Green tea infusion prevents diabetic nephropathy aggravation in recent-onset type 1 diabetes regardless of glycemic control

Ladeira, Luiz Carlos Maia; Santos, Eliziária Cardoso dos; Santos, Talita Amorim; Silva, Janaína; Lima, Graziela Domingues de Almeida; Machado‐Neves, Mariana; Silva, Renê Chagas da; Freitas, Mariella Bontempo; Maldonado, Izabel Regina dos Santos Costa

doi:10.1016/j.jep.2021.114032

Cited by 16 publications

(8 citation statements)

References 71 publications

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“…The normality was analyzed using the Shapiro–Wilk test. Subsequently, the results were submitted to two separate Student's t -test according to previous studies (Souza et al, 2019; Ladeira et al, 2021). The first analysis evaluated the effectiveness of type 1 diabetes induction comparing healthy animals (negative controls) with STZ-induced diabetic animals (diabetes control).…”

Section: Methodsmentioning

confidence: 99%

Green Tea Infusion Ameliorates Histological Damages in Testis and Epididymis of Diabetic Rats

et al. 2021

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Green tea is a popular drink used for therapeutic purposes to mitigate the consequences of diabetes. In this study, we aimed at evaluating the potential of green tea infusion to ameliorate structural and enzymatic damages caused by hyperglycemia in the testis and epididymis of Wistar rats. For that, nondiabetic and streptozotocin-induced diabetic rats (negative control and diabetes control, respectively) received 0.6 mL of water by gavage. Another set of diabetic animals received 100 mg/kg of green tea infusion diluted in 0.6 mL of water/gavage (diabetes + green tea) daily. After 42 days of treatment, the testes and epididymides were removed and processed for histopathological analysis, micromineral determination, and enzymatic assays. The results showed that treatment with green tea infusion preserved the testicular and epididymal histoarchitecture, improving the seminiferous epithelium and the sperm production previously affected by diabetes. Treatment with green tea reduced tissue damages caused by this metabolic condition. Given the severity of hyperglycemia, there was no efficacy of the green tea infusion in maintaining the testosterone levels, antioxidant enzyme activity, and microminerals content. Thus, our findings indicate a protective effect of this infusion on histological parameters, with possible use as a complementary therapy for diabetes.

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Section: Methodsmentioning

confidence: 99%

Green Tea Infusion Ameliorates Histological Damages in Testis and Epididymis of Diabetic Rats

et al. 2021

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“…A large population is impacted because DN affects over 1/2 of all diabetic patients during their lifetime and diabetes could be a global epidemic. Due to the complexity of the disease, existing methods of diagnosis and therapy are unable to forestall disease progression or offer a reliable cure [ 22 ]. Today, most renal physiology is regulated by inflammatory chemicals, which makes DN a signal of inflammation.…”

Section: Reviewmentioning

confidence: 99%

A Narrative Review of New Treatment Options for Diabetic Nephropathy

Pillai¹,

Fulmali²

2023

Cureus

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Diabetic nephropathy (DN) is a type of nephropathy that is caused by a diabetic condition. Diabetic nephropathy is seen in type 1 and type 2 diabetes. End-stage renal disorders are brought on by DN. Diabetic nephropathy is thought to be linked to metabolic changes in the body. Proteinuria and glomerular filtration rate are the two most crucial diagnostic and prognosis measures for diabetic kidney disease (DKD), yet both have significant disadvantages. Novel biomarkers are thus increasingly required to improve risk factors and detect disease at an early stage. Controlling blood glucose and vital sign like body temperature and blood pressure, reducing cholesterol levels, and blocking the renin-angiotensin system are the standard treatments for diabetic patients. On the other hand, if used too late within the course of the disease, these therapeutic techniques can only provide partial relief from nephropathy.The complicated pathophysiology of the diabetic kidney, which experiences a variety of severe structural, metabolic, and functional alterations, represents one of the most important obstacles to the event of effective therapeutics for DN. Despite these issues, new diabetes models have identified promising treatment targets by identifying the mechanisms that control important functions of podocytes and glomerular endothelial cells. It has been shown in the vast majority of trials that renin-angiotensin system inhibitors combined with integrative therapies work well for DN. Combining sodium-glucose cotransporter-2 inhibitors and renin-angiotensin-aldosterone system blockers is a novel way to slow down the course of DKD by lowering inflammatory and fibrotic indicators brought on by hyperglycemia, which is more effective than using either medicine alone. Aldosterone receptor inhibitors and advanced glycation end-product inhibitors are two recently produced medications that may be used successfully to treat DN.

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“…The components of green tea can interact with proteins participating in cell signaling pathways that regulate energy metabolism, including glucose and glycogen synthesis, glucose reabsorption, hypoxia management (hypoglycemiant capacity), and cell death by apoptosis [ 117 , 118 ]. Such interaction reduces the accumulation of glycogen in the kidney’s proximal tubular cells in diabetes, as well as DNA damage [ 124 ]. A double-blind experiment concerning the treatment of diabetic patients with green tea polyphenols revealed that catechins could reduce podocyte apoptosis and improve kidney function by reducing microalbuminuria [ 125 ].…”

Section: Attenuation Of Secondary Mitochondrial Diseases By Catechinsmentioning

confidence: 99%

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

Chen

Zhang

Lin

et al. 2022

IJMS

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Mitochondria are the main sites for oxidative phosphorylation and synthesis of adenosine triphosphate in cells, and are known as cellular power factories. The phrase “secondary mitochondrial diseases” essentially refers to any abnormal mitochondrial function other than primary mitochondrial diseases, i.e., the process caused by the genes encoding the electron transport chain (ETC) proteins directly or impacting the production of the machinery needed for ETC. Mitochondrial diseases can cause adenosine triphosphate (ATP) synthesis disorder, an increase in oxygen free radicals, and intracellular redox imbalance. It can also induce apoptosis and, eventually, multi-system damage, which leads to neurodegenerative disease. The catechin compounds rich in tea have attracted much attention due to their effective antioxidant activity. Catechins, especially acetylated catechins such as epicatechin gallate (ECG) and epigallocatechin gallate (EGCG), are able to protect mitochondria from reactive oxygen species. This review focuses on the role of catechins in regulating cell homeostasis, in which catechins act as a free radical scavenger and metal ion chelator, their protective mechanism on mitochondria, and the protective effect of catechins on mitochondrial deoxyribonucleic acid (DNA). This review highlights catechins and their effects on mitochondrial functional metabolic networks: regulating mitochondrial function and biogenesis, improving insulin resistance, regulating intracellular calcium homeostasis, and regulating epigenetic processes. Finally, the indirect beneficial effects of catechins on mitochondrial diseases are also illustrated by the warburg and the apoptosis effect. Some possible mechanisms are shown graphically. In addition, the bioavailability of catechins and peracetylated-catechins, free radical scavenging activity, mitochondrial activation ability of the high-molecular-weight polyphenol, and the mitochondrial activation factor were also discussed.

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Green tea infusion prevents diabetic nephropathy aggravation in recent-onset type 1 diabetes regardless of glycemic control

Abstract: Green tea infusion prevents diabetic nephropathy's aggravation in recent-onset type 1 diabetes regardless of glycemic control

Cited by 16 publications

References 71 publications

Green Tea Infusion Ameliorates Histological Damages in Testis and Epididymis of Diabetic Rats

Green Tea Infusion Ameliorates Histological Damages in Testis and Epididymis of Diabetic Rats

A Narrative Review of New Treatment Options for Diabetic Nephropathy

A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases

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