Green tea extract improves high fat diet-induced hypothalamic inflammation, without affecting the serotoninergic system

Okuda, Marcos Hiromu; Zemdegs, Juliane Costa Silva; Santana, Aline Alves de; Santamarina, Aline Boveto; Moreno, Mayara Franzoi; Hachul, Ana Cláudia Losinskas; Santos, Bruno dos; Nascimento, Cláudia Maria Oller do; Ribeiro, Eliane; Oyama, Lila Missae

doi:10.1016/j.jnutbio.2014.05.012

Cited by 32 publications

(21 citation statements)

References 52 publications

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“…However, the CT treatment caused slight weight gain compared with the HFD group, which is in line with a previous study (36). Interestingly, CT treatment did not alter food intake, which agreed with other tea studies (37,38). But the PIO group showed a substantial increase in total food intake or water consumption and in weight gain compared with the HFD group.…”

Section: Discussionsupporting

confidence: 91%

The Flower Tea Coreopsis tinctoria Increases Insulin Sensitivity and Regulates Hepatic Metabolism in Rats Fed a High-Fat Diet

Jiang

Wan

et al. 2015

Endocrinology

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An infusion of Coreopsis tinctoria (CT) flowering tops is traditionally used in Portugal to control hyperglycemia; however, the effects of CT protection against high-fat diet (HFD)-induced hepatic insulin resistance have not been systematically studied and the precise mechanism of action is not clear. The metabolomic profiles of insulin-resistant rats fed a HFD and a CT-supplemented diet (HFD supplemented with CT drinking) for 8 weeks were investigated. Serum samples for clinical biochemistry and liver samples for histopathology and liquid chromatography-mass spectrometry-based metabolomic research were collected. Western blot and quantitative real-time PCR analyses were further used to measure the expression of several relevant enzymes together with perturbed metabolic pathways. Using analysis software, the CT treatment was found to significantly ameliorate the disturbance in 10 metabolic pathways. Combined metabolomic, Western blot, and quantitative real-time PCR analyses revealed that CT treatment significantly improved the glucose homeostasis by, on the one hand, through inhibiting the expression of gluconeogenic pathway key proteins glucose-6-phosphatase and phosphoenolpyruvate carboxykinase and, on the other hand, via regulating the mRNA or protein levels of the Krebs cycle critical enzymes (citrate synthase, succinate dehydrogenase complex, subunit A, flavoprotein, and dihydrolipoamide S-succinyltransferase). These results provide metabolic evidence of the complex pathogenic mechanism involved in hepatic insulin resistance and that the supplementation with CT improves insulin resistance at a global scale. Liquid chromatography-mass spectrometry-based metabolomics approaches are helpful to further understand diabetes-related mechanisms.

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Section: Discussionsupporting

confidence: 91%

The Flower Tea Coreopsis tinctoria Increases Insulin Sensitivity and Regulates Hepatic Metabolism in Rats Fed a High-Fat Diet

Jiang

Wan

et al. 2015

Endocrinology

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“…Similar results were also observed in several recent studies . For example, treatment of male Swiss mice with GTE (50 mg/kg, i.g., daily) for 8 wk decreased body weight and white adipose tissue weight . In another study, EGCG administration (20 mg/kg, i.p., 3 times weekly) to C57BL/6b mice that were fed a high‐fat diet significantly reduced body weight and liver fat accumulation at 42 and 66 wk .…”

Section: Reduction Of Body Weight Alleviation Of Mets and Preventiosupporting

confidence: 91%

“…EGCG treatment also attenuated insulin resistance, plasma cholesterol, and monocyte chemoattractant protein concentrations in mice on the high-fat diet [26,27]. Similar results were also observed in several recent studies [28][29][30]. For example, treatment of male Swiss mice with GTE (50 mg/kg, i.g., daily) for 8 wk decreased body weight and white adipose tissue weight [28].…”

Section: Decrease Of Body Weight and Alleviation Of Mets And Fatty LIsupporting

confidence: 86%

Mechanisms of body weight reduction and metabolic syndrome alleviation by tea

Yang

Zhang

et al. 2015

Molecular Nutrition Food Res

307

299

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Tea, a popular beverage made from leaves of the plant Camellia sinensis, has been shown to reduce body weight, alleviate metabolic syndrome, and prevent diabetes and cardiovascular diseases in animal models and humans. Such beneficial effects have generally been observed in most human studies when the level of tea consumption was 3 to 4 cups (600–900 mg tea catechins) or more per day. Green tea is more effective than black tea. In spite of numerous studies, the fundamental mechanisms for these actions still remain unclear. From a review of the literature, we propose that the two major mechanisms are: 1) decreasing absorption of lipids and proteins by tea constituents in the intestine, thus reducing calorie intake; and 2) activating AMPK by tea polyphenols that are bioavailable in the liver, skeletal muscle, and adipose tissues. The relative importance of these two mechanisms depends on the types of tea and diet consumed by individuals. The activated AMPK would decrease gluconeogenesis and fatty acid synthesis and increase catabolism, leading to body weight reduction and MetS alleviation. Other mechanisms and the health relevance of these beneficial effects of tea consumption remain to be further investigated.

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“…Another study with subjects with metabolic syndrome found that a supplement of green tea extract and infusion for 8 weeks resulted in a reduction in CRP concentration but not in adiponectin, IL-6 or IL-1 (50). Although green tea has been shown to have a positive effect on the reduction of IL-6 expression in the Okuda et al (49) study, there is no consensus about its action on CRP plasma concentration (56).…”

Section: Green Tea and Inflammationmentioning

confidence: 99%

Therapeutic potential of green tea on risk factors for type 2 diabetes in obese adults – a review

et al. 2016

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Green tea has been associated with positive effects in the treatment of obesity and other associated comorbidities such as type 2 diabetes. These benefits are thought to be related to the anti-inflammatory and antioxidant effects of green tea and to the reduction in body fat percentage exhibited by its bioactive compounds. The predominant active compounds in green tea are flavonoid monomers known as catechins, in particular epigallocatechin-3-gallate, which is the most abundant and most effective catechin in metabolic care, particularly among obese patients. The objective of this review was to investigate the effects of green tea on body composition, oxidative stress, inflammation and insulin resistance, risk factors for the development of type 2 diabetes in obese individuals and the mechanisms that underlie the modulatory actions of green tea compounds on these risk factors. Although green tea has therapeutic potential in the treatment of obese individuals, the findings of this review demonstrate the need for a greater number of studies to confirm the positive effects of green tea, especially regarding the modulation of obesity.

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Green tea extract improves high fat diet-induced hypothalamic inflammation, without affecting the serotoninergic system

Cited by 32 publications

References 52 publications

The Flower Tea Coreopsis tinctoria Increases Insulin Sensitivity and Regulates Hepatic Metabolism in Rats Fed a High-Fat Diet

The Flower Tea Coreopsis tinctoria Increases Insulin Sensitivity and Regulates Hepatic Metabolism in Rats Fed a High-Fat Diet

Mechanisms of body weight reduction and metabolic syndrome alleviation by tea

Therapeutic potential of green tea on risk factors for type 2 diabetes in obese adults – a review

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