The novel coronavirus, the subsequent shutdown and other measures taken to reduce infections, have greatly affected social work practice. At the same time, they have greatly affected people already in marginal, precarious, excluded and oppressed situations, with whom social workers often work. Many of the contributions for our special issue dealt with challenges, innovations, and methods for social work practice. This section contains a collection of contributions from four continents, ranging from rural islands to metropolitan urban landscapes. They challenge the practice-theory gap, as they are reflections on practice written by psychotherapists, health care social workers, independent visitors, community workers, doctoral students, professors, researchers and practitioners. The essays underline the importance, and "essentiality" of social work during a global health crisis like this. They illustrate social work practice with a range of different population groups, literarily from cradle to grave. We believe that this collection of essays gives a provocative picture of social work practice under the shadow of the virus. During our discussions of these 14 essays, we were struck by differences between contexts as well as the commonalities among them. We highlight three themes often captured here; digital practice, mutual aid, and professional self-care.