regulation

Vishwakarma

Brodolin

2020

Front. Microbiol.

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Transcription initiation is a key checkpoint and highly regulated step of gene expression. The sigma (σ) subunit of RNA polymerase (RNAP) controls all transcription initiation steps, from recognition of the −10/−35 promoter elements, upon formation of the closed promoter complex (RPc), to stabilization of the open promoter complex (RPo) and stimulation of the primary steps in RNA synthesis. The canonical mechanism to regulate σ activity upon transcription initiation relies on activators that recognize specific DNA motifs and recruit RNAP to promoters. This mini-review describes an emerging group of transcriptional regulators that form a complex with σ or/and RNAP prior to promoter binding, remodel the σ subunit conformation, and thus modify RNAP activity. Such strategy is widely used by bacteriophages to appropriate the host RNAP. Recent findings on RNAP-binding protein A (RbpA) from Mycobacterium tuberculosis and Crl from Escherichia coli suggest that activator-driven changes in σ conformation can be a widespread regulatory mechanism in bacteria.

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Section: Activators Targeting the σ2 Domainmentioning

confidence: 99%