Grey matter alterations in migraine: A systematic review and meta-analysis

Jia, Zhihua; Yu, Shengyuan

doi:10.1016/j.nicl.2017.01.019

Cited by 149 publications

(154 citation statements)

References 82 publications

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“…A previous study involving both episodic and chronic migraineurs has similarly demonstrated that the temporal lobe is involved in increased cortical thickness covariance compared to controls . Similarly, the frontal lobe has previously been identified as one of the regions with cortical changes in migraine . Our results further corroborate the importance of the temporal and frontal lobes in CM pathophysiology.…”

Section: Discussionsupporting

confidence: 88%

Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine – A Pilot Study

et al. 2018

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Objectives.-The objectives of this cross-sectional pilot study were threefold: to identify regions of cortical thickness that differentiate chronic migraine (CM) from controls, to assess group differences in interregional cortical thickness covariance, and to determine group differences in associations between clinical variables and cortical thickness.Background.-Cortical thickness alterations in relation to clinical features have not been adequately explored in CM. Assessment of this relationship can be useful to describe cortical substrates for disease progression in migraine and to identify clinical variables that warrant management emphasis.Methods.-Thirty CM cases (mean age 40 years; male-to-female 1:4) and 30 sex-matched healthy controls (mean age 40 years) were enrolled. Participants completed self-administered and standardized questionnaires assessing headache-related clinical features and common psychological comorbidities. T1-weighted brain images were acquired on a 3T MRI. A whole-brain cortical thickness analysis was performed. Additionally, correlations between all brain regions were assessed to examine interregional cortical thickness covariance. Interactions were analyzed to identify clinical variables that were significantly associated with cortical thickness.Results.-The whole brain cortical thickness analysis revealed no significant differences between CM patients and controls. However, significant associations between clinical features and cortical thickness were observed for the patients only. These associations included the right superior temporal sulcus (R 2 = 0.72, P = .001) and the right insula (R 2 = 0.71, P = .002) with distinct clinical variables ie, longer history of CM, posttraumatic stress disorder (PTSD), sleep quality, pain self-efficacy, and somatic symptoms. Higher interregional cortical covariance was found in CM compared to controls (OR = 3.1, CI 2.10-4.56, P < .0001), such that cortical thickness between regions tended to be more correlated in patients, particularly in the temporal and frontal lobes.Conclusion.-CM patients have significantly greater cortical covariance compared to controls. Cortical thickness in CM patients was predominantly accounted for by CM duration, PTSD, and poor sleep quality, while improved pain self-efficacy buffered cortical thickness. While it is important to address all CM features and comorbidities, it may be useful to emphasize optimizing the management of certain clinical features that contribute to cortical abnormalities including managing PTSD, early management to shorten duration of CM, and improving pain self-efficacy and sleep quality. Abbreviations: CM chronic migraine, CSF cerebrospinal fluid, EM episodic migraine, GAD-7 generalized anxiety disorder-7, GM gray matter, ICHD International Classification of Headache Disorders, IQR interquartile range, MIDAS migraine disability assessment, MOH medication overuse headache, PC-PTSD primary care posttraumatic stress disorder, PCS pain catastrophizing scale, PHQ-9 patient health questionnaire-9, ...

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Section: Discussionsupporting

confidence: 88%

Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine – A Pilot Study

et al. 2018

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“…The postcentral gyrus, paracentral lobule, and precentral gyrus are involved in sensorimotor networks, and a previous study found functional abnormalities and abnormal cortical thickness or gray matter volume in the sensorimotor network in migraineurs [9,41,42]. Gray matter volume decreases in the right anterior cingulate are related to the estimated frequency of headache attacks [43]. The temporal pole has been demonstrated to participate in pain processing and multisensory integration [3,35,36].…”

Section: Discussionmentioning

confidence: 97%

Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura

Qin

et al. 2020

Preprint

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Background: Migraine is a severe and disabling brain disorder, and the exact neurological mechanisms remain unclear. Migraineurs have altered pain perception, and headache attacks disrupt their sensory information processing and sensorimotor integration. The altered functional connectivity (FC) of sub-regions of sensorimotor brain areas with other brain cortex associated with migraine needs further investigation. Methods: Forty-eight migraine without aura (MWoAs) during the interictal phase and 48 age- and sex-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. We utilized seed-based functional connectivity analysis to investigate whether patients exhibited abnormal functional connectivity between sub-regions of sensorimotor brain areas and cortex regions. Results : We found that MWoAs exhibited disrupted FC between the sensorimotor areas and the visual cortex, temporal cortex, posterior parietal lobule, prefrontal areas, precuneus, cingulate gyrus, sensorimotor areas proper and cerebellum areas compared with healthy controls. In addition, the clinical data of the patients, such as disease duration, pain intensity and HIT-6 score, were negatively correlated with these impaired FC s. Conclusion : In MWoAs, the FCs between the sensorimotor brain areas and other brain regions was reduced. These disrupted FCs might contribute to abnormalities in visual processing, multisensory integration, nociception processing, spatial attention and intention and dysfunction in cognitive evaluation and modulation of pain. Recurrent headache attacks might lead to the disrupted network between L M1 (primary motor cortex) and temporal regions and between L S1 (primary somatosensory cortex) and temporal regions. Pain sensitivity and patient quality of life are closely tied to the abnormal functional connectivity between sensorimotor regions and other brain regions.

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“…In particular, VBM data established that the GMV was decreased in the anterior cingulate cortex, insula, amygdala, parietal operculum, middle and inferior frontal gyrus [13]. In addition, regions with reduced grey matter density are located in bilateral insula, motor premotor, prefrontal, cingulate cortex, right posterior parietal cortex and orbitofrontal cortex [14].…”

Section: Discussionmentioning

confidence: 98%

Brain structural abnormalities in migraine patients: an observational study

Vl¹,

Corallo²,

Ruvolo³

et al. 2020

Preprint

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Background: Migraine is a common neurological disorder, characterized by a complex physiopathology. We analyzed brain structural differences in migraine and the possible pathogenetic mechanism underlying this disease.Methods: We assessed brain structure in migraine patients, 14 with aura (MA) and 14 migraine without aura, (MO) compared with health subjects (HS) by using (VBM) approach.Results: Total cerebral GMV showed a significant difference between MA and HS (p=0.03), and between MO and HS (p=0.003). In addition, there was a significative difference trend between MA and MO (p=0.05) groups. We found three clusters of regions which showed significant GMV reduction in MA compared with MO. MA subjects showed a decrease of GMV in 4 clusters if compared with HS, and MO subjects showed a decrease of GMV in 3 clusters if compared with HS. We observed that MA and MO patients had a significant reduction of GMV in the frontal and temporal lobe and the cerebellum, if compared to HS. The bilateral fusiform gyrus and the cingulate gyrus were increased in MO patients compared with HS.Conclusion: Our findings could provide a new instrumental approach to understand possible differences in the pathogenesis of 2 type of migraine.

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Grey matter alterations in migraine: A systematic review and meta-analysis

Cited by 149 publications

References 82 publications

Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine – A Pilot Study

Clinical Features Contributing to Cortical Thickness Changes in Chronic Migraine – A Pilot Study

Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura

Brain structural abnormalities in migraine patients: an observational study

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