This article analyzes the strengths and weaknesses of United Nation's "Framework for the Implementation of Education for Sustainable Development" in the context of Global South (GS). Its strengths are that the theory of Education for Sustainable Development (ESD) system is very scientific and integrated, and the monitoring method is also very quantitative and specific. The weaknesses are that the ESD system designed by UNESCO is not closely connected with the local talent evaluation system of each country, does not pay enough attention to economy, and counts too much on education, which means that it is difficult to attract wide attention of the people in GS areas and cannot really drive people to learn the concept of sustainable development.