Green tea polyphenols decrease weight gain, ameliorate alteration of gut microbiota, and mitigate intestinal inflammation in canines with high-fat-diet-induced obesity

Li, Yu; Rahman, Sajid Ur; Huang, Yingying; Zhang, Yafei; Ming, Pengfei; Zhu, Lei; Chu, Xiaoyan; Li, Jinchun; Shi, Feng; Wang, Xichun; Wu, Jiawei

doi:10.1016/j.jnutbio.2019.108324

Cited by 91 publications

(64 citation statements)

References 54 publications

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“…In addition, green tea catechins have anti-inflammatory properties 33,34 , which help to mitigate against oxidative tissue injury 34 . Subsequent changes in the gut microbiota and reduced intestinal inflammation may then be related to the anti-inflammatory properties of green tea and green tea polyphenols 35 . Although there are no studies describing the relationship between green tea consumption and the prevalence of pks + E. coli, one study has described the effects of green tea consumption on the gut microbiome.…”

Section: Discussionmentioning

confidence: 99%

Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults

Watanabe

Murakami

Ohno

et al. 2020

Sci Rep

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The relative contribution of diet to colorectal cancer (CRC) incidence is higher than that for other cancers. Animal models have revealed that Escherichia coli containing polyketide synthase (pks+E. coli) in the gut participates in CRC development. The purpose of this cross-sectional study was to examine the relationship between dietary intake and the prevalence of pks+E. coli isolated from the microbiota in faecal samples of 223 healthy Japanese individuals. Dietary intake was assessed using a previously validated brief-type self-administered diet history questionnaire. The prevalence of pks+E. coli was evaluated using faecal samples collected from participants and specific primers that detected pks+E. coli. The prevalence of pks+E. coli was 26.9%. After adjusting for baseline confounders, the prevalence of pks+E. coli was negatively associated with the intake of green tea (odds ratio [OR], 0.59 [95% confidence interval (CI) 0.30–0.88] per 100 g/1,000 kcal increment) and manganese (OR, 0.43 [95% CI 0.22–0.85] per 1 mg/1,000 kcal increment) and was positively associated with male sex (OR, 2.27 [95% CI 1.05–4.91]). While futher studies are needed to validate these findings, these results provide insight into potential dietary interventions for the prevention of CRC.

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Section: Discussionmentioning

confidence: 99%

Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults

Watanabe

Murakami

Ohno

et al. 2020

Sci Rep

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“…IL-6 and IL-1β mRNA expression also significantly decreased (p < 0.01) in both TPs groups compared to the HFD group. In our previous study, we also demonstrated that TNF-α, IL-6 and IL-1β mRNA gene expression were significantly decreased by green tea polyphenols in the intestinal epithelial layer of canines [18]. These results suggested the protective effects of TPs on immunological liver inflammation act by inhibiting inflammatory cytokine expression.…”

Section: Discussionmentioning

confidence: 61%

“…Green tea and its major polyphenolic components (EGCG (−) epigallocatechin gallate; EGC (−) epigallocatechin; ECG (−)-epicatechin gallate; EC (−)-epicatechin) catechins ( Fig. 1) possess many potential health benefits including anti-inflammatory, antioxidant, anti-carcinogenic, and cardio-protective effects [16][17][18][19]. Many studies highlight the beneficial effects of TPs on increasing energy expenditure and decreasing fat mass, as well as helping in weight maintenance after weight control programs [20].…”

Section: Introductionmentioning

confidence: 99%

Tea polyphenols attenuate liver inflammation by modulating obesity-related genes and down-regulating COX-2 and iNOS expression in high fat-fed dogs

et al. 2020

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Background: Tea polyphenols (TPs) attenuate obesity related liver inflammation; however, the anti-obesity effects and anti-inflammatory mechanisms are not clearly understood. This study aimed to determine whether the antiobesity and anti-inflammatory TPs mechanisms associated with cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression levels, and obesity-related gene response in dogs. Results: Dogs fed TPs displayed significantly decreased (p < 0.01) mRNA expression of tumor necrosis factor-α (TNFα), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) compared to dogs that consumed high-fat diet (HFD) alone. TPs significantly (p < 0.01) inhibited COX-2 and iNOS expression level, and decreased liver fat content and degeneration. Conclusion: These results suggested that TPs act as a therapeutic agent for obesity, liver inflammation, and fat degeneration via COX-2 and iNOS inhibition, with TNF-α, IL-1β, and IL-6 involvement.

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“…Phycicoccus and Collinsella also showed significantly-higher abundance in tilapia fed β-glucan. These two groups of microorganisms showed higher abundance in the intestine of Eriocheir sinensis and canines when fed diets with L-tryptophan and green tea polyphenols, respectively [69,70]. Compared to tilapia in brackish water fed a basal diet, 0.4% β-glucan in the diet significantly increased the richness of Streptomyces in the intestine.…”

Section: Discussionmentioning

confidence: 95%

Recovery from Hypersaline-Stress-Induced Immunity Damage and Intestinal-Microbiota Changes through Dietary β-glucan Supplementation in Nile tilapia (Oreochromis niloticus)

Suo

Wang

et al. 2020

Animals

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Long-term exposure to hyperosmotic environments can induce severe immune damage and increase risk in tilapia breeding. As an effective immunoregulator, β-glucan has attracted extensive attention in nutritional research and given rise to high expectations of improving health status and alleviating organismal damage in tilapia, Oreochromis niloticus, in brackish water. In this study, an 8-week cultivation experiment was conducted on tilapia fed a basal diet or diets with β-glucan supplementation in freshwater (control) and brackish water. Growth performance, hematological aspects, immune cytokine expression, and the intestinal microbiota of tilapia were analyzed. The results indicated that supplementation with β-glucan significantly reduced the enlarged spleen of tilapia resulting from hypersaline stress. Tilapia fed β-glucan showed significantly-greater decreases in the red blood cell count, hematocrit, red cell distribution width, platelet count, and plateletcrit than those fed the basal diet. β-glucan significantly decreased the high expression of immune-related genes in the spleen induced by hyperosmotic stress. In the intestine, the high migration inhibitory factor-2 (MIF-2) and IL-1β gene expression induced by hypersaline stress was significantly reduced. β-glucan supplementation also significantly increased the abundance of beneficial microbiota such as Lactobacillus, Phycicoccus, and Rikenellaceae. Therefore, dietary β-glucan supplementation can significantly reduce spleen enlargement and improve immune function in tilapia in brackish water. β-glucan intake can also optimize the intestinal microbiota of tilapia in brackish water and improve fish health.

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Green tea polyphenols decrease weight gain, ameliorate alteration of gut microbiota, and mitigate intestinal inflammation in canines with high-fat-diet-induced obesity

Cited by 91 publications

References 54 publications

Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults

Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults

Tea polyphenols attenuate liver inflammation by modulating obesity-related genes and down-regulating COX-2 and iNOS expression in high fat-fed dogs

Recovery from Hypersaline-Stress-Induced Immunity Damage and Intestinal-Microbiota Changes through Dietary β-glucan Supplementation in Nile tilapia (Oreochromis niloticus)

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