Green tea supplementation produces better neuroprotective effects than red and black tea in Alzheimer-like rat model

Schimidt, Helen Lidiane; Garcia, Alexandre; Martins, Anelise Afonso; Mello‐Carpes, Pâmela Billig; Carpes, Felipe Pivetta

doi:10.1016/j.foodres.2017.07.026

Cited by 87 publications

(59 citation statements)

References 34 publications

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“…The researchers suggest that EGCG and its derivatives may facilitate the treatment of neurological disorders by inhibiting the formation of Aβ fibrils. Schimidta et al [47] studied the impact of green, red, and black tea supplementation in a rat model of AD. They concluded that green tea was more effective than the other two types, which they attributed to its higher EGCG content.…”

Section: Discussionmentioning

confidence: 99%

Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors

2020

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Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized, among others, by abnormally low levels of the neurotransmitter acetylcholine in the brain. Acetylcholinesterase (AChE) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. Currently, the main method for treatment of AD at a symptomatic stage entails administration of AChE inhibitors to patients diagnosed with the disease. However, it is also possible to take certain steps to treat AD by delivering inhibitors with food. There is a growing body of evidence to suggest that tea (Camellia sinensis) shows numerous beneficial properties, including improving cognitive abilities. This is particularly important in the case of AD patients. The study assessed the impact of brewing conditions on the inhibition of AChE activity observed in tea extracts (black, white, or fruit). Our study revealed that neither temperature nor time of brewing influenced the respective infusions' ability to inhibit the activity of AChE. Anticholinesterase activity was observed in most of the different types of tea that were analyzed, with the highest rate of inhibition (30.46%-48.54%) evidenced in the Biofix Tea Wild Strawberry brand. The results of our research show that tea may be used as a rich source of cholinesterase inhibitors which play a significant role in AD treatment.

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Section: Discussionmentioning

confidence: 99%

Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors

2020

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“…Accumulating evidence demonstrated that Aβ [25][26][27][28][29][30][31][32][33][34][35] is the key fragment of full-length Aβ 1-42 and the acute injection of Aβ [25][26][27][28][29][30][31][32][33][34][35] into rat cerebral ventricle may lead to neurotoxic effects similar to those produced by the Aβ 1-40 ; however, the presence of the Aβ 25-35 fragment in the Ad brains remains to be determined (21,22). Previous studies indicated that bilateral hippocampal injection of Aβ [25][26][27][28][29][30][31][32][33][34][35] may induce an Ad learning and memory impairment model in rats, which has been widely used in Ad research (23,24). Therefore, Aβ [25][26][27][28][29][30][31][32][33][34][...…”

Section: Discussionmentioning

confidence: 99%

CZ2HF mitigates β-amyloid 25-35 fragment-induced learning and memory impairment through inhibition of neuroinflammation and apoptosis in rats

et al. 2018

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cu-zhi-2-hao-fang (cZ2HF), a traditional chinese medicine, has been used clinically for the treatment of amnesia. However, whether cZ2HF is capable of alleviating learning and memory impairment in Alzheimer's disease (Ad) remains to be elucidated. The present study was designed to explore the effect and mechanism of cZ2HF on β-amyloid [25][26][27][28][29][30][31][32][33][34][35] )-induced impairment in the learning and memory of rats. Morris water maze test was used to determine spatial learning and memory ability in Aβ 25-35 -induced Ad rats and hippocampal neuronal damage and apoptosis were observed using hematoxylin and eosin staining, Nissl staining and terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) assays, respectively. The levels of β-amyloid 1-42 (Aβ 1-42 ), pro-inflammatory factors, such as cyclooxygenase-2 (cOX-2), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) and apoptosis-associated genes including B cell leukemia/lymphoma 2 (Bcl-2), Bcl-2-associated X, apoptosis regulator (Bax), pro-caspase-3, inhibitor of κB (IκB-α) degradation and phosphorylated-nuclear factor-κB p65 (p-NF-κB p65) activation were analyzed using western blotting. The findings of the present study revealed that CZ2HF treatment significantly attenuated Aβ 25-35 -induced cognitive impairments in rats. Subsequently, cZ2HF treatment markedly inhibited neuronal damage and deletions. Furthermore, cZ2HF reduced TNF-α, IL-1β, cOX-2 protein expression levels, Bax/Bcl-2 ratio, and reduced Aβ 1-42 and active-caspase-3 levels. In addition, IκB-α degradation and p-NF-κB p65 activation were reduced by cZ2HF. These findings suggested that cZ2HF treatment improved Aβ 25-35 -induced learning and memory impairment and hippocampal neuronal injury, and its underlying mechanism may be due to the inhibition of neuroinflammation and neuronal apoptosis. cZ2HF may be a potential agent for the treatment of Ad. Abbreviations:Ad, Alzheimer's disease; cZ2HF, cu-zhi-2-hao-fang; Aβ 25-35 , β-amyloid 25-35; MWM, Morris water maze; H&E, hematoxylin and eosin; TUNEL, terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling; cOX-2, cyclooxygenase-2; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; NF-κB p65, nuclear factor-κB p65

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“…For instance, tea could protect against kidney injuries induced by a high-fat diet, proline, gentamicin, lead, and ischemia-reperfusion [178][179][180][181][182][183]. In addition, tea has exhibited the neuro-protective effect, in terms of protecting against age-related neuro-degenerative disorders, depression and regulating the circadian clock [184][185][186][187][188][189][190]. Moreover, tea could inhibit gastric ulcer and improve gastrointestinal function [191][192][193][194][195].…”

Section: Other Health Functionsmentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

242

150

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Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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Green tea supplementation produces better neuroprotective effects than red and black tea in Alzheimer-like rat model

Cited by 87 publications

References 34 publications

Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors

Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors

CZ2HF mitigates β-amyloid 25-35 fragment-induced learning and memory impairment through inhibition of neuroinflammation and apoptosis in rats

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

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