J. Neurosci. Res. volume 87, issue 2, P567-575 2009 DOI: 10.1002/jnr.21847 View full text
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Jong-Wan Park, Young-Ho Jang, Jin-Mo Kim, Hyung Lee, Weon-Kyun Park, Man-Bin Lim, Yeun-Kyung Chu, Eng H. Lo, Seong-Ryong Lee

Abstract: Previous studies have demonstrated that (-)-epigallocatechin gallate (EGCG), a green tea polyphenol, protects against ischemia and reperfusion-induced injury in many organ systems. Here, we test the hypothesis that part of EGCG's neuroprotective effects may involve a modulation of matrix metalloproteinases (MMPs) after cerebral ischemia. C57BL/6 mice were subjected to 20 min of transient global cerebral ischemia. EGCG (50 mg/kg) or vehicle (saline) was administered i.p. immediately after ischemia. Brains were …

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