Grewia asiatica L., a Food Plant with Multiple Uses

Zia-Ul-Haq, Muhammad; Stanković, Milan; Rızwan, Komal; Feo, Vincenzo De

doi:10.3390/molecules18032663

Cited by 65 publications

(55 citation statements)

References 22 publications

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“…It is estimated that approximately 80% of the population in developing countries rely on traditional medicines for their primary health care [8, 9]. In China, traditional herbal preparations account for 30 to 50% of the medicines consumed [10].…”

Section: Introductionmentioning

confidence: 99%

Anticholangiocarcinoma activity and toxicity of the Kaempferia galanga Linn. Rhizome ethanolic extract

Amuamuta

Plengsuriyakarn

Na‐Bangchang

2017

BMC Complement Altern Med

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BackgroundCholangiocarcinoma (CCA) is an important public health problem in several tropical and subtropical parts of the world particularly Thailand. Chemotherapy of CCA is largely ineffective and discovery and development of effective alternative drugs is urgently needed. The objective of the study was to confirm the anti-CCA potential as well as toxicity of the crude extract of Kaempferia galangal Linn. (rhizome) both in vitro and in animal models.MethodsThe ethanolic extract of K. galanga Linn. rhizome, ethyl-p-methoxycinnamate (EPMC) and 5-fluorouracil (5-FU) were evaluated for their cytotoxic activities against CCA cell line (CL-6) using MTT cell proliferation assay. Acute and subacute toxicity of the extract were evaluated in ICR (Imprinting Control Region) mice according to the OECD (International Organization for Economic Co-operation and Development) Guideline. Anti-CCA activity was evaluated in CCA- xenografted nude mice.ResultsResults of cytotoxicity test showed moderate activity of the extract and EPMC with median (95% confidence interval: 95% CI) 50% inhibitory concentration (IC50) of 64.2 (57.76–72.11) and 49.19 (48.16–52.29) μg/ml, respectively. The IC50 of 5-FU was 107.1 (103.53–109.64) μg/ml. The selectivity index (SI) values for the extract, EPMC and 5-FU against human normal cell line (OUMS) and cancer cell line (CL-6) were 2.2, 2.09 and 1.31, respectively. Toxicity testing revealed no overt toxic effect up to the maximum single oral dose of 5000 mg/kg body weight and up to daily dose of 1000 mg/kg body weight for 30 days. The extract at the maximum tolerated dose level of 1000 mg/kg body weight for 30 days exhibited promising anti-CCA activity in CL6-xenografted nude mice as determined by inhibitory activity on tumor growth (58.41%) and lung metastasis (33.3%), as well as prolongation of survival time (62 days).ConclusionThe K. galangal Linn. rhizome extract and its bioactive compound EPMC exhibited moderate cytotoxic activity against human CCA tumor (CL-6) cell line. Results of toxicity testing suggest that the extract was well tolerated up to the maximum single oral dose of 5000 mg/kg body weight and daily dose of 1000 mg/kg body weight for 30 days. The extract exhibited promising anti-CCA activity in CL6-xenografed nude mice as determined by significant inhibitory activity on tumor growth and lung metastasis, as well as prolongation of survival time.

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Section: Introductionmentioning

confidence: 99%

Anticholangiocarcinoma activity and toxicity of the Kaempferia galanga Linn. Rhizome ethanolic extract

Amuamuta

Plengsuriyakarn

Na‐Bangchang

2017

BMC Complement Altern Med

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“…Zia‐Ul‐Haq et al . () noted that Grewia asiatica has a high content of antioxidants such as vitamin C, total phenolics, flavonoids, tannins and anthocyanins. In the present study, we observed the effect of edible coatings on the antioxidant content of phalsa.…”

Section: Resultsmentioning

confidence: 99%

“…Its use as an herbal medicine for the treatment of various diseases such as cancer, aging, fever, rheumatism and diabetes is now well established (Zia‐Ul‐Haq et al . ). The fruit is nonclimacteric with extremely short shelf life.…”

Section: Introductionmentioning

confidence: 97%

RSM-Based Optimization of Edible-Coating Formulations for Preserving Post-Harvest Quality and Enhancing Storability of Phalsa (Grewia asiaticaL.)

