Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation

Diwan, Bhawna; Sharma, Rohit

doi:10.1007/s10522-022-09976-9

Cited by 10 publications

(4 citation statements)

References 94 publications

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“…In addition, in a study describing the evaluation of chemoprevention of EGCG‐rich green tea infusion against chemically induced liver cancer in rats, it was reported that EGCG‐rich tea‐treated animals had the least incidence of hepatocellular carcinoma (8.33%), followed by common tea treatment (40.00%) and model control rats (87.50%) (Liao et al., 2019). Most recently, a study showed that EGCG‐rich green tea exerted beneficial effects on dextran sulfate sodium (DSS)‐treated ulcerative colitis mice by ameliorating malignant inflammatory stressors and attenuating tumorigenic progression (Diwan & Sharma, 2022). Additionally, the administration of EGCG‐rich green tea extract suppressed the brain amyloid β levels and improved cognitive function in genetically engineered AD mouse models (Kan et al., 2021).…”

Section: Special Tea Products Featuring Tea Polyphenolsmentioning

confidence: 99%

Special tea products featuring functional components: Health benefits and processing strategies

Yang

Meng

Shi

et al. 2023

Comp Rev Food Sci Food Safe

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The functional components in tea confer various potential health benefits to humans. To date, several special tea products featuring functional components (STPFCs) have been successfully developed, such as O‐methylated catechin‐rich tea, γ‐aminobutyric acid‐rich tea, low‐caffeine tea, and selenium‐rich tea products. STPFCs have some unique and enhanced health benefits when compared with conventional tea products, which can meet the specific needs and preferences of different groups and have huge market potential. The processing strategies to improve the health benefits of tea products by regulating the functional component content have been an active area of research in food science. The fresh leaves of some specific tea varieties rich in functional components are used as raw materials, and special processing technologies are employed to prepare STPFCs. Huge progress has been achieved in the research and development of these STPFCs. However, the current status of these STPFCs has not yet been systematically reviewed. Here, studies on STPFCs have been comprehensively reviewed with a focus on their potential health benefits and processing strategies. Additionally, other chemical components with the potential to be developed into special teas and the application of tea functional components in the food industry have been discussed. Finally, suggestions on the promises and challenges for the future study of these STPFCs have been provided. This paper might shed light on the current status of the research and development of these STPFCs. Future studies on STPFCs should focus on screening specific tea varieties, identifying new functional components, evaluating health‐promoting effects, improving flavor quality, and elucidating the interactions between functional components.

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Section: Special Tea Products Featuring Tea Polyphenolsmentioning

confidence: 99%

Special tea products featuring functional components: Health benefits and processing strategies

Yang

Meng

Shi

et al. 2023

Comp Rev Food Sci Food Safe

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“…EGCG is the most abundant polyphenol in green tea extract (GTE) and a strong antioxidant, which is reported to provide numerous health benefits, such as anti-inflammatory, anti-bacterial, and anti-cancerogenic effects [ 10 ]. With respect to IBD, the efficacy of EGCG was shown by using various animal models mimicking UC or CD [ 11 , 12 , 13 , 14 , 15 ]. For instance, EGCG significantly improved disrupted colon architecture and leukocyte infiltration and reduced the level of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) in a dinitrobenzene sulphonic acid (DNBS) rat model.…”

Section: Introductionmentioning

confidence: 99%

“…Analogous effects for EGCG and sulfasalazine were observed, such as a decrease in the disease activity index (DAI) and histological score, as well as the reduction of TNF-α, INF-γ, and the nuclear factor-κBp65 (NF- κBp65) serum levels [ 12 , 13 ]. Recently published studies underline the potential of EGCG for the treatment of IBD in animal studies [ 14 , 15 ]. However, the transfer of the EGCG data to the human condition remains an evident challenge [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Potential of Epigallocatechin-3-gallate (EGCG) as Complementary Medicine for the Treatment of Inflammatory Bowel Disease

Schnur,

Hans,

Dehne

et al. 2023

Pharmaceuticals

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Complementary and alternative medicine has the potential to enrich conventional therapy to improve the treatment of various diseases. Patients that suffer from inflammatory bowel disease, which requires a constant need for medication, have to deal with the adverse effects of repeated application. Natural products such as Epigallocatechin-3-gallate (EGCG) possess the potential to improve symptoms of inflammatory diseases. We investigated the efficacy of EGCG on an inflamed co-culture model simulating IBD and compared it to the efficacies of four commonly applied active pharmaceutical ingredients. EGCG (200 µg/mL) strongly stabilized the TEER value of the inflamed epithelial barrier to 165.7 ± 4.6% after 4 h. Moreover, the full barrier integrity was maintained even after 48 h. This corresponds to the immunosuppressant 6-Mercaptopurin and the biological drug Infliximab. The EGCG treatment significantly decreased the release of the pro-inflammatory cytokines IL-6 (to 0%) and IL-8 (to 14.2%), similar to the effect of the corticosteroid Prednisolone. Therefore, EGCG has a high potential to be deployed as complementary medicine in IBD. In future studies, the improvement of EGCG stability is a key factor in increasing the bioavailability in vivo and fully harnessing the health-improving effects of EGCG.

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“…Amongst the age-associated diseases, inflammatory bowel diseases such as ulcerative colitis (UC) is a major health concern of elderly with minimal therapies available as of today for ageing populations. Diwan and Sharma (2022) present their data which assessed the efficacy of green tea epigallocatechin gallate (EGCG) consumption in preventing the severity and progression of UC using dextran sulphate sodium (DSS)-induced ulcerative colitis model system of 18 months old middle-aged male mice. The study highlights the nurtraceutical value of EGCG and authors recommend that drinking EGCG-rich green tea may be a helpful for reducing the severity of UC during aging.…”

mentioning

confidence: 99%

Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’

Kaur

Sharma

2022

Biogerontology

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Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation

Cited by 10 publications

References 94 publications

Special tea products featuring functional components: Health benefits and processing strategies

Special tea products featuring functional components: Health benefits and processing strategies

The Potential of Epigallocatechin-3-gallate (EGCG) as Complementary Medicine for the Treatment of Inflammatory Bowel Disease

Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’

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