Green Tea Polyphenols Promote Functional Recovery from Peripheral Nerve Injury in Rats

Chen, Jinhong; Yang, Rongyuan; Li, Honghan; Lao, Jie

doi:10.12659/msm.923806

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Intraperitoneal injection of GTP has also been shown to improve nerve regeneration after end-to-end repair of rat sciatic nerve. Rats who received GTP demonstrated less fibrosis, increased nerve conduction velocity and skeletal muscle wet weight, and increased number and size of myelinated fibers associated with higher expression of NGF, GAP-43 (axonal regeneration marker), Neurofilament (NF)200, and myelin-associated glycoprotein (MAG) in the regenerated nerve compared with vehicle-treated rats [37].…”

Section: Flavanolsmentioning

confidence: 99%

The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration

Muratori

Fregnan

Maurina

et al. 2022

IJMS

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Peripheral nerves are frequently affected by lesions caused by trauma (work accidents, car incidents, combat injuries) and following surgical procedures (for instance cancer resection), resulting in loss of motor and sensory function with lifelong impairments. Irrespective of the intrinsic capability of the peripheral nervous system for regeneration, spontaneous or surgically supported regeneration is often unsatisfactory with the limited functional success of nerve repair. For this reason, many efforts have been made to improve the regeneration process. Beyond innovative microsurgical methods that, in certain cases, are necessary to repair nerve injuries, different nonsurgical treatment approaches and adjunctive therapies have been investigated to enhance nerve regeneration. One possibility could be taking advantage of a healthy diet or lifestyle and their relation with proper body functions. Over the years, scientific evidence has been obtained on the benefits of the intake of polyphenols or polyphenol-rich foods in humans, highlighting the neuroprotective effects of these compounds in many neurodegenerative diseases. In order to improve the available knowledge about the potential beneficial role of polyphenols in the process of peripheral nerve regeneration, this review assessed the biological effects of polyphenol administration in supporting and promoting the regenerative process after peripheral nerve injury.

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Section: Flavanolsmentioning

confidence: 99%

The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration

Muratori

Fregnan

Maurina

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…For rats with severed sciatic nerve, only the epineurium was sutured, and the application of green tea polyphenols could promote the mRNA and protein expressions of NGF, GAP-43, NF200 and MAG in sciatic nerve fibers. The adhesion between the nerve anastomosis and the surrounding tissue is relieved, and the nerve conduction velocity, the development of myelinated nerve fibers and the axonal regeneration are significantly improved, and the nerve regeneration is significantly promoted [51]. Green tea polyphenols and biodegradable poly (ε-caprolactone) (PCL) were made into polymeric implants, which can release green tea polyphenols for a long time, and may play a positive role in the clinical application of green tea polyphenols [52].…”

Section: Neuroprotection and Promotion Of Nerve Regenerationmentioning

confidence: 99%

Polymers containing natural plant phenolic compounds for peripheral nerve injury

Zheng

Qiu

et al. 2022

BAB

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Peripheral nerve injury is a serious and disabling disease prevalent in the world. It caused by trauma is often accompanied with soft tissue injuries, fractures, infections, etc., and can cause permanent damage. The treatment methods of peripheral nerve injury mainly include traditional microsurgical repair, neurotrophic drug treatment, as well as cuttingedge nerve conduit treatment, nerve stimulation, cell therapy, etc. However, more than 30% of patients with peripheral nerve injury still have poor recovery, including partial loss or complete loss of motor and/or sensory function, muscle atrophy，chronic pain and severe disability, among can lead to permanent disease. Phenolic compounds are secondary metabolites which is the most abundant in plants, consisting of an aromatic ring and one or more hydroxyl substituents, the main groups including flavonoids, phenolic acids, tannins, stilbene and lignans. A lot of studies have shown that natural phenolic compounds have various properties, such as antioxidant, anti-infective, anticancer, anti-inflammatory, etc., and have broad applications in the prevention of heart disease, cancer, diabetes, oxidative stress-related diseases, and neuroprotection prospect. This review discusses the potential applications and molecular mechanisms of natural phenolic compounds its polymer derivatives in the treatment of peripheral nerve injury.

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“…As a result, some recent studies have suggested embedding bioactive agents into NCs as a viable strategy to improve their efficacy and further enhance PNR [8][9][10][11][12]. For instance, phytochemicals (e.g., curcumin, ascorbic acid, green tea polyphenols, quercetin, and ursolic acid) have demonstrated their potential to promote PNR following PNI in animal studies [5,[13][14][15]. These compounds demonstrated notable improvements in functional recovery compared to mock conditions through assessments of nerve conduction velocity, nerve compound action potential, axon regeneration, axon remyelination, and sciatic function index.…”

Section: Introductionmentioning

confidence: 99%

Design and Development of a Polymeric-Based Curcumin Nanoparticle for Drug Delivery Enhancement and Potential Incorporation into Nerve Conduits

Giannelli,

Davidson,

Pereira

et al. 2024

Molecules

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Peripheral nerve injuries (PNI) impact millions of individuals in the United States, prompting thousands of nerve repair procedures annually. Nerve conduits (NC) are commonly utilized to treat nerve injuries under 3 cm but larger gaps still pose a challenge for successful peripheral nerve regeneration (PNR) and functional recovery. This is partly attributed to the absence of bioactive agents such as stem cells or growth factors in FDA-approved conduits due to safety, harvesting, and reproducibility concerns. Therefore, curcumin, a bioactive phytochemical, has emerged as a promising alternative bioactive agent due to its ability to enhance PNR and overcome said challenges. However, its hydrophobicity and rapid degradation in aqueous solutions are considerable limitations. In this work, a nanoscale delivery platform with tannic acid (TA) and polyvinylpyrrolidone (PVP) was developed to encapsulate curcumin for increased colloidal and chemical stability. The curcumin nanoparticles (CurNPs) demonstrate significantly improved stability in water, reduced degradation rates, and controlled release kinetics when compared to free curcumin. Further, cell studies show that the CurNP is biocompatible when introduced to neuronal cells (SH-SY5Y), rat Schwann cells (RSC-S16), and murine macrophages (J774 A.1) at 5 μM, 5 μM, and 10 μM of curcumin, respectively. As a result of these improved physicochemical properties, confocal fluorescence microscopy revealed superior delivery of curcumin into these cells when in the form of CurNPs compared to its free form. A hydrogen peroxide-based oxidative stress study also demonstrated the CurNP’s potential to protect J774 A.1 cells against excessive oxidative stress. Overall, this study provides evidence for the suitability of CurNPs to be used as a bioactive agent in NC applications.

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Green Tea Polyphenols Promote Functional Recovery from Peripheral Nerve Injury in Rats

Cited by 5 publications

References 37 publications

The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration

The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration

Polymers containing natural plant phenolic compounds for peripheral nerve injury

Design and Development of a Polymeric-Based Curcumin Nanoparticle for Drug Delivery Enhancement and Potential Incorporation into Nerve Conduits

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