Dave

Rao

Nandane³

2015

Journal of Food Processing and Preservation

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The fruit of Grewia asiatica L., which is locally known as "phalsa," contains high amounts of phenolics and anthocyanins. However, because of its perishable nature, this fruit remains underutilized. Hence, it becomes necessary to employ ways that will extend the shelf life of this fruit until it reaches the consumers. Application of edible coatings provides a cheaper and easy method to protect horticulture products during postharvest handling. Response surface methodology was used to optimize the concentrations of edible-coating formulation comprising of Soy Protein Isolate (SPI), Olive oil, Hydroxy Propyl Methyl Cellulose (HPMC) and Potassium Sorbate. The study suggested SPI 3.45%, HPMC 0.40%, olive oil 1% and potassium sorbate 0.25% to be the most suitable for phalsa. Three optimized coating emulsions, including the above suggested emulsion, were selected for further biochemical studies of phalsa. The results obtained from this study revealed that the optimized coatings could successfully retain the quality attributes of phalsa. PRACTICAL APPLICATIONSEdible coatings on fresh fruits can provide an alternative for modified atmosphere storage by reducing quality changes and quantity losses during their postharvest storage. The composition and concentration of edible coatings plays a major role in this process. The present study used response surface methodology (RSM) to optimize the concentrations of soy protein isolate, hydroxy propyl methyl cellulose, olive oil and potassium sorbate in edible coatings for phalsa. The results of present investigation offer suggestions for possible formulation of composite edible coating that can be used for enhancing the postharvest quality and shelf life of phalsa. Because the study is based on RSM optimization of edible-coating formulations, it helps predict the exact concentration of each component of a coating emulsion and its effect on the physiology of the fruit. This can help to formulate edible coatings on commercial basis, in the long run.

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“…Grewia asiatica L. (Family: Malvaceae) is a plant of medicinal importances though it is cultivated mainly for its fruits (Zia-Ul- Haq et al, 2013). It is commonly known as Phalsa.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant and Sedative-hypnotic Activities of Methanolic Extract of Grewia asiatica Linn. Leaves in Mice

et al. 2019

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Grewia asiatica (Family-Malvaceae), known as Phalsa in Bangladesh, is also native to India, Nepal, Pakistan, Cambodia and Thailand. The plant has a long history of traditional uses. The present investigation was designed to evaluate acute toxicity test, antidepressant and sedative-hypnotic activities of the methanolic extract of the leaves of G. asiatica. In acute toxicity test, methanolic soluble fraction of the plant extract of G. asiatica showed no significant changes in the body weight between the control and treated group at the doses of 1000, 2000 and 3000 mg/kg body weight. The extract could not significantly reduce immobility time in comparison with control group and standard drug (Nortriptyline) treated group in forced swimming and tail suspension tests. Sedative-hypnotic activity was evident at the doses of 100 and 200 mg/kg body weight after observing in hole board test. Sedative-hypnotic activity of short duration of action was also evident in hole cross and open field test. Bangladesh Pharmaceutical Journal 22(2): 185-191, 2019

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Grewia asiatica L., a Food Plant with Multiple Uses

Cited by 65 publications

References 22 publications

Anticholangiocarcinoma activity and toxicity of the Kaempferia galanga Linn. Rhizome ethanolic extract

Anticholangiocarcinoma activity and toxicity of the Kaempferia galanga Linn. Rhizome ethanolic extract

RSM-Based Optimization of Edible-Coating Formulations for Preserving Post-Harvest Quality and Enhancing Storability of Phalsa (Grewia asiaticaL.)

Antidepressant and Sedative-hypnotic Activities of Methanolic Extract of Grewia asiatica Linn. Leaves in Mice

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