Green tea extract for mild-to-moderate diabetic peripheral neuropathy A randomized controlled trial

Essmat, Ahmed; Hussein, Mohammed Salah

doi:10.1016/j.ctcp.2021.101317

Cited by 9 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the studies precalculated the needed sample size estimation. Some studies had as few as 25 participants, while the largest number of participants was included in the study by Essmat et al (194 participants) [ 74 ]. The majority of the studies had an average range between 40 and 80 participants (n = 15), that were divided into two or rarely more groups.…”

Section: Resultsmentioning

confidence: 99%

Genetic and Transcriptomic Background of Oxidative Stress and Antioxidative Therapies in Late Complications of Type 2 Diabetes Mellitus: A Systematic Review

Tonin,

Dolžan,

Klen

2024

Antioxidants

View full text Add to dashboard Cite

This systematic review extensively investigated the role of the genetic and transcriptomic factors in late complications of type 2 diabetes mellitus (T2DM) and the current approaches targeting oxidative-stress-related pathways with antioxidant therapies. To cover our broad research area, we have conducted two systematic searches, the first focusing on genetic and transcriptomic factors affecting oxidative stress and the second one focusing on the antioxidant therapies in late complications of T2DM. The final review included 33 genetic and transcriptomic studies and 23 interventional randomized clinical trials. The conducted systematic review highlights the important role of oxidative stress in the development of late complications in T2DM patients. However, the current level of evidence does not support the use of genetic and transcriptomic factors as predictive and prognostic biomarkers for the development of T2DM late complications. Further studies are needed to elucidate the potential of targeting oxidative-stress-related pathways for novel preventative and therapeutic approaches. Additionally, antioxidants both in dietary and supplement form have been shown to improve different metabolic and biochemical parameters in T2DM patients with developed late complications. In recent years, studies have improved in methodological quality despite still mainly focusing on microvascular late complications of T2DM. Furthermore, the observed interventional studies suggest non-homogeneity in the duration of observation. As many studies do not provide post-intervention follow-up testing, it is difficult to assess the long-term health benefits of antioxidant supplementation.

show abstract

Section: Resultsmentioning

confidence: 99%

Genetic and Transcriptomic Background of Oxidative Stress and Antioxidative Therapies in Late Complications of Type 2 Diabetes Mellitus: A Systematic Review

Tonin,

Dolžan,

Klen

2024

Antioxidants

View full text Add to dashboard Cite

show abstract

“…DPN patients had slightly higher physical HRQOL scores than DM foot ulcer patients in previous studies (Sekhar et al, 2015 ). This may be due to the insidious onset of DPN, resulting in some patients with DPN having no obvious self‐reported symptoms (Essmat & Hussein, 2021 ; Yang et al, 2021 ). Therefore, DPN patients rated their physical aspects of HRQOL with higher scores.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with DPN are usually in a state of protective sensory deficit, with abnormal balance, disturbed sleep patterns, increased risk of foot ulcers, and increased disability and mortality (Shiferaw et al, 2020 ). DPN has an insidious onset, and some DPN patients have no obvious symptoms in the early stages (Essmat & Hussein, 2021 ; Yang et al, 2021 ). Therefore, people do not pay enough attention to the disease, which leads to its continuous deterioration with serious consequences (Dogiparthi et al, 2017 ; Miranda & Da Ros, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between health literacy and health‐related quality of life in patients with diabetic peripheral neuropathy: The mediating role of self‐management

Gao

Yan

et al. 2022

Nursing Open

View full text Add to dashboard Cite

Aim The aims of the study were to analyse the current situation of health literacy (HL), self‐management and health‐related quality of life (HRQOL) in patients with diabetic peripheral neuropathy (DPN), to explore the correlation between the three and to verify the mediating role of self‐management in HL and HRQOL. Design A cross‐sectional survey. Methods The convenience sampling method was used to select 401 DPN patients attending the First Hospital of Jinzhou Medical University in Liaoning Province, China, from December 2020 to December 2021 as the study population. The research instrument included socio‐demographic characteristics questionnaire, Health Literacy Management Scale (HeLMS), Summary of Diabetes Self‐Care Activities (SDSCA) and Short‐Form 12‐item Health Survey (SF‐12). SPSS 25.0 was applied to the data for descriptive analysis, Pearson correlation analysis and stratified multiple regression analysis. Mediating effects were tested using SPSS PROCESS macro 4.0 software. Results HL and self‐management of DPN patients correlated positively with HRQOL. The mediation role of self‐management was significant in the relationship between HL and physical and mental HRQOL (physical component summary: β = 0.26, P < 0.01; mental component summary: β = 0.18, P < 0.01), with mediating effects accounting for 35.62% and 34.62% of the total effect. Conclusions There was a positive correlation between HL, self‐management and HRQOL in patients with DPN. Self‐management plays a partially mediating role in the relationship between HL and HRQOL in DPN patients. It means that HRQOL in this population can be improved by increasing HL and thus self‐management in DPN patients. Patient or Public Contribution None.

show abstract

“…Prior research has suggested that tea consumption provides protective bene ts against complications related to diabetes.A randomized controlled trial has established the e cacy of green tea extract (GTE) intake in the treatment of mild to moderate diabetic peripheral neuropathy (DPN) (35).The avonoids present in tea possess potent antioxidant properties and are capable of enhancing apoptotic and neurotrophic factors. They alleviate oxidative stress, thus safeguarding neurons from damage and potentially preventing diabetic retinopathy (75)(76)(77)(78)(79)(80)(81)(82).Research has demonstrated that both pu-erh tea and green tea exert protective effects against diabetic nephropathy.…”

Section: Sensitivity Analysismentioning

confidence: 99%

“…A clinical casecontrol study showed that regular consumption of green tea can lower the risk of diabetic retinopathy by 50% compared to non-consumers (31). Several studies have demonstrated the protective effects of tea intake against diabetic nephropathy (32)(33)(34).A randomized controlled trial has demonstrated the therapeutic value of green tea extract in the treatment of diabetic peripheral neuropathy (35). Animal experimental results suggest that Epigallocatechin-3-O-gallate, a bioactive compound in green tea, has bene cial effects in lowering blood glucose, reducing blood lipids, and exhibiting antioxidative and anti-in ammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Association between tea intake and alcohol consumption and diabetes complications: A two sample Mendelian randomization study

Jia

2024

Preprint

View full text Add to dashboard Cite

Background: Studies have indicated that there is a relationship between tea drinking, alcohol consumption, and a reduced risk of diabetes and its complications. However, there is currently no consensus on the potential relationships between tea drinking, alcohol consumption, and diabetes as well as its complications. In this study, we employed a two-sample Mendelian randomization (MR) analysis for the first time to systematically explore the causal relationships between tea intake, alcohol consumption, and diabetes as well as its complications. Methods: Genetic instruments for tea drinking were identified from a genome-wide association study (GWAS) involving 447,485 individuals. Genetic instruments for alcohol intake were identified from a GWAS involving 462,346 individuals. Summary data for diabetes and its complications were obtained from various GWAS meta-analyses. Causal effects between tea drinking, alcohol consumption, and diabetes as well as its complications were examined. Inverse variance-weighted Mendelian randomization (MR) analysis was conducted as the primary method for causal inference. Further sensitivity analyses were performed to ensure the robustness of the results. Results: The IVW assessment showed a causal relationship between alcohol intake and three diabetic complications. Type 2 diabetes with other specified/multiple/unspecified complications , Type 2 diabetes with ophthalmic complications and Type 2 diabetes with renal complications indicated an association with alcohol intake. However, there was horizontal pleiotropy in the study of alcohol intake and three diabetic complications, making the conclusions unreliable. The IVW assessment showed a causal relationship between tea intake and two diabetic complications. Type 1 diabetes with neurological complications, Type 1 diabetes with peripheral circulatory complications showed an association with tea intake. Conclusion: Our research shows that tea and alcohol consumption have a protective effect against diabetic complications.This research contributes to a deeper understanding of dietary influences on diabetes, offering potential directions for future research and public health advocacy.

show abstract

Green tea extract for mild-to-moderate diabetic peripheral neuropathy A randomized controlled trial

Cited by 9 publications

References 31 publications

Genetic and Transcriptomic Background of Oxidative Stress and Antioxidative Therapies in Late Complications of Type 2 Diabetes Mellitus: A Systematic Review

Genetic and Transcriptomic Background of Oxidative Stress and Antioxidative Therapies in Late Complications of Type 2 Diabetes Mellitus: A Systematic Review

Correlation between health literacy and health‐related quality of life in patients with diabetic peripheral neuropathy: The mediating role of self‐management

Association between tea intake and alcohol consumption and diabetes complications: A two sample Mendelian randomization study

Contact Info

Product

Resources

About