Green Tea Protection Against Age-Dependent Ethanol-Induced Oxidative Stress

Łuczaj, Wojciech; Waszkiewicz, Ewa; Skrzydlewska, Elżbieta; Roszkowska-Jakimiec, W

doi:10.1080/15287390490425579

Cited by 35 publications

(21 citation statements)

References 49 publications

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“…Other mechanisms for EtOH-induced hepatic GSH depletion may involve increased efflux of GSH from the liver as observed previously [52,53] or enhanced utilization of GSH for the detoxification of free radicals and oxidants produced as a result of EtOH exposure [17,[54][55][56]. The role of GSH in protection against EtOH-induced oxidative stress is wellestablished [56][57][58] and human studies have suggested that alterations in GSH metabolism in erythrocytes of alcoholics are principally due to this protective function [59].…”

Section: Discussionmentioning

confidence: 97%

Glutathione depletion and recovery after acute ethanol administration in the aging mouse

Vogt

Richie

2007

Biochemical Pharmacology

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Glutathione (GSH) plays an important role in the detoxification of ethanol (EtOH) and acute EtOH administration leads to GSH depletion in the liver and other tissues. Aging is also associated with a progressive decline in GSH levels and impairment in GSH biosynthesis in many tissues. Thus, the present study was designed to examine the effects of aging on EtOH-induced depletion and recovery of GSH in different tissues of the C57Bl/6NNIA mouse. EtOH (2-5 g/kg) or saline was administered i.p. to mice of ages 6 mo (young), 12 mo (mature), and 24 mo (old); and GSH and cyst(e)ine concentrations were measured 0-24 hours thereafter. EtOH administration (5g/kg) depleted hepatic GSH levels >50% by 6 hr in all animals. By 24 hr, levels remained low in both young and old mice, but recovered to baseline levels in mature mice. At 6 hr, the decrease in hepatic GSH was dosedependent up to 3 g/kg EtOH, but not at higher doses. The extent of depletion at the 3 g/kg dose was dependent upon age, with old mice demonstrating significantly lower GSH levels than mature mice (P<0.001). Altogether these results indicate that aging was associated with a greater degree of EtOH and fasting-induced GSH depletion and subsequent impaired recovery in liver. An impaired ability to recover was also observed in young animals. Further studies are required to determine if an inability to recover from GSH depletion by EtOH is associated with enhanced toxicity.

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Section: Discussionmentioning

confidence: 97%

Glutathione depletion and recovery after acute ethanol administration in the aging mouse

Vogt

Richie

2007

Biochemical Pharmacology

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“…However, Kitani et al (2004) report that green tea as the sole source of liquid did not significantly increase life span in mice, compared to controls. However, green tea did protect against ethanol-induced oxidative stress in aged mice, and prevented serum lipids and protein from oxidative damage, produced by ethanol and enhanced by aging (Luczaj et al, 2004). Interestingly, using an aged mouse model of accelerated senescence (SAMP10 mice), Unno et al (2004) demonstrated that green tea catechins, when administered in drinking water, had a protective effect on cognitive dysfunction and suppressed cerebral atrophy in these animals.…”

Section: Agingmentioning

confidence: 96%

Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications

2006

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“…The results have been promising [6][7][8]. In recent years, the importance of antioxidant activities of phytoconstituents has gained attention due to their capacity to act as powerful antioxidants.…”

Section: Introductionmentioning

confidence: 73%

Ethanol-Induced Alterations in Cardiac Enzymes–ameliorative Effect of Thespesia Populnea Leaf Extract

Rajbanshi¹,

Paranjape²,

Appanna

2017

Int J Pharm Pharm Sci

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Objective: This study covers the estimation of changes in cardiac enzymes such as ATPases and antioxidant enzymes following ethanoladministration in rats, and the possible ameliorative effect of leaf extract of the plant Thespesia populnea (TP) on these changes. Methods:Male adult Wistar rats were divided into 10 groups of six rats each. Vehicle controls received 5% gum acacia. Experimental groups received ethanol (20%, 2g/kg); or TP leaf extract (200 mg/kg and 400 mg/kg respectively); or vitamin E (25 mg/kg); or carvedilol (1 mg/kg) per orally every morning for 6 w, individually as well as in combination with ethanol. Following this, changes in the activities of Na + ATPase, Ca 2+ ATPase, Mg 2+ ATPase, and antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) were determined in the heart tissue and compared with those in vehicle control.Results: Ethanol (20%, 2g/kg) treatment caused a reduction from the vehicle control in activities of all the examined enzymes, with minimal reduction in Mg 2+ ATPase activity (29.26%) and maximal reduction in CAT activity (71.05%). With TP leaf extracts of 200 and 400 mg/kg, vitamin E and carvedilol individually, the vehicle controls showed percent changes in enzyme activities ranging from -8.24% for Mg 2+ ATPase activity to+109.39% for Na + ATPase activity caused by carvedilol. When administered along with ethanol, TP leaf extracts, vitamin E and carvedilol reversed the effect of ethanol to various degrees and brought back the enzyme activities to near vehicle control levels. While recovery with 200 mg Thespesia leaf extract was less, ranging from 24.1% for Mg 2+ ATPase activity to 190.91% for CAT activity, 400 mg Thespesia extract effected a greater recovery, with a minimum of 48.19% for Mg 2+ ATPase activity and a maximum of 222.73% for CAT activity, as compared with ethanol-treated rats as controls. These effects could be interpreted in terms of the adverse effects of ethanol on cardiac function and the ameliorative effects, primarily the antioxidant potential, of TP leaf extracts, vitamin E and carvedilol. Conclusion:The restoration of enzyme activities with TP leaf extract may promote recovery of cardiac tissue from oxidative damage. Results from the current study indicate that treatment with TP leaf extract reduces ethanol-induced oxidative stress in rat heart and hence may help prevent cardiac damage.

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Green Tea Protection Against Age-Dependent Ethanol-Induced Oxidative Stress

Cited by 35 publications

References 49 publications

Glutathione depletion and recovery after acute ethanol administration in the aging mouse

Glutathione depletion and recovery after acute ethanol administration in the aging mouse

Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications

Ethanol-Induced Alterations in Cardiac Enzymes–ameliorative Effect of Thespesia Populnea Leaf Extract

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