Greener nanoscience: Piper betel leaf extract mediated synthesis of CaO nanoparticles and evaluation of its antibacterial and anticancer activity

Yoonus, Jumna; Resmi, R.; Beena, B.

doi:10.1016/j.matpr.2020.05.246

Cited by 19 publications

(11 citation statements)

References 18 publications

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“…The most frequently studied Gram-negative bacteria were laboratory strains of E. coli and P. aeruginosa with MIC range from 0.03 to 0.4% and 0.05–0.4%, respectively [ 12 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Meanwhile, the lowest MIC (0.0156%) among Gram-negative bacteria was documented for clinical isolates of P. aeruginosa MβL(+) 3, A. baumannii MβL(+) 2, and P. aeruginosa MβL(+) 3 [ 29 ].…”

Section: Antibacterial Property Of Betel Leavesmentioning

confidence: 99%

“…Meanwhile, the lowest MIC (0.0156%) among Gram-negative bacteria was documented for clinical isolates of P. aeruginosa MβL(+) 3, A. baumannii MβL(+) 2, and P. aeruginosa MβL(+) 3 [ 29 ]. Additionally, S. aureus was the most commonly used Gram-negative bacteria to screen the antibacterial effect of betel leaves with MIC range from 0.00025 to 0.15% [ 12 , 24 , 25 , 26 , 27 , 28 ]. The lowest MIC among Gram-positive bacteria was recorded for an oral pathogen Streptococcus gordonii DMST 38731 (0.00005%) [ 30 ].…”

Section: Antibacterial Property Of Betel Leavesmentioning

confidence: 99%

“…Another study also developed the green synthesis of CaO nanoparticles using the water extract of betel leaves. It showed maximum and minimum activity against E. coli and Streptococcus mutans , respectively [ 28 ]. Additionally, BLEO based nanoemulsion was observed to be effective against five strains of foodborne pathogens and can be used as a promising natural antibacterial agent in the food system [ 26 ].…”

Section: Antibacterial Property Of Betel Leavesmentioning

confidence: 99%

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Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

et al. 2021

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Piper betle (L) is a popular medicinal plant in Asia. Plant leaves have been used as a traditional medicine to treat various health conditions. It is highly abundant and inexpensive, therefore promoting further research and industrialization development, including in the food and pharmaceutical industries. Articles published from 2010 to 2020 were reviewed in detail to show recent updates on the antibacterial and antifungal properties of betel leaves. This current review showed that betel leaves extract, essential oil, preparations, and isolates could inhibit microbial growth and kill various Gram-negative and Gram-positive bacteria as well as fungal species, including those that are multidrug-resistant and cause serious infectious diseases. P. betle leaves displayed high efficiency on Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, Gram-positive bacteria such as Staphylococcus aureus, and Candida albicans. The ratio of MBC/MIC indicated bactericidal and bacteriostatic effects of P. betle leaves, while MFC/MIC values showed fungicidal and fungistatic effects. This review also provides a list of phytochemical compounds in betel leaves extracts and essential oils, safety profiles, and value-added products of betel leaves. Some studies also showed that the combination of betel leaves extract and essential oil with antibiotics (streptomycin, chloramphenicol and gentamicin) could provide potentiating antibacterial properties. Moreover, this review delivers a scientific resume for researchers in respected areas and manufacturers who want to develop betel leaves-based products.

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Section: Antibacterial Property Of Betel Leavesmentioning

confidence: 99%

Section: Antibacterial Property Of Betel Leavesmentioning

confidence: 99%

Section: Antibacterial Property Of Betel Leavesmentioning

confidence: 99%

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Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

et al. 2021

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“…Moreover, IC 50 was 6.73 ± 0.4, 25.8 ± 2.9, 11.4 ± 2.1, and 19.3 ± 3.8 µg/mL for LSM2, LSM5, LSMGd, and LSMSm, respectively. The presented values ascribed to IC 50 for the LSM samples is lower than Ag-NPs at the concentration of 75 μg/mL [ 32 ], and nano CaO of 92.08 µg/mL [ 33 ] inhibits HepG-2 cell proliferation at about 50% (IC 50 ) after 48 h of treatment. Besides, Priya et al [ 34 ] demonstrated that the amount of biogenic silver nanoparticles synthesized using chitosan needed to decrease the cell viability of HepG2 cells to 50% of the initial population (IC 50 ) was 48 ± 1.0 μg/mL, and the doxorubicin (standard) needed to reduce the viability of HepG2 cells to 50% of the initial population was 16 ± 1.0 μg/mL.…”

