Green tea extract prevents the development of nonalcoholic liver steatosis in rats fed a high-fat diet

Non-alcoholic fatty liver disease (NAFLD) and obesity are serious public health problems. Green tea is widely consumed in the world and different green teas could possess different bioactivities. In this study, the effects of 10 selected green teas on obesity and NAFLD were evaluated and compared. The mice fed with a high-fat diet were intervened with green tea extract (200 mg/kg body weight) for 15 weeks. Most of these teas were first evaluated for their effects on obesity and NAFLD. The results showed that Selenium-Enriched Chaoqing Green Tea and Jieyang Chaoqing Tea showed the most prominent inhibition of obesity and body weight gains of mice in these two tea intervention groups and model groups were 5.3, 5.5, and 13.7 g, respectively. In addition, Jieyang Chaoqing Tea, Taiping Houkui Tea, and Selenium-Enriched Chaoqing Green Tea exerted the most notable effect on NAFLD, which was attributed to decreasing body weight, and lipid content and ameliorating oxidative stress. Furthermore, 13 phytochemicals were determined in these teas by high-performance liquid chromatography and the correlation analysis found that epigallocatechin gallate, gallocatechin, and epigallocatechin might contribute to the decrease of hepatic weight, while epicatechin might reduce oxidative stress. In general, several green teas could prevent the development of obesity and NAFLD and could be developed into functional foods. This study was also helpful for the public to select appropriate tea to prevent obesity and NAFLD.

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“…Selenium-Enriched Chaoqing Green Tea (GT8). The results were consistent with previous studies (16,17,20).…”

Section: Histopathological Evaluation Of Liversupporting

confidence: 94%

“…Green tea extract has been used to treat antiobesity (11). On the other hand, growing studies showed the effect of green tea on the prevention and management of NAFLD (16)(17)(18). The hepatoprotective and antiobesity effects of green tea are mainly attributed to its rich bioactive compounds, such as polyphenols.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

Zhou

Mao

et al. 2022

Front. Nutr.

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“…However, relatively high doses of GTE, which did not reflect the amounts of green tea consumed by humans through diet, was used in these animal studies. Karolczak et al (2019) found that GTE supplementation reflecting habitual consumption of 5 -8 cups of this beverage per day successfully reduced the amount of hepatic fat in rats fed with HFD. In the present work, we used tea drink, a common method of tea consumption, to investigate the action of green tea on HFD-induced NAFLD.…”

Section: Discussionmentioning

confidence: 88%

Green tea and selenium-enriched green tea ameliorates non-alcoholic fatty liver disease through peripheral 5-hydroxytryptamine signals in high-fat diet-fed mice

Zhang¹,

Xu²,

Du³

et al. 2021

IFRJ

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Green tea and selenium (Se) improve non-alcoholic fatty liver disease (NAFLD). However, studies on the effect of green tea and Se-enriched green tea on NAFLD are limited. C57BL/6 mice were divided into high-fat diet (HFD), HFD+regular green tea (T), and HFD+Se-enriched green tea (SeT) groups after 12 weeks of feeding with HFD. HFD feeding was continued, and the mice in the HFD+T and HFD+SeT groups drank corresponding tea solution for another 12 weeks. The control (CON) group was given normal diet. At the end of the experiment, serum, liver, fat, and intestinal tract were collected. Results showed that both tea interventions decreased body and fat weight. Histological analysis showed that both tea interventions alleviated steatosis, which is supported by the changes in lipid profiles and lipogenic pathways. Tea interventions significantly increased superoxide dismutase, glutathione peroxidase, and catalase levels; and decreased TNF-α, IL-1β, IL-6, and malondialdehyde contents. HFD significantly increased total bile acid in the intestinal contents and liver, duodenal 5-hydroxytryptamine (5-HT) level and tryptophan hydroxylase gene expression, and hepatic 5-HT, 5-HT receptor 2A, monoamine oxidase-A (MAO-A), and H2O2; all of them reversed by the tea interventions. Furthermore, the improved oxidative stress, inflammatory response, duodenal 5-HT, and hepatic MAO-A were more pronounced in the HFD+SeT group than in the HFD+T group. Our findings revealed that green tea ameliorates NAFLD through peripheral 5-HT signals in HFD fed mice.

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“…46 Karolczak et al studied whether GTE at a dose of habitual green tea beverages could prevent NAFLD in high-fat diet (HFD) rats, indicating the hepatoprotective potential of GTE in preventing dietinduced hepatic steatosis. 47 Heukcha (HCE) is a natural postfermentation green tea extract, which can inhibit high cholesterol diet-induced liver oxidative stress, lipid accumulation and fibrosis, and suppress hypercholesterolemia by increasing the expression of CYP7A1 disease and the occurrence of NAFLD. 48 Ninghong black tea extract could alleviate HFD-induced NAFLD by promoting the expression of peroxisome proliferator-activated receptor α (PPARα) and microsomal triglyceride transfer protein (MTP) in liver tissue, thereby promoting fatty acid β-oxidation and very low-density lipoprotein synthesis.…”

Section: Intervention Of Nafld Through Tea Drinkingmentioning

confidence: 99%

“…Hussain et al investigated the effects of green tea extract (GTE) supplementation in NAFLD patients and showed that a GTE diet could improve metabolic, chemical, inflammatory, and radiological parameters in nondiabetic and dyslipidemic NAFLD patients . Karolczak et al studied whether GTE at a dose of habitual green tea beverages could prevent NAFLD in high-fat diet (HFD) rats, indicating the hepatoprotective potential of GTE in preventing diet-induced hepatic steatosis . Heukcha (HCE) is a natural postfermentation green tea extract, which can inhibit high cholesterol diet-induced liver oxidative stress, lipid accumulation and fibrosis, and suppress hypercholesterolemia by increasing the expression of CYP7A1 disease and the occurrence of NAFLD .…”

Section: Prevention Intervention and Treatment Strategies For Nafldmentioning

confidence: 99%

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

Yang

Huang

et al. 2023

J. Agric. Food Chem.

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Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, is a multifactorial disease resulting from the interaction between environment, genetic background, and metabolic stress. Most treatments for NAFLD include dietary intervention and exercise show limited efficacy due to the complex mechanisms involved in NAFLD. Meanwhile, drug therapy is accompanied by serious side effects. The development of high-efficiency natural supplements is a sustainable strategy for the prevention and treatment of NAFLD. As the second most consumed beverage, tea has health benefits that have been widely recognized. Nevertheless, the intervention of tea active compounds in NAFLD has received limited attention. Tea contains abundant bioactive compounds with potential effects on NAFLD, such as catechins, flavonoids, theanine, tea pigments, and tea polysaccharides. We reviewed the intrinsic and environmental factors and pathogenic mechanisms that affect the occurrence and development of NAFLD, and summarized the influences of exercise, drugs, diet, and tea drinking on NAFLD. On this basis, we further analyzed the potential effects and molecular regulatory mechanisms of tea active compounds on NAFLD and proposed future development directions. This review hopes to provide novel insights into the development and application of tea active compounds in the prevention and treatment of NAFLD.

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Green tea extract prevents the development of nonalcoholic liver steatosis in rats fed a high-fat diet

Cited by 6 publications

References 37 publications

Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

Green tea and selenium-enriched green tea ameliorates non-alcoholic fatty liver disease through peripheral 5-hydroxytryptamine signals in high-fat diet-fed mice

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

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