Green tea leaf extract improves lipid and glucose homeostasis in a fructose-fed insulin-resistant hamster model

Li, Rachel; Douglas, Teresa D.; Maiyoh, Geoffrey K.; Adeli, Khosrow; Theriault, André

doi:10.1016/j.jep.2005.08.045

Cited by 70 publications

(57 citation statements)

References 31 publications

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“…1). These results suggest that the hypolipidemic effect of BBL can be attributed to a reduction of FAS activity and 31) In addition, previous reports have indicated that BBL contains a variety of phenolic compounds, such as chlorogenic acid, quercetin, caffeic acid, and procyanidins, and has oxygen radical absorbance capacity and antileukaemic activity. 32-34) Therefore, it is likely that tannin, contained in BBL, partly contributes to preventing the development of obesity-induced diseases in OLETF rats.…”

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confidence: 58%

“…29,30) Li et al also showed that green tea leaf extract enhanced hepatic expression of lipolytic transcriptional factor PPAR-alpha and improved lipid homeostasis in a fructose-fed insulin-resistant hamster model. 31) In addition, previous reports have indicated that BBL contains a variety of phenolic compounds, such as chlorogenic acid, quercetin, caffeic acid, and procyanidins, and has oxygen radical absorbance capacity and antileukaemic activity. [32][33][34] Therefore, it is likely that tannin, contained in BBL, partly contributes to preventing the development of obesity-induced diseases in OLETF rats.…”

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confidence: 99%

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Effect ofVaccinium ashei readeLeaves on Lipid Metabolism in Otsuka Long-Evans Tokushima Fatty Rats

Nagao

Higa

Shirouchi

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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The effects of blueberry leaf (BBL) on lipid metabolism were studied in obese rats. Feeding of BBL lowered levels of serum lipids and C-reactive protein and alleviated hepatic triglyceride accumulation in the rats. The hypolipidemic effect might be attributable to a reduction of lipogenesis and enhancement of lipolysis in the liver. These results suggest the use of blueberry leaf as a dietary hypolipidemic component.Key words: Vaccinium ashei reade; blueberry leaf; lipid metabolism; Otsuka Long-Evans Tokushima Fatty ratLifestyle-related diseases, such as hyperlipidemia, arteriosclerosis, diabetes mellitus, and hypertension, are widespread and increasingly prevalent diseases in industrialized countries, and they contribute to increases in cardiovascular morbidity and mortality. 1,2) Accompanied by rapid increases in the numbers of elderly people, this is important not only medically but also socioeconomically. Although the pathogenesis of lifestyle-related diseases is complicated and the precise mechanisms have not yet been elucidated, obesity has emerged as a major cardiovascular risk factor according to epidemiologic studies. [3][4][5] Obesity is defined as an increased mass of adipose tissue, and its prevalence and severity are markedly increasing in westernized countries. Otsuka Long-Evans Tokushima Fatty (OLETF) rats develop a syndrome with multiple metabolic and hormonal disorders that shares many features with human obesity. 6-9) OLETF rats have hyperphagia because they lack receptors for cholecystokinin, and become obese, developing hyperlipidemia, fatty liver, and type-2 diabetes. In this study, we examined effects of blueberry leaf (BBL) on lipid metabolism in obese OLETF rats.Vaccinium ashei reade (blueberry) belongs to the Ericaceae plant group, and infusions of its leaf are used as a folk medicine treatment for lifestyle-related diseases in Europe. 10,11) Martineau et al. demonstrated anti-diabetic properties of the Canadian lowbush blueberry in vitro. 11) Recently, we reported that blueberry leaf revealed strong inhibitory effects on angiotensinconverting enzyme activity in vitro, and that feeding of blueberry leaf suppressed the development of essential hypertension in spontaneously hypertensive rats in vivo. 12) The effects of blueberry leaf on lipid metabolism, however, have not been fully evaluated.To determine the physiological function of BBL, we evaluated the effect of BBL feeding on hepatic enzyme activities in relation to lipid metabolism in obese OLETF rats.Four-week-old male OLETF rats were provided by the Tokusima Research Institute (Otsuka Pharmaceutical, Tokushima, Japan). The rats were housed individually in metal cages in a temperature-controlled room (24 C) under a 12-h light/dark cycle. After a 1-week adaptation period on a powder chow diet (CE-2, Clea Japan, Tokyo), they were assigned to three groups (six rats each), each fed one of three diets: (i) a semisynthetic diet containing (in weight %) casein, 20; corn oil, 7; cornstarch, 15; vitamin mixture (AIN-76Ô), 1; mineral mixture ...