Section: Resultsmentioning

confidence: 99%

A Robust and Highly Precise Alternative against the Proliferation of Intestinal Carcinoma and Human Hepatocellular Carcinoma Cells Based on Lanthanum Strontium Manganite Nanoparticles

et al. 2021

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In this report, lanthanum strontium manganite at different Sr2+ ion concentrations, as well as Gd3+ or Sm3+ ion substituted La0.5−YMYSr0.5MnO3 (M = Gd and Sm, y = 0.2), have been purposefully tailored using a sol gel auto-combustion approach. XRD profiles confirmed the formation of a monoclinic perovskite phase. FE-SEM analysis displayed a spherical-like structure of the La0.8Sr0.2MnO3 and La0.3Gd0.2Sr0.2MnO3 samples. The particle size of the LSM samples was found to decrease with increased Sr2+ ion concentration. For the first time, different LSM concentrations were inspected for their cytotoxic activity against CACO-2 (intestinal carcinoma cells) and HepG-2 (human hepatocellular carcinoma cells). The cell viability for CACO-2 and HepG-2 was assayed and seen to decrease depending on the Sr2+ ion concentration. Half maximal inhibitory concentration IC50 of CACO-2 cell and HepG-2 cell inhibition was connected with Sr2+ ion ratio. Low IC50 was noticable at low Sr2+ ion content. Such results were correlated to the particle size and the morphology. Indeed, the IC50 of CACO-2 cell inhibition by LSM at a strontium content of 0.2 was 5.63 ± 0.42 µg/mL, and the value increased with increased Sr2+ ion concentration by up to 0.8 to be = 25 ± 2.7 µg/mL. Meanwhile, the IC50 of HepG-2 cell inhibition by LSM at a strontium content of 0.2 was 6.73 ± 0.4 µg/mL, and the value increased with increased Sr2+ ion concentration by up to 0.8 to be 31± 3.1 µg/mL. All LSM samples at different conditions were tested as antimicrobial agents towards fungi, Gram positive bacteria, and Gram negative bacteria. For instance, all LSM samples were found to be active towards Gram negative bacteria Escherichia coli, whereas some samples have presumed antimicrobial effect towards Gram negative bacteria Proteus vulgaris. Such results confirmed that LSM samples possessed cytotoxicity against CACO-2 and HepG-2 cells, and they could be considered to play a substantial role in pharmaceutical and therapeutic applications.

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“…Moreover, complete risk evaluations must be performed on nanomaterials, which represent a real exposure hazard all during their manufacture or use [63][64][65][66][67][68]. Hence, green nanotechnology is also considered to lower the potential ecological and human health dangers from the manufacturing and use of nanosized materials, and to progress toward the replacement of predominant materials with innovative nanosized materials, which are extremely environmentally friendly [69,70].…”

Section: Clay Nanoparticles Bricks and Mortarmentioning

confidence: 99%

Recent Advancements in the Nanomaterial Application in Concrete and Its Ecological Impact

2021

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At present, nanotechnology is a significant research area in different countries, owing to its immense ability along with its economic impact. Nanotechnology is the scientific study, development, manufacturing, and processing of structures and materials on a nanoscale level. It has tremendous application in different industries such as construction. This study discusses the various progressive uses of nanomaterials in concrete, as well as their related health risks and environmental impacts. Nanomaterials such as nanosilica, nano-TiO2, carbon nanotubes (CNTs), ferric oxides, polycarboxylates, and nanocellulose have the capability to increase the durability of buildings by improving their mechanical and thermal properties. This could cause an indirect reduction in energy usage and total expenses in the concrete industry. However, due to the uncertainties and irregularities in size, shape, and chemical compositions, some nanosized materials might have harmful effects on the environment and human health. Acknowledgement of the possible beneficial impacts and inadvertent dangers of these nanosized materials to the environment will be extremely important when pursuing progress in the upcoming years. This research paper is expected to bring proper attention to the probable effects of construction waste, together with the importance of proper regulations, on the final disposal of the construction waste.

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Greener nanoscience: Piper betel leaf extract mediated synthesis of CaO nanoparticles and evaluation of its antibacterial and anticancer activity

Cited by 19 publications

References 18 publications

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

A Robust and Highly Precise Alternative against the Proliferation of Intestinal Carcinoma and Human Hepatocellular Carcinoma Cells Based on Lanthanum Strontium Manganite Nanoparticles

Recent Advancements in the Nanomaterial Application in Concrete and Its Ecological Impact

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