Greenhouse and field evaluation of a novel HPPD-inhibiting herbicide, QYM201, for weed control in wheat

Abstract

QYM201, 1-(2-chloro-3-(3-cyclopropyl-5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-6-(trifluoromethyl)phenyl)piperidin-2-one), is a newly developed HPPD- (4-hydroxyphenylpyruvate dioxygenase; EC 1.13.11.27) inhibiting herbicide for weed control. Experiments were carried out to determine the effect of QYM201 on weeds and its safety for wheat in the glasshouse and field. The results indicated that at doses of 90 and 135 g active ingredient (a.i.) ha−1 QYM201 was highly effective against both grass and broadleaf weeds, such as Alopecurus aequalis Sobol., Alopecurus japonicus Steud, and Capsella bursa-pastoris Medic. In a wheat hybrid tolerance experiment, QYM201 showed a high level of safety for most of the 17 tested wheat hybrids, and the SI values reached ≥5.7 in the selectivity index study. To determine application rules for QYM201, field experiments were conducted in 2016 and 2017. During this time, 90 to 270 g a.i. ha−1 post-emergence herbicide application (POST) was sufficient to supply satisfactory all-season control of Alopecurus aequalis Sobol., Descurainia sophia [L.] Schur., and Malachium aquaticum (L.) Fires. No damage to wheat plants was observed. In order to increase wheat yield and deliver effective weed control, a dosage of 90 to 180 g a.i. ha−1 is suggested. In conclusion, the herbicide QYM201 is safe to use in wheat fields to control winter weeds.

Molecular mechanism of resistance to mesosulfuron-methyl in shortawn foxtail (Alopecurus aequalis) from China

“…Therefore, although the susceptibility of the R population to isoproturon seemed to have decreased compared with the S population (RI < 2), both populations could still be effectively controlled by its application at the label rates. Isoproturon applied in combination or rotation with herbicides with different MOAs, such as the novel 4-hydroxyphenylpyruvate dioxygenase inhibitor cypyrafluone (Zhang et al 2019), may be an ideal alternative to delay the evolution of resistance in A. aequalis. The application of the P450 inhibitor malathion or the GST inhibitor NBD-Cl alone did not have a significant effect on the growth of both S and R plants (data not shown).…”

Survey on the Recent Advances in 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibition by Diketone and Triketone Derivatives and Congeneric Compounds: Structural Analysis of HPPD/Inhibitor Complexes and Structure–Activity Relationship Considerations

“…It is very important to note that identification of new herbicides for weed control on wheat fields is needed, in particular in China where resistant weeds emerged and affect wheat yield and quality. Worth noting, the recent introduction of pyrazole herbicides bipyrazone (Figure 1) 22 and QYM201 (also referred to as cypyrafluone, Figure 11) 30 in greenhouse and field experiments opened new avenues for the postemergence treatment of resistant broadleaf weeds in winter wheat fields, with QYM201 preferred for its broad-spectrum herbicide activity in comparison to bipyrazone.…”

Cypyrafluone, a 4-Hydroxyphenylpyruvate Dioxygenase Inhibitor to Control Weed in Wheat Fields

“…As a postemergence (POST) herbicide, cypyrafluone is applied at 135–180 g of active ingredient (a.i.) ha –1 , causing typical foliar whitening (bleaching) to susceptible weeds before death. , As weeds in wheat fields are rapidly evolving resistance to acetyl-coenzyme A carboxylase (ACCase, EC.6.4.1.2) inhibitors, acetolactate synthase (ALS, EC.2.2.1.6) inhibitors and synthetic auxins, cypyrafluone, as a bleaching herbicide, showed a great promise for resistant weed management in wheat fields, especially for resistant cool-season grass weed species of A. aequalis, A.…”

“…ha −1 , causing typical foliar whitening (bleaching) to susceptible weeds before death. 1,2 As weeds in wheat fields are rapidly evolving resistance to acetyl-coenzyme A carboxylase (ACCase, EC.6.4.1.2) inhibitors, acetolactate synthase (ALS, EC.2.2.1.6) inhibitors and synthetic auxins, 3 cypyrafluone, as a bleaching herbicide, showed a great promise for resistant weed management in wheat fields, especially for resistant coolseason grass weed species of A. aequalis, A. japonicus, and A. myosuroides in China. Meanwhile, the degradation of cypyrafluone in soils was rapid, with 50% dissipation (DT 50 ) of 16.1−23.1 days simulated under stable conditions in the laboratory.…”