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Effect ofVaccinium ashei readeLeaves on Lipid Metabolism in Otsuka Long-Evans Tokushima Fatty Rats

Nagao

Higa

Shirouchi

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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“…Tea is an infusion of the leaves of the Camellia sinensis plant. Epigallocatechin gallate (EGCG) (Fig.1), the major bioactive constituent of C.sinensis has been reported to exhibit many pharmacological effects, including anti-cancer, anti-hyperlipedemic and anti-hyperglycemic activities against a broad spectrum of research [Li et al 2006; Singh et al 2011]. EGCG has been reported to possess strong antioxidant properties (Zhong & Shahidi 2011).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of epigallocatechin gallate on sodium fluoride induced oxidative stress mediated metabolism in rat

Pandiyan

Prabu

2014

International Journal of Pharmacology and Toxicology

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Background: The present study was designed to examine the ant hyperglycemic and antihyperlipidemic effect of Epigallocatechin gallate (EGCG) on fluoride induced oxidative changes in the metabolisms of rats. Methods: The control group received the vehicles only. EGCG alone treated group received the EGCG orally at a dose of 40mg/kg in 10% tween 80 for 4 weeks. The Fl treated group received NaF (25 mg/kg) orally in saline for 4weeks. EGCG + Fl treated group received the EGCG at a dose of 40mg/kg/bw along with NaF. Results: The levels of serum SGOT, SGPT, ALP, ACP and plasma glucose, G6PD, cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density lipoprotein were significantly increased in fluoride intoxicated rats. Furthermore, a significant increase HMG CoA with decreased glycogen, hexokinase, total protein, albumins, high density lipoprotein, lipoprotein lipase, and lecithin cholesterol acyl transferase was observed in fluoride treated rats with altered histological changes. Pre-oral administration of EGCG at a dose of 40 mg/kg bw to fluoride intoxicated rats for a period of 28 days resulted in a significant reduction in the cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density lipoprotein, and elevation of high density lipoprotein with hexokinase. Moreover, lipoprotein lipase, lecithin cholesterol acyl transferase, total protein, and albumins were also increased with decreased serum markers and HMG CoA after EGCG treatment. The histological findings of liver also significantly improved with EGCG pretreatment. Conclusions: These results indicate that the natural dietary antioxidant EGCG showed significant protective effect against Fl-induced oxidative stress mediated metabolic alternations in rats. This may be due to its antihyperlipidemic and ant hyperglycemic property; it will provide an accessible and cheap traditional medicine source for treatment of Fl mediated environmental and occupational ailments.

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“…This was also the case in the previous study of Zeyuan et al, (1998), who reported that green and black tea can decrease blood glucose level of aged rats. Moreover, Li et al, (2006) indicated that tea has been credited with controlling blood glucose levels. It seems worthwhile to suggest that either green tea or black tea may affect glucose metabolism in untreated rats or even in GalN-treated ones.…”

Section: Discussionmentioning

confidence: 99%

Removal of the Bad Effects of D-Galactosamine on Blood Lipids of Male Wistar Rats By Black and Green Tea Consumption

Al‐Seeni¹,

Banjabi²,

Mohamed³

2017

IOSRJPBS

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Green tea leaf extract improves lipid and glucose homeostasis in a fructose-fed insulin-resistant hamster model

Cited by 70 publications

References 31 publications

Effect ofVaccinium ashei readeLeaves on Lipid Metabolism in Otsuka Long-Evans Tokushima Fatty Rats

Effect ofVaccinium ashei readeLeaves on Lipid Metabolism in Otsuka Long-Evans Tokushima Fatty Rats

Ameliorative effect of epigallocatechin gallate on sodium fluoride induced oxidative stress mediated metabolism in rat

Removal of the Bad Effects of D-Galactosamine on Blood Lipids of Male Wistar Rats By Black and Green Tea Consumption

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