Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat

Chen, Li Han; Chien, Yi Wen; Liang, Ching-Ping; Chan, Ching-Hung; Fan, Meng-Han; Huang, Hui‐Yu

doi:10.1080/16546628.2017.1347480

Cited by 37 publications

(48 citation statements)

References 71 publications

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“…Plant‐based bioactive compounds from fruits and vegetables have been found to inhibit lipogenesis while promoting brown and beige adipocyte development and thermogenesis and are therefore considered novel nutritional intervention strategies in the prevention of obesity and its related chronic diseases. Mechanisms underlying the anti‐obesogenic activities of some polyphenols, including epigallocatechin gallate, resveratrol, quercetin, and curcumin have been investigated in in vitro, in vivo, and human clinical studies. While anti‐inflammatory and anti‐cancer activities of polyphenols such as GTs and their derivatives (GA and PG) have been examined in breast cancer and colitis models, investigation of these polyphenols in obesity seems to be limited.…”

Section: Discussionmentioning

confidence: 99%

Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High‐Fat Diet‐Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice

Fang

Kim

Yanagisawa

et al. 2019

Molecular Nutrition Food Res

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Scope: Intestinal microbial metabolites from gallotannins (GT), including gallic acid (GA) and pyrogallol (PG), may possess potential anti-obesogenic properties. Lactobacillus plantarum (L. plantarum) found in the intestinal microbiome encodes for enzymatic activities that metabolize GT into GA and PG. Anti-obesogenic activities of orally administered GT in the presence or absence of L. plantarum is examined in gnotobiotic mice fed a high-fat diet (HFD). Methods and results: Germ-free (GF) C57BL/6J mice are divided into three groups, GF control, GF gavaged with GT, and mice colonized with L. plantarum and gavaged with GT. Compared to the control, GT decreases the expressions of lipogenic genes (e.g., fatty acid synthase (FAS)) in epididymal white adipose tissue and increases thermogenic genes (e.g., nuclear factor erythroid-2-like 1 (Nfe2l1)) in interscapular brown adipose tissue. Intestinal colonization with L. plantarum enhances these effects, and mice colonized with L. plantarum exhibit lower levels of tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), leptin and plasma insulin. Conclusions: Results indicate that GT and L. plantarum reduce HFD-induced inflammation, insulin resistance, and promote thermogenesis in adipose tissue potentially through the activity of GT-metabolizing bacterial enzymes yielding absorbable bioactive GT metabolites. These findings imply the potential role of prebiotic-probiotic interactions in the prevention of diet-induced metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High‐Fat Diet‐Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice

Fang

Kim

Yanagisawa

et al. 2019

Molecular Nutrition Food Res

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“…Adipocyte browning has drawn some recent attention to counter adverse metabolic consequences of obesity [28][29][30][31]. Transcriptional factor Zfp423 (C2H2 zinc-finger protein), a white adipocytes identity maintaining gene, is highly expressed in WAT than BAT.…”

Section: Discussionmentioning

confidence: 99%

Ellagic acid promotes browning of white adipose tissues in high-fat diet-induced obesity in rats through suppressing white adipocyte maintaining genes

et al. 2019

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Promoting brown adipose tissue (BAT) formation and function reduces obesity. Ellagic Acid (EA), located abundantly in plant extracts and fruits, has been shown to modulate formation and differentiation of adipocytes, although its role in the process of browning of white adipose tissue (WAT) has not been elucidated. In this study, fifty-six five-week old SD rats were randomly assigned to receive normal diet (ND, 10% lipids) or high-fat diet (HFD, 60% lipid) with or without various dosages of EA for 24 weeks. Our results showed that high fat diet intake triggered overweight, glucose intolerance and white adipocyte hypertrophy, the effects of which were mitigated by EA treatment. Meanwhile, EA supplementation reduced serum resistin levels, improved hepatic steatosis and serum lipid profile in DIO (high fat diet induced obesity) rats. Moreover, EA supplementation significantly decreased mRNA expression of Zfp423 and Aldh1a1, the key determinants of WAT plasticity. EA also increased mRNA expression of brown adipocyte markers including UCP1, PRDM16, Cidea, PGC1α, Ppar-α; beige markers including CD137and TMEM26; mitochondrial biogenesis markers including TFAM in inguinal WAT (iWAT) when compared to their counterparts. EA treatment significantly improved mitochondrial function, as measured by citrate synthase activity. More importantly, EA markedly elevated the expression of UCP1 in iWAT, which is a specific protein of brown adipocyte. In conclusion, our results provided evidence that EA improved obesity-induced dyslipidemia and hepatic steatosis in DIO rats via browning of iWAT through suppressing white adipocyte maintaining genes and promoting expression of key thermogenic genes. These findings suggest that EA could be a promising therapeutic avenue to treat metabolic diseases.

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“…Fish oil intake has been shown to lead to upregulation of UCP1 and the β3 adrenergic receptor in both interscapular BAT and inguinal WAT of mice [31]. In the study of Chen et al (2017), decaffeinated green tea extract supplemented for mice induced expression of variety of browning-related biomarkers, including PPARγ, PRDM-16, BMP-7, FGF-21, UCP-1, CPT-1 CIDEA, and PGC-1α [10].…”

Section: Browning Agentsmentioning

confidence: 99%

Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes

2018

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Mammalian adipose tissue is traditionally categorized into white and brown relating to their function and morphology: while white serves as an energy storage, brown adipose tissue acts as the heat generator maintaining the core body temperature. The most recently identified type of fat, beige adipocyte tissue, resembles brown fat by morphology and function but is developmentally more related to white. The synthesis of beige fat, so-called browning of white fat, has developed into a topical issue in diabetes and metabolism research. This is due to its favorable effect on whole-body energy metabolism and the fact that it can be recruited during adult life. Indeed, brown and beige adipose tissues have been demonstrated to play a role in glucose homeostasis, insulin sensitivity, and lipid metabolism—all factors related to pathogenesis of type 2 diabetes. Many agents capable of initiating browning have been identified so far and tested widely in humans and animal models including in vitro and in vivo experiments. Interestingly, several agents demonstrated to have browning activity are in fact secreted as adipokines from brown and beige fat tissue, suggesting a physiological relevance both in beige adipocyte recruitment processes and in maintenance of metabolic homeostasis. The newest findings on agents driving beige fat recruitment, their mechanisms, and implications on type 2 diabetes are discussed in this review.

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Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat

Cited by 37 publications

References 71 publications

Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High‐Fat Diet‐Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice

Gallotannins and Lactobacillus plantarum WCFS1 Mitigate High‐Fat Diet‐Induced Inflammation and Induce Biomarkers for Thermogenesis in Adipose Tissue in Gnotobiotic Mice

Ellagic acid promotes browning of white adipose tissues in high-fat diet-induced obesity in rats through suppressing white adipocyte maintaining genes

Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes

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