Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA

Park, Dongsun; Jeon, Jeong Hee; Shin, Sunhee; Joo, Seong Soo; Kang, Dae-Hyuck; Moon, Seol-Hee; Jang, Myoung-Uoon; Cho, Yeoung Mi; Kim, Jae Wook; Ji, Hyeong-Jin; Ahn, Byeongwoo; Oh, Ki‐Wan; Kim, Yun-Bae

doi:10.1016/j.reprotox.2008.11.058

Cited by 35 publications

(29 citation statements)

References 26 publications

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“…Accordingly, a CYP2B inhibitor b-ionone was found to significantly suppress cyclophosphamide-induced teratogenesis (Gomes-Carneiro et al, 2003). On the contrary, we demonstrated that green tea extract increased the incidence and severity of fetal defects by up-regulating the expression of CYP2B mRNA in rats (Park et al, 2009).…”

Section: Introductionmentioning

confidence: 68%

“…Control rats were given the same volume of vehicles (water). Four hours after the final administration on GD12, the rats (n 5 10 rats/group except for 5 rats/group sacrificed for CYP analysis) were intraperitoneally challenged with cyclophosphamide (12 mg/kg) (Lee et al, 2005;Shin et al, 2006;Park et al, 2009).…”

Section: Materials and Methods Animals And Treatmentmentioning

confidence: 99%

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Preventive effect of piperonyl butoxide on cyclophosphamide‐induced teratogenesis in rats

Park

Kim

et al. 2009

Birth Defects Research Pt B

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Section: Introductionmentioning

confidence: 68%

Section: Materials and Methods Animals And Treatmentmentioning

confidence: 99%

Preventive effect of piperonyl butoxide on cyclophosphamide‐induced teratogenesis in rats

Park

Kim

et al. 2009

Birth Defects Research Pt B

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“…Additionally, EGCG has been shown to be neuroprotective in aged rats [122] and in animal models of focal and global brain ischemia [91,124,125].…”

Section: Preclinical Studiesmentioning

confidence: 99%

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

et al. 2009

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Tea, the major source of dietary flavonoids, particularly the epicatechins, signifies the second most frequently consumed beverage worldwide, which varies its status from a simple ancient cultural drink to a nutrient component, endowed possible beneficial neuro-pharmacological actions. Accumulating evidence suggests that oxidative stress, resulting in reactive oxygen species generation, plays a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers and metal chelating agents, such as natural tea polyphenols, for therapy. Vast epidemiology data indicate a correlation between occurrence of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, and green tea consumption. In particular, recent literature strengthens the perception that diverse molecular signaling pathways, participating in the neuroprotective activity of the major green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), renders this natural compound as potential agent to reduce the risk of various neurodegenerative diseases. In the current review, we discuss the studies concerning the mechanisms of action implicated in EGCG-induced neuroprotection and discuss the vision to translate these findings into a lifestyle arena.

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“…Based upon CPA's pharmacologic mechanism of action, it is expected that green tea extracts might protect against CPA teratogenesis. Instead, pretreatment with green tea extract by oral gavage between gestation day 6–12 had the opposite effect as demonstrated by the increased incidence and severity of the teratogenic effects of a single dose of CPA administered on gestation day 12 in rats (Park et al, 2009). This was attributed to the simultaneous repression of mRNA for the CPA detoxifying enzyme, CYP3A, and the induction of CYP2B mRNA, which bioactivates CPA.…”

Section: Cyclophosphamide Teratogenicitymentioning

confidence: 99%

PCR‐RFLP to detect codon 248 mutation in exon 7 of p53 tumor suppressor gene

Ouyang¹,

Ge²,

Wu³

et al. 2009

Biochem Molecular Bio Educ

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Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA

Cited by 35 publications

References 26 publications

Preventive effect of piperonyl butoxide on cyclophosphamide‐induced teratogenesis in rats

Preventive effect of piperonyl butoxide on cyclophosphamide‐induced teratogenesis in rats

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

PCR‐RFLP to detect codon 248 mutation in exon 7 of p53 tumor suppressor gene

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