Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder

Suzuki, Takashi; Kumazoe, Motofumi; Kim, Yoonhee; Yamashita, Shigeki; Nakahara, Kiyoshi; Tsukamoto, Shuntaro; Sasaki, Masako; Hagihara, Takatoki; Tsurudome, Yukari; Huang, Yuhui; Maeda‐Yamamoto, Mari; Shinoda, Yuki; Yamaguchi, Wataru; Yamada, Koji; Tachibana, Hirofumi

doi:10.1038/srep02749

Cited by 51 publications

(56 citation statements)

References 38 publications

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“…The HF/HS1GT1Eri diet significantly attenuated the HF/HS diet-induced body weight increase (p,0.01). In contrast, consistent with a previous report (29), the HF/HS1GT (0.2%) group showed no significant difference in body weight compared with the HF/HS group (p.0.05). The same result was obtained in the HF/HS1Eri group.…”

Section: Resultscontrasting

confidence: 53%

“…The doses of both eriodictyol (28) and green tea extract (29) in our study were determined as reference.…”

Section: Methodsmentioning

confidence: 99%

“…Analysis of the green tea extract was measured using HPLC (Supplemental Table 2) as previously described (29). Mouse body weight was assessed once a week.…”

Section: Methodsmentioning

confidence: 99%

“…Extracts of green tea were obtained from green tea leaves using seething water (over 70˚C, approximately 30 min) and freeze-drying techniques as previously described (29). Analysis of the green tea extract was measured using HPLC (Supplemental Table 2) as previously described (29).…”

Section: Methodsmentioning

confidence: 99%

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The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Is Accompanied by Suppression of Cholesterol Synthesis Enzymes

Yamashita

Kumazoe

Nakamura

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Western diets induce obesity associated with an increased risk of hypercholesterolaemia. Indeed, obesity-induced hypercholesterolaemia is correlated with increased coronary cardiovascular disease (CVD) risk. Male C57BL/6J mice were fed a normal diet, highfat and high-sucrose diet (HF/HS), HF/HS with green tea extract powder diet (HF/HS1GT), HF/HS with eriodictyol diet (HF/HS1Eri), or HF/HS with green tea extract powder and eriodictyol diet (HF/HS1GT1Eri) for 8 wk. Body weight was lower in the HF/HS1GT1Eri group than in the HF/HS group (28.3%, p,0.01). The HF/HS diet elicited an upregulation of total cholesterol levels (263%, p,0.001), and low-density lipoprotein (LDL) levels (289%, p,0.001) were significantly suppressed by the GT1Eri diet. Conversely, no change (p.0.05) was observed in the HF/HS1GT and HF/HS1Eri groups. The HF/HS diet-induced hepatic mRNA increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) was ameliorated (273%) by the oral administration of green tea extract and eriodictyol. Moreover, the GT1Eri diet suppressed HF/HS diet-induced upregulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCS) (275%, p,0.05). Furthermore, the LDL receptor (LDLR) levels were higher in the HF/HS1GT1Eri group (150%, p,0.05) than in the HF/ HS group. These results suggest that a combination of green tea and eriodictyol decreases cholesterol levels, particularly LDL levels, accompanied by the suppression of HMGCR and HMGCS levels and upregulation of LDLR levels in the liver.

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Section: Resultscontrasting

confidence: 53%

“…The doses of both eriodictyol (28) and green tea extract (29) in our study were determined as reference.…”

Section: Methodsmentioning

confidence: 99%

“…Analysis of the green tea extract was measured using HPLC (Supplemental Table 2) as previously described (29). Mouse body weight was assessed once a week.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Is Accompanied by Suppression of Cholesterol Synthesis Enzymes

Yamashita

Kumazoe

Nakamura

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…The 3% BLEx group showed inhibited augmentation of HFHSD-induced serum glucose and insulin and a significant difference was observed in the glucose levels of the HFHSD control group and 3% BLEx group. Diets were prepared on the basis of AIN-93G and slightly modified according to previous report (Suzuki et al, 2013).…”

Section: Histology and Liver Lipidsmentioning

confidence: 99%

Blueberry (<i>Vaccinium virgatum</i> Aiton) Leaf Infusion Ameliorates Insulin Resistance in Mice Fed a High-fat, High-sucrose Diet

Yamasaki

Matsuyama

Hayasegawa

et al. 2015

FSTR

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Cardiac Lipid Metabolism Is Modulated by Casimiroa edulis and Crataegus pubescens Aqueous Extracts in High Fat and Fructose (HFF) Diet‐Fed Obese Rats

Pérez‐Ramírez

González-Dávalos

Mora

et al. 2019

Euro J Lipid Sci & Tech

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This study aim to evaluate the effect of Casimiroa edulis and Crataegus pubescens aqueous extracts on cardiac lipotoxicity in obese rats. Both extracts decrease cardiac hypertrophy and steatosis in high fat and fructose (HFF)‐diet‐fed obese rats. C. pubescens decreases the cardiac content of 16 and 18 carbon‐length fatty acids, whereas C. edulis extract does not alter the fatty acid profile. Regarding lipotoxic compounds, C. pubescens reduces the cardiac content of 16 and 18 carbon‐length ceramides and diacylglycerols, whereas C. edulis extract reduces ≥20 carbon‐length lipotoxic compounds. Both extracts down‐regulate fatty acid synthase (Fasn) and acetyl‐CoA carboxylase (Acaca) (lipogenesis), glyceril‐3‐phosphate acyltransferase (Gpat) (diacylglycerol synthesis) and serine palmitoyltransferase 1 (Spt1) (ceramide synthesis), and up‐regulate carnitine palmitoyltransferase 1 (Cpt1) and acyl‐CoA dehydrogenase (Acadm) (β‐oxidation), and the greatest effect is observed with C. pubescens. In addition, C. edulis exerts the greatest cardiac anti‐inflammatory activity, whereas C. pubescens shows the highest cardiac antioxidant activity. The cardioprotective effect of C. pubescens may be associated with its content of (−)‐epigallocatechin gallate, (+)‐catechin, chlorogenic acid, caffeic acid, and β‐campesterol, whereas the beneficial effect of C. edulis may be related to its high content of steroidal saponins and alkaloids. Therefore, these results demonstrate that both herbal aqueous extracts ameliorate cardiac lipotoxicity in HFF‐diet‐fed rats, and C. pubescens exerts a greater beneficial effect. Practical Applications: This study proposes the characterization of fatty acids and lipotoxic compounds (ceramides and diacylglycerols) of cardiac tissue in combination with the determination of the expression of specific genes related to lipid metabolism to identify the mechanisms associated with the cardioprotective effects of herbal extracts. The results obtained in this study demonstrate the cardioprotective potential of Casimiroa edulis and Crataegus pubescens aqueous extracts through the modulation of cardiac lipid metabolism in high fat and fructose diet fed obese rats. Therefore, these herbs can be used for the development of functional beverages or the extraction of bioactive compounds with cardioprotective effect.

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Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder

Cited by 51 publications

References 38 publications

The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Is Accompanied by Suppression of Cholesterol Synthesis Enzymes

The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Is Accompanied by Suppression of Cholesterol Synthesis Enzymes

Blueberry (<i>Vaccinium virgatum</i> Aiton) Leaf Infusion Ameliorates Insulin Resistance in Mice Fed a High-fat, High-sucrose Diet

Cardiac Lipid Metabolism Is Modulated by Casimiroa edulis and Crataegus pubescens Aqueous Extracts in High Fat and Fructose (HFF) Diet‐Fed Obese Rats

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