Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice

Huang, Jinbao; Feng, Simin; Liu, Anna; Dai, Zhuqing; Wang, Hong; Reuhl, Kenneth R.; Lu, Wenyun; Yang, Chung S.

doi:10.1002/mnfr.201700696

Cited by 91 publications

(75 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, CD36 KO mice are protected from diet-induced weight gain (58). Moreover, it has been shown that EGCG increases fecal lipid content (59)(60)(61). Thus, it is likely that EGCG reduces body fat by decreasing fatty acid uptake and increasing excretion.…”

Section: Discussionmentioning

confidence: 99%

Obesity treatment by epigallocatechin‐3‐gallate−regulated bile acid signaling and its enriched Akkermansia muciniphila

et al. 2018

View full text Add to dashboard Cite

Dysregulated bile acid (BA) synthesis is accompanied by dysbiosis, leading to compromised metabolism. This study analyzes the effect of epigallocatechin-3-gallate (EGCG) on diet-induced obesity through regulation of BA signaling and gut microbiota. The data revealed that EGCG effectively reduced diet-increased obesity, visceral fat, and insulin resistance. Gene profiling data showed that EGCG had a significant impact on regulating genes implicated in fatty acid uptake, adipogenesis, and metabolism in the adipose tissue. In addition, metabolomics analysis revealed that EGCG altered the lipid and sugar metabolic pathways. In the intestine, EGCG reduced the FXR agonist chenodeoxycholic acid, as well as the FXR-regulated pathway, suggesting intestinal FXR deactivation. However, in the liver, EGCG increased the concentration of FXR and TGR-5 agonists and their regulated signaling. Furthermore, our data suggested that EGCG activated Takeda G protein receptor (TGR)-5 based on increased GLP-1 release and elevated serum PYY level. EGCG and antibiotics had distinct antibacterial effects. They also differentially altered body weight and BA composition. EGCG, but not antibiotics, increased Verrucomicrobiaceae, under which EGCG promoted intestinal bloom of Akkermansia muciniphila. Excitingly, A. muciniphila was as effective as EGCG in treating diet-induced obesity. Together, EGCG shifts gut microbiota and regulates BA signaling thereby having a metabolic beneficial effect.-Sheng, L., Jena, P. K., Liu, H.-X., Hu, Y., Nagar, N., Bronner, D. N., Settles, M. L., Bäumler, A. J. Wan, Y.-J. Y. Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila.

show abstract

Section: Discussionmentioning

confidence: 99%

Obesity treatment by epigallocatechin‐3‐gallate−regulated bile acid signaling and its enriched Akkermansia muciniphila

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It is reported that lipidomic analysis of serum and liver could facilitate the understanding of the mechanism of various human diseases caused by hyperlipemia . Previous studies showed that the higher neutral glycerolipid and lower sphingolipids in liver in hyperlipidemia mice caused by HFD .…”

Section: Discussionmentioning

confidence: 99%

Long Term Egg Yolk Consumption Alters Lipid Metabolism and Attenuates Hyperlipidemia in Mice Fed a High‐Fat Diet Based on Lipidomics Analysis

Wang

Ahn

et al. 2019

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

Studies on the association between egg yolk (EY) consumption and obesity are limited and the involved mechanism still needs to be further explored. In this study, the effects of EY consumption under normal and high fat diets on mice based on lipidomics approach is compared. A total of 893 and 925 individual lipid species are determined in serum and liver, respectively. The results reveal that EY can alleviate the hyperlipidemia in HFD‐induced obese mice by increasing serum high‐density lipoprotein cholesterol (HDL‐C) and neutral glycerolipid, hepatic fatty acids (FAs), and the size of adipose tissue cells. OPLS‐DA and S‐plots show that 29 lipid biomarkers in serum, mainly including phosphatidylcholine (PC), triglyceride (TG), and phosphatidylinositol (PI), and 44 lipid biomarkers in liver including TG, lysophosphatidylcholine (lysoPC), and lysophosphatidylethanolamine (lysoPE) are related to obesity caused by HFD. In addition, the regulation of EY on lipid disorders is mainly related to the decreases in serum TG and PC, and hepatic fatty acids (FAs), TG and diacylglycerol (DG), which is closely associated with glycerophospholipid metabolism. These findings suggest that long‐term treatment of EY consumption may not increase NAFLD risk factors in normal diet‐fed mice, further improving the hyperlipidemia in HFD‐induced mice. Practical Applications: This study investigates the overall effects of EY on normal and high‐fat diet by lipidomic analysis. It is concluded that the intake of EY can improve the hyperlipidemia in HFD‐induced obese mice by improving glycerophospholipid metabolism. These results facilitate to comprehensively evaluate the nutrition of EY and help elucidate the favorable effect of eggs. The flow chart of the egg yolk nutritional evaluation based on 100‐d mice experiment. The lipid profiles in serum and liver are further investigated using UPLC‐MS/MS method to elucidate its favorable effect on lipid metabolism.

show abstract

“…Compared with control, weight gain, insulin resistance, serum cholesterol, and severity of fatty liver of treated mice were reduced after 17 weeks of treatment. Tea epigallocatechin gallate attenuated most effects of high‐fat diet on lipid species, by preventing most changes in free fatty acids, DAG, TAG, PC, PE, SM, and CE (Huang et al., 2018).…”

Section: Application Of Ms‐based Lipidomics In Nutrition and Human Hementioning

confidence: 99%

Mass spectrometry‐based lipidomics in food science and nutritional health: A comprehensive review

Sun

Wang

Cong

et al. 2020

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

With the advance in science and technology as well as the improvement of living standards, the function of food is no longer just to meet the needs of survival. Food science and its associated nutritional health issues have been increasingly debated. Lipids, as complex metabolites, play a key role both in food and human health. Taking advantages of mass spectrometry (MS) by combining its high sensitivity and accuracy with extensive selective determination of all lipid classes, MS‐based lipidomics has been employed to resolve the conundrum of addressing both qualitative and quantitative aspects of high‐abundance and low‐abundance lipids in complex food matrices. In this review, we systematically summarize current applications of MS‐based lipidomics in food field. First, common MS‐based lipidomics procedures are described. Second, the applications of MS‐based lipidomics in food science, including lipid composition characterization, adulteration, traceability, and other issues, are discussed. Third, the application of MS‐based lipidomics for nutritional health covering the influence of food on health and disease is introduced. Finally, future research trends and challenges are proposed. MS‐based lipidomics plays an important role in the field of food science, promoting continuous development of food science and integration of food knowledge with other disciplines. New methods of MS‐based lipidomics have been developed to improve accuracy and sensitivity of lipid analysis in food samples. These developments offer the possibility to fully characterize lipids in food samples, identify novel functional lipids, and better understand the role of food in promoting healt.

show abstract

Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice

Abstract: EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreases the absorption of lipids. These actions contribute to the alleviation of metabolic abnormalities and fatty liver disease caused by the high-fat diet.

Cited by 91 publications

References 38 publications

Obesity treatment by epigallocatechin‐3‐gallate−regulated bile acid signaling and its enriched Akkermansia muciniphila

Obesity treatment by epigallocatechin‐3‐gallate−regulated bile acid signaling and its enriched Akkermansia muciniphila

Long Term Egg Yolk Consumption Alters Lipid Metabolism and Attenuates Hyperlipidemia in Mice Fed a High‐Fat Diet Based on Lipidomics Analysis

Mass spectrometry‐based lipidomics in food science and nutritional health: A comprehensive review

Contact Info

Product

Resources

About