2009
DOI: 10.1080/07315724.2009.10718097
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Green Tea Extract Decreases Oxidative Stress and Improves Insulin Sensitivity in an Animal Model of Insulin Resistance, the Fructose-Fed Rat

Abstract: These data suggest that green tea may be beneficial for people with decreased insulin sensitivity and increased oxidative stress, such as those with the metabolic syndrome or type 2 diabetes.

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Cited by 90 publications
(59 citation statements)
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“…Insulin signaling is impaired under conditions of oxidative stress [28] and polyphenols have been shown to reverse oxidative stress-induced impairments in insulin signaling [29]. Thus our findings suggest that the effects of GSE on decreased plasma glucose are mediated through improved insulin economy, possibly through modulation of cellular redox status improving insulin signaling.…”
Section: Discussionmentioning
confidence: 61%
“…Insulin signaling is impaired under conditions of oxidative stress [28] and polyphenols have been shown to reverse oxidative stress-induced impairments in insulin signaling [29]. Thus our findings suggest that the effects of GSE on decreased plasma glucose are mediated through improved insulin economy, possibly through modulation of cellular redox status improving insulin signaling.…”
Section: Discussionmentioning
confidence: 61%
“…Green tea is well known for those individuals that have increased oxidative stress and decreased insulin sensitivity, such as those with the type II diabetes or metabolic syndrome [17]. The opposite association among various serum markers and consumption of green tea indicates that green tea may perform protectively against disorders of the liver and cardiovascular disease and exert protective effects against oxidative stress and cancer [18].…”
Section: Discussionmentioning
confidence: 99%
“…Administration of polyphenols to diabetic animals resulted in a lower level of markers of oxidative stress as judged by lower levels of products of lipid peroxidation in pancreatic homogenates (Coskun et al 2005), kidneys (Lee, Wang, et al 2009) and blood plasma (Ciocoiu et al 2009;Hininger-Favier et al 2009) of STZ-rats. This may be a result of direct antioxidant activity of polyphenols, as well as a result of their ability to upregulate expression of antioxidant-defense enzymes: glutathione peroxidase (GSHPx) superoxide dismutase and catalase activities (Ciocoiu et al 2009;Lee, Wang, et al 2009;Dixit and Kar 2010).…”
Section: Wwwintechopencommentioning
confidence: 99%