Greffe de chondrocytes autologues dans le traitement des pertes de substance condylienne du genou

Robert, H.; Bahuaud, J; Kerdiles, N.; Passuti, N.; Capelli, M.; Pujol, Jordi; Hartman, David L.; Locker, B.; Hulet, C.; Hardy, Philippe; Coudane, H.; Rochverger, A.; Francheschi, J P

doi:10.1016/s0035-1040(07)73255-5

Cited by 17 publications

(4 citation statements)

References 30 publications

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“…Articular cartilage allows humans, along with other animals, to walk without pain. Pathological events and disorders associated with osteoarthritis can cause cartilage loss and pain during movement in humans [172][173][174][175][176]. The presence of cartilage adjacent to joint surfaces serves as a lubricant and absorbs the body's weight during physical activity.…”

Section: Bioprinting Of Tissues 31 Cartilage Regenerationmentioning

confidence: 99%

Advancement in Regenerative Medicine Along with Tissue Engineering: Medical Revolution & Transformation: A Review

2024

IJFMR

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Congenital abnormalities, trauma, and infections all cause tissue and organ loss in both humans and animals. The human being's body has a lower regenerating capability than urodele amphibians, sometimes known as salamanders. Hundreds of thousands of people worldwide would benefit greatly from the ability to replace organs and tissues on demand. Historically, transplanting intact organs and tissues has served as the foundation for replacing damaged and sick body components. Dependence on transplant has resulted in waiting list of persons wanting organs and tissues donated, and supply is often insufficient. To provide risk-free and reputable sources, Scientists together with clinicians attempts to develop medications and procedures for regenerating tissue and, in some circumstances, creating completely new tissue. Tissues engineering, often known as regenerative medicine, is a branch of life sciences that integrates engineering techniques with biological concepts in order to create new organs as well as tissues or to stimulate the regenerative process of injured or diseased tissues. Significant advances are being made not only in regenerative medicine (RM), but also in tissue engineering, which will have a significant influence on natural 3D bioprinting (BP) of organs as well as tissues. 3D BP has tremendous potential not only in tissue BP, but also for artificial organs. This paper examines Recent advancements into regenerative medicine including tissues engineering can assist from 3D BP and conversely. Before 3D bioprinting becomes extensively employed to generate organotypic constructions foR RM, several hurdles must be solved.

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Section: Bioprinting Of Tissues 31 Cartilage Regenerationmentioning

confidence: 99%

Advancement in Regenerative Medicine Along with Tissue Engineering: Medical Revolution & Transformation: A Review

2024

IJFMR

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“…Finally, carboxylesterase (CE) converts the prodrug irinotecan (CPT-11) to the potent topoisomerase inhibitor SN-38. [278] …”

Section: Engineering Stem Cells For Cancer Therapymentioning

confidence: 99%

“…[278] Furthermore, owing to the tunability of nanoparticles, their surfaces can be specifically modified to optimize properties such as stability, solubility, and targeting for cancer applications. [288] Despite the promise that nanotechnology holds for drug delivery, the use of nanoparticles in vivo and especially in the clinic have been confounded by serious limitations such as rapid clearance by the renal system, inefficient targeting and infiltration, and an inability to target micrometastases.…”

Section: Engineering Stem Cells For Cancer Therapymentioning

confidence: 99%

“…[288] Despite the promise that nanotechnology holds for drug delivery, the use of nanoparticles in vivo and especially in the clinic have been confounded by serious limitations such as rapid clearance by the renal system, inefficient targeting and infiltration, and an inability to target micrometastases. [278,288] To this end, stem cell-based drug delivery for cancer therapy offers a unique strategy with which to overcome these barriers. [289] In particular, stem cells can be loaded with nanoparticles carrying the particular drug of interest and injected in vivo, where they can then specifically migrate to the tumor and its metastases and deposit the loaded nanoparticles in close proximity or within the tumor.…”

Section: Engineering Stem Cells For Cancer Therapymentioning

confidence: 99%

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Engineering Stem Cells for Biomedical Applications

Yin

Han

Lee

2015

Adv Healthcare Materials

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Stem cells are characterized by a number of useful properties, including their ability to migrate, differentiate, and secrete a variety of therapeutic molecules such as immunomodulatory factors. As such, numerous pre-clinical and clinical studies have utilized stem cell-based therapies and demonstrated their tremendous potential for the treatment of various human diseases and disorders. Recently, efforts have focused on engineering stem cells in order to further enhance their innate abilities as well as to confer them with new functionalities, which can then be used in various biomedical applications. These engineered stem cells can take on a number of forms. For instance, engineered stem cells encompass the genetic modification of stem cells as well as the use of stem cells for gene delivery, nanoparticle loading and delivery, and even small molecule drug delivery. The present Review gives an in-depth account of the current status of engineered stem cells, including potential cell sources, the most common methods used to engineer stem cells, and the utilization of engineered stem cells in various biomedical applications, with a particular focus on tissue regeneration, the treatment of immunodeficiency diseases, and cancer.

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