Grey matter differences in bipolar disorder: a meta‐analysis of voxel‐based morphometry studies

Selvaraj, Sudhakar; Arnone, Danilo; Job, Dominic; Stanfield, Andrew C.; Farrow, Tom F.D.; Nugent, Allison C.; Scherk, Harald; Gruber, Oliver; Chen, Xiaohua; Sachdev, Perminder S.; Dickstein, Daniel P.; Malhi, Gin S; Ha, Tae Hyon; Ha, Kyooseob; Phillips, Mary L.; McIntosh, Andrew M.

doi:10.1111/j.1399-5618.2012.01000.x

Cited by 323 publications

(183 citation statements)

References 62 publications

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“…This finding goes against those of other VBM studies of patients with bipolar disorder, meta‐analyses of which have found the anterior cingulate cortex, the insula, and the inferior frontal cortex to show volume reductions, among other areas 22, 39, 40. The likeliest explanation of our failure to detect differences is the use of a restrictive threshold of at a P = 0.01 corrected.…”

Section: Discussioncontrasting

confidence: 78%

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Amann

Canales‐Rodríguez

Madre

et al. 2015

Acta Psychiatr Scand

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ObjectiveBrain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent.MethodForty‐five patients meeting DSM‐IV and RDC criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel‐based morphometry (VBM).ResultsAnalyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five.ConclusionThe findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder.

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Section: Discussioncontrasting

confidence: 78%

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Amann

Canales‐Rodríguez

Madre

et al. 2015

Acta Psychiatr Scand

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“…[21][22][23][24][25] Other studies suggest that structural brain changes are found mainly in the frontal, temporal, and limbic white matter (WM) regions. [26][27][28][29][30][31] WM abnormalities have been widely detected in subjects with the pathophysiological features of BD, especially with diffusion tensor imaging (DTI) techniques. 29 Diffusion imaging principles are based on measurement of the motion of water molecules within tissues.…”

Section: Introductionmentioning

confidence: 99%

Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

Duarte

Silva²,

Goldani³

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To review the available data on diffusion tensor imaging (DTI) of subjects with bipolar disorder (BD), with a particular focus on fractional anisotropy (FA) in white matter (WM) tracts. Methods: The PubMed/MEDLINE database was searched for relevant articles, which were included in a systematic review of the literature. FA reductions and WM abnormalities were divided anatomically into three groups: commissural tracts, association tracts, and projection tracts. Results: Eighteen studies met the inclusion criteria. The corpus callosum was the main impaired commissural tract as demonstrated by FA reductions. Five studies reported FA reductions in the cingulum. Two studies reported decreased FA in the anterior thalamic radiation, and one in the corticospinal tract. Conversely, three studies found increased FA values in WM tracts involved in BD pathophysiology. Conclusion: Despite considerable heterogeneity, these results indicate a direct link between executive cognitive functioning and abnormal WM microstructural integrity of fronto-limbic tracts in patients with remitted BD, providing further evidence of the neuronal disruption that underlies BD symptomatology.

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“…A large number of region-based and voxel-based approaches has already been applied to identify the structural abnormalities associated with SCZ and BD (Arnone et al 2009;Ellison-Wright & Bullmore, 2010;Yu et al 2010;Bora et al 2012;Selvaraj et al 2012). Whole-brain voxel-based morphometry (VBM) studies highlighted overlapping areas of grey matter (GM) reduction in SCZ and BD compared with HC, mainly located in bilateral insula and anterior cingulate cortex.…”

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confidence: 99%

Neuroanatomical voxel-based profile of schizophrenia and bipolar disorder

Maggioni

Altamura

Brambilla

2016

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences appears in each issue of the Journal to stress the relevance of epidemiology for behavioral neurosciences, reporting the results of studies that explore the use of an epidemiological approach to provide a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.The ultimate aim is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Although schizophrenia (SCZ) and bipolar disorder (BD) share elements of pathology (Ellison-Wright and Bullmore, 2009), the neural mechanisms underlying these disorders are still under investigation. Up until now, many neuroimaging studies investigated the brain structural differences of SCZ and BD compared with healthy controls (HC), trying to identify the possible neuroanatomical markers for the two disorders. However, just a few studies focused on the brain structural changes between the two diagnoses. The present review summarises the findings of the voxel-based grey matter (GM) comparisons between SCZ and BD, with the objective to highlight the possible consistent anatomical differences between the two disorders. While the comparisons between patients and HC highlighted overlapping areas of GM reduction in insula and anterior cingulate cortex, the SCZ-BD comparisons suggest the presence of more generalised GM deficits in SCZ compared with BD. Indeed, in a number of studies, SCZ patients showed lower GM volumes than BD patients in fronto-temporal cortex, thalamus, hippocampus and amygdala. Conversely, only a couple of studies reported GM deficits in BD compared with SCZ, both at the level of cerebellum. In summary, the two disorders exhibit both common and specific neuroanatomical characteristics, whose knowledge is mandatory to develop innovative diagnostic and treatment strategies. (Email: marcella.bellani@univr.it; paolo.brambilla1@unimi.it)Epidemiology and Psychiatric Sciences (2016), 25, 312-316.

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Grey matter differences in bipolar disorder: a meta‐analysis of voxel‐based morphometry studies

Abstract: Bipolar disorder is consistently associated with reductions in right prefrontal and temporal lobe grey matter. Reductions elsewhere may be obscured by clinical and methodological heterogeneity.

Cited by 323 publications

References 62 publications

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder

Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

Neuroanatomical voxel-based profile of schizophrenia and bipolar disorder